SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mlx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3mlx HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 3074 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.43A 2y03A-3mlxH:
undetectable		 2y03A-3mlxH:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3mlx HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 3074 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.46A 2y03B-3mlxH:
undetectable		 2y03B-3mlxH:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3mlx HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 3074 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H  62
ILE H  37
ILE H  48
VAL H  67
LEU H  82
 None
 1.02A 3w67B-3mlxH:
undetectable		 3w67B-3mlxH:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 3mlx HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 3074 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 10 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.46A 4ldoA-3mlxH:
undetectable		 4ldoA-3mlxH:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3mlx HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 3074 FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 MET H  69
ASP H  95
PHE H  32
 None
 0.97A 4xeyA-3mlxH:
undetectable		 4xeyA-3mlxH:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3mlx HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 3074 FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 MET H  69
ASP H  95
PHE H  32
 None
 0.91A 4xeyB-3mlxH:
undetectable		 4xeyB-3mlxH:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3mlx HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 3074 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 8 ILE H  51
ARG H  94
LEU H   4
ILE H  29
 None
 0.98A 4xtaB-3mlxH:
undetectable		 4xtaB-3mlxH:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3mlx HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 3074 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ILE H  51
ARG H  94
LEU H   4
ILE H  29
 None
 0.87A 4xumA-3mlxH:
undetectable		 4xumA-3mlxH:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3mlx HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 3074 FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 LEU H  20
ASP H  72
ILE H  29
 None
 0.63A 6dh0B-3mlxH:
undetectable		 6dh0B-3mlxH:
17.21