SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mlu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 3mlu HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 2557 FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 8 VAL L 109
ARG L  61
ALA L  19
GLU L  83
 None
 0.93A 1dmiA-3mluL:
undetectable
1dmiB-3mluL:
undetectable		 1dmiA-3mluL:
20.00
1dmiB-3mluL:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3mlu HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 2557 FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 LEU L 136
ALA L 134
LEU L 182
THR L 185
 None
 1.02A 3cfqA-3mluL:
3.8
3cfqB-3mluL:
3.2		 3cfqA-3mluL:
23.15
3cfqB-3mluL:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 3mlu HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 2557 FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 8 ALA L  90
LEU L  28
ASP L  30
TYR L   2
 None
 1.01A 3qj7A-3mluL:
undetectable
3qj7D-3mluL:
undetectable		 3qj7A-3mluL:
22.51
3qj7D-3mluL:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3mlu HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 2557 FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 6 LEU L 136
ALA L 134
LEU L 182
THR L 185
 None
 1.08A 4ikiB-3mluL:
3.2		 4ikiB-3mluL:
22.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 3mlu HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 2557 FAB
LIGHT CHAIN
(Homo
sapiens) 		5 / 7 TYR L  32
SER L  34
TYR L  36
TYR L  49
PRO L  55
 None
 0.68A 5aclA-3mluL:
19.4		 5aclA-3mluL:
50.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3mlu HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 2557 FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 6 LEU L 136
ALA L 134
LEU L 182
THR L 185
 None
 1.06A 5bojA-3mluL:
3.8		 5bojA-3mluL:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3mlu HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 2557 FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 6 LEU L 136
ALA L 134
LEU L 182
THR L 185
 None
 1.01A 5l4iA-3mluL:
2.9		 5l4iA-3mluL:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 3mlu HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 2557 FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 6 LEU L 136
ALA L 134
LEU L 182
THR L 185
 None
 1.03A 5l4iB-3mluL:
2.7		 5l4iB-3mluL:
22.69