SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mlw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5N_A_IPHA903_0 (PROTEIN ARGONAUTE-2)	3mlw	HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1006-15D FAB HEAVY CHAIN (Homo sapiens)	4 / 4	TYR H 59 THR H 57 GLY H 49 LEU H 80	None	1.40A	4w5nA-3mlwH: undetectable	4w5nA-3mlwH: 13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BXN_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	3mlw	HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1006-15D FAB HEAVY CHAIN (Homo sapiens)	5 / 11	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.98A	5bxnH-3mlwH: undetectable 5bxnI-3mlwH: undetectable	5bxnH-3mlwH: 22.49 5bxnI-3mlwH: 21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WQP_A_NCAA302_0 (PROBABLE DEHYDROGENASE)	3mlw	HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1006-15D FAB HEAVY CHAIN (Homo sapiens)	4 / 8	GLN H 39 MET H 89 TYR H 90 MET H 48	None	1.46A	5wqpA-3mlwH: undetectable	5wqpA-3mlwH: 24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BPY_A_ACTA408_0 (THIOREDOXIN REDUCTASE)	3mlw	HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1006-15D FAB HEAVY CHAIN (Homo sapiens)	3 / 3	PRO H 185 SER H 187 SER H 188	None	0.61A	6bpyA-3mlwH: undetectable	6bpyA-3mlwH: 21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3mlw	HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1006-15D FAB HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	1.07A	6drzA-3mlwH: undetectable	6drzA-3mlwH: 16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HWD_H_BO2H301_0 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	3mlw	HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1006-15D FAB HEAVY CHAIN (Homo sapiens)	5 / 12	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	1.07A	6hwdH-3mlwH: undetectable 6hwdI-3mlwH: undetectable	6hwdH-3mlwH: 20.30 6hwdI-3mlwH: 17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HWD_V_BO2V301_0 (PROTEASOME SUBUNIT BETA TYPE-2)	3mlw	HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1006-15D FAB HEAVY CHAIN (Homo sapiens)	5 / 11	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	1.07A	6hwdV-3mlwH: undetectable	6hwdV-3mlwH: 20.30

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4W5N_A_IPHA903_0","PROTEIN ARGONAUTE-2","3mlw","HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1006-15D FAB HEAVY CHAIN","Homo sapiens",4,"TYR H  59;THR H  57;GLY H  49;LEU H  80","None","1.40A","4w5nA-3mlwH:undetectable","4w5nA-3mlwH:13.72"],["5BXN_H_BO2H301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","3mlw","HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1006-15D FAB HEAVY CHAIN","Homo sapiens",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.98A","5bxnH-3mlwH:undetectable;5bxnI-3mlwH:undetectable","5bxnH-3mlwH:22.49;5bxnI-3mlwH:21.69"],["5WQP_A_NCAA302_0","PROBABLE DEHYDROGENASE","3mlw","HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1006-15D FAB HEAVY CHAIN","Homo sapiens",4,"GLN H  39;MET H  89;TYR H  90;MET H  48","None","1.46A","5wqpA-3mlwH:undetectable","5wqpA-3mlwH:24.62"],["6BPY_A_ACTA408_0","THIOREDOXIN REDUCTASE","3mlw","HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1006-15D FAB HEAVY CHAIN","Homo sapiens",3,"PRO H 185;SER H 187;SER H 188","None","0.61A","6bpyA-3mlwH:undetectable","6bpyA-3mlwH:21.37"],["6DRZ_A_H8JA1206_0","5HT2B RECEPTOR, BRIL CHIMERA","3mlw","HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1006-15D FAB HEAVY CHAIN","Homo sapiens",5,"VAL H 207;THR H 205;VAL H 211;GLY H 118;VAL H 152","None","1.07A","6drzA-3mlwH:undetectable","6drzA-3mlwH:16.50"],["6HWD_H_BO2H301_0","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","3mlw","HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1006-15D FAB HEAVY CHAIN","Homo sapiens",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","1.07A","6hwdH-3mlwH:undetectable;6hwdI-3mlwH:undetectable","6hwdH-3mlwH:20.30;6hwdI-3mlwH:17.32"],["6HWD_V_BO2V301_0","PROTEASOME SUBUNIT BETA TYPE-2","3mlw","HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1006-15D FAB HEAVY CHAIN","Homo sapiens",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","1.07A","6hwdV-3mlwH:undetectable","6hwdV-3mlwH:20.30"]]