SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mm5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		4 / 6 LEU B 256
ILE B 207
ARG B 208
VAL B 236
 SF4  B 586 ( 4.9A)
None
None
None
 1.09A 1db1A-3mm5B:
undetectable		 1db1A-3mm5B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		4 / 8 PHE B 332
ILE B 306
LEU B 307
LEU B 320
 None
 0.77A 1eupA-3mm5B:
undetectable		 1eupA-3mm5B:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus;
Archaeoglobus
fulgidus) 		3 / 3 ARG A 113
GLY B  80
ASP B  75
 None
 0.44A 1kf6A-3mm5A:
undetectable
1kf6B-3mm5A:
undetectable		 1kf6A-3mm5A:
21.43
1kf6B-3mm5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus;
Archaeoglobus
fulgidus) 		5 / 10 ARG B  87
ALA B 187
HIS B 186
ALA A 228
GLY A 313
 SRM  B 570 (-3.9A)
None
None
None
None
 1.08A 1mjqG-3mm5B:
undetectable
1mjqH-3mm5B:
undetectable		 1mjqG-3mm5B:
16.00
1mjqH-3mm5B:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		4 / 6 GLY B 136
ILE B 138
GLN B 135
SER B 148
 SF4  B 585 ( 4.9A)
None
SRM  A 580 (-3.5A)
None
 1.02A 1rs7B-3mm5B:
undetectable		 1rs7B-3mm5B:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 104
LEU A 191
LEU A 189
PRO A 172
ILE A 214
 None
 1.25A 1zq9A-3mm5A:
undetectable		 1zq9A-3mm5A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		3 / 3 PHE B 332
VAL B 324
TRP B 323
 None
 0.84A 2cc8A-3mm5B:
undetectable		 2cc8A-3mm5B:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		3 / 3 PHE B 332
VAL B 324
TRP B 323
 None
 0.85A 2ccbA-3mm5B:
undetectable		 2ccbA-3mm5B:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus;
Archaeoglobus
fulgidus) 		5 / 12 ALA A 225
SER A 226
ALA A 233
ALA B 187
PRO B 279
 SRM  B 570 ( 4.0A)
None
None
None
None
 1.20A 2igtC-3mm5A:
undetectable		 2igtC-3mm5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		3 / 3 ASP B 120
TYR B 126
LYS B 316
 None
 0.73A 2othA-3mm5B:
undetectable		 2othA-3mm5B:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 379
THR A 308
VAL A 328
 None
 0.96A 2q64A-3mm5A:
undetectable		 2q64A-3mm5A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		3 / 3 PHE B 332
VAL B 324
TRP B 323
 None
 0.84A 2vx9A-3mm5B:
undetectable		 2vx9A-3mm5B:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		5 / 12 GLU B  91
ARG B  83
PHE A 183
HIS B  33
THR B 118
 SRM  B 570 ( 4.1A)
SRM  B 570 (-2.9A)
SRM  B 570 (-3.2A)
SRM  B 570 (-3.8A)
SRM  B 570 (-4.3A)
 1.46A 2xffA-3mm5B:
undetectable		 2xffA-3mm5B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		4 / 7 SER B 361
TRP A 325
GLU B 274
ASP A 222
 None
 1.24A 3bc9A-3mm5B:
undetectable		 3bc9A-3mm5B:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 343
ALA A 346
ILE A 311
PHE A 373
VAL A 331
 None
 1.10A 3dzuA-3mm5A:
undetectable		 3dzuA-3mm5A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		5 / 10 VAL A 331
ILE A 214
PRO A 172
LEU A 344
ILE A 309
 None
 1.14A 3hbbA-3mm5A:
undetectable		 3hbbA-3mm5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		5 / 9 LEU B 103
VAL B 111
LEU B  62
PHE B  56
VAL B  54
 None
 1.49A 3jwqA-3mm5B:
undetectable		 3jwqA-3mm5B:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		4 / 8 ILE A 340
PHE A 232
ALA A 233
VAL A 333
 None
 0.88A 3me6B-3mm5A:
undetectable		 3me6B-3mm5A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus;
Archaeoglobus
fulgidus) 		5 / 11 GLY A 177
PRO A 178
GLY A 104
ARG B  83
ASP A 187
 SF4  A 575 ( 4.2A)
None
None
SRM  B 570 (-2.9A)
None
 1.41A 3t8nD-3mm5A:
undetectable
3t8nF-3mm5A:
undetectable		 3t8nD-3mm5A:
15.24
3t8nF-3mm5A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		5 / 9 GLY B 269
GLY B 328
ILE B 327
LEU B 338
VAL B 285
 None
 1.02A 3u7sB-3mm5B:
undetectable		 3u7sB-3mm5B:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		5 / 11 ILE A 347
TRP A 348
ARG A 379
ILE A 309
PHE A 212
 None
 1.39A 3vawA-3mm5A:
undetectable		 3vawA-3mm5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		5 / 11 TYR A 199
ILE A 347
TRP A 348
ARG A 379
ILE A 309
 None
 1.45A 3vawA-3mm5A:
undetectable		 3vawA-3mm5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		3 / 3 ARG B 277
LYS B 271
ARG B 276
 None
SRM  B 570 ( 4.1A)
SRM  B 570 (-2.6A)
 1.04A 3w1wA-3mm5B:
undetectable
3w1wB-3mm5B:
undetectable		 3w1wA-3mm5B:
20.80
3w1wB-3mm5B:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		3 / 3 ARG B 276
ARG B 277
LYS B 271
 SRM  B 570 (-2.6A)
None
SRM  B 570 ( 4.1A)
 1.14A 3w1wA-3mm5B:
undetectable
3w1wB-3mm5B:
undetectable		 3w1wA-3mm5B:
20.80
3w1wB-3mm5B:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 231
ARG A 170
LYS A 213
 None
SO3  A 590 (-3.0A)
SO3  A 590 ( 2.6A)
 1.15A 3wipG-3mm5A:
undetectable		 3wipG-3mm5A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		5 / 11 ILE B 145
ASP B 146
ILE B 150
GLY B 149
VAL B 303
 None
 0.84A 4ac9B-3mm5B:
undetectable
4ac9C-3mm5B:
undetectable		 4ac9B-3mm5B:
21.14
4ac9C-3mm5B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		3 / 3 TYR A  73
HIS A 204
ARG A 205
 None
 0.99A 4e7bC-3mm5A:
undetectable		 4e7bC-3mm5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		4 / 8 ASN A 282
CYH A 266
THR A 268
MET A 289
 None
SF4  A 576 (-2.2A)
SF4  A 576 ( 4.4A)
None
 0.82A 4fo4A-3mm5A:
undetectable		 4fo4A-3mm5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		4 / 8 ASN A 282
CYH A 266
THR A 268
MET A 289
 None
SF4  A 576 (-2.2A)
SF4  A 576 ( 4.4A)
None
 0.84A 4fo4B-3mm5A:
undetectable		 4fo4B-3mm5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		5 / 12 SER A 167
TYR A 210
ALA A 315
ASP A 231
GLY A 166
 None
SRM  A 580 (-4.5A)
SRM  A 580 (-3.3A)
None
None
 1.20A 4iilA-3mm5A:
undetectable		 4iilA-3mm5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		4 / 6 GLY B 136
ILE B 138
GLN B 135
SER B 148
 SF4  B 585 ( 4.9A)
None
SRM  A 580 (-3.5A)
None
 1.00A 4kcnA-3mm5B:
undetectable		 4kcnA-3mm5B:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		5 / 12 PRO A 102
GLY A 134
ILE A 137
PHE A 160
LEU A 115
 None
SRM  A 580 (-4.1A)
None
None
None
 1.06A 4kosA-3mm5A:
undetectable		 4kosA-3mm5A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		5 / 12 PRO A 102
GLY A 134
ILE A 137
PHE A 160
LEU A 115
 None
SRM  A 580 (-4.1A)
None
None
None
 1.05A 4kotA-3mm5A:
undetectable		 4kotA-3mm5A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		5 / 12 PRO A 102
GLY A 134
ILE A 137
PHE A 160
LEU A 115
 None
SRM  A 580 (-4.1A)
None
None
None
 1.07A 4kovA-3mm5A:
undetectable		 4kovA-3mm5A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		5 / 12 PRO A 220
GLY A 306
ASP A 240
PHE A 330
GLY A 302
 None
 1.12A 4lxzC-3mm5A:
undetectable		 4lxzC-3mm5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		5 / 12 ASP A 161
THR A 196
GLN A 200
LEU A 203
THR A 171
 None
 1.05A 4ng6A-3mm5A:
undetectable		 4ng6A-3mm5A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		4 / 5 TYR B 355
GLY A 313
ASP A 231
VAL A 376
 None
 1.10A 4nkvD-3mm5B:
undetectable		 4nkvD-3mm5B:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		3 / 3 LYS A 300
ARG B  43
VAL B  44
 None
SRM  B 570 (-2.5A)
None
 0.96A 4x3uA-3mm5A:
undetectable
4x3uB-3mm5A:
undetectable		 4x3uA-3mm5A:
8.61
4x3uB-3mm5A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		5 / 12 VAL B 185
GLY B 194
ALA B 264
ILE B 266
VAL B 303
 None
 1.02A 4xdrA-3mm5B:
undetectable		 4xdrA-3mm5B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		4 / 6 LEU B 103
PHE B  92
ILE B  51
PHE B  93
 None
 1.21A 4y4dA-3mm5B:
undetectable		 4y4dA-3mm5B:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		5 / 12 TYR B 159
ASN B 105
LEU B 103
PHE B  56
ILE B 104
 None
 1.16A 5dv4A-3mm5B:
undetectable		 5dv4A-3mm5B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		4 / 6 SER B 148
HIS B 133
LEU B  61
LEU B  62
 None
 1.23A 5dzke-3mm5B:
undetectable
5dzks-3mm5B:
undetectable		 5dzke-3mm5B:
18.45
5dzks-3mm5B:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		4 / 8 SER B 148
HIS B 133
LEU B  61
LEU B  62
 None
 1.16A 5dzkF-3mm5B:
undetectable
5dzkT-3mm5B:
undetectable		 5dzkF-3mm5B:
18.45
5dzkT-3mm5B:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		3 / 3 PRO B  59
ILE A  99
SER A  16
 None
 0.77A 5fsaA-3mm5B:
undetectable		 5fsaA-3mm5B:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		4 / 6 PHE A 232
PHE B 364
THR A 237
TRP B 366
 None
 1.35A 5g08A-3mm5A:
undetectable		 5g08A-3mm5A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus;
Archaeoglobus
fulgidus) 		4 / 5 GLY A 125
PRO B  59
THR A 127
THR A  24
 None
 1.28A 5h5fA-3mm5A:
undetectable		 5h5fA-3mm5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		4 / 8 TRP A 348
GLU A 202
HIS A 204
THR A 188
 None
 1.42A 5hqaA-3mm5A:
undetectable		 5hqaA-3mm5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		4 / 5 HIS A 290
VAL A 286
GLY A 269
ALA A 270
 None
SF4  A 576 (-4.2A)
None
SF4  A 576 ( 3.7A)
 0.82A 5hwaA-3mm5A:
undetectable		 5hwaA-3mm5A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		3 / 3 ILE B 173
ILE B 306
MET B 155
 None
 0.56A 5i9yA-3mm5B:
2.7		 5i9yA-3mm5B:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		5 / 10 ILE A 309
PHE A 212
TRP A 351
GLY A 312
GLY A 313
 None
 1.43A 5lbtA-3mm5A:
2.4
5lbtB-3mm5A:
2.4		 5lbtA-3mm5A:
18.91
5lbtB-3mm5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		5 / 10 ILE B 145
PRO B 143
ALA B 176
LEU B 175
ILE B 138
 None
SF4  B 585 (-3.8A)
SF4  B 585 ( 4.7A)
None
None
 1.02A 5mvmD-3mm5B:
undetectable
5mvmE-3mm5B:
undetectable		 5mvmD-3mm5B:
10.22
5mvmE-3mm5B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		4 / 5 VAL A  18
HIS B 133
LEU A 126
ASP B 146
 None
 1.37A 5vcvA-3mm5A:
undetectable		 5vcvA-3mm5A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYN_A_HSMA901_0
(EBONY)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		4 / 4 GLU A  10
VAL A  18
LEU A  48
THR A   3
 None
 1.10A 6dynA-3mm5A:
0.0		 6dynA-3mm5A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		4 / 5 GLU A  10
VAL A  18
LEU A  48
THR A   3
 None
 1.07A 6dyoA-3mm5A:
undetectable		 6dyoA-3mm5A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA
(Archaeoglobus
fulgidus) 		4 / 6 LEU A 112
LEU B  62
THR B  58
ASN B  88
 None
 0.90A 6f88B-3mm5A:
undetectable		 6f88B-3mm5A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		4 / 4 LYS A  22
LEU A  48
ALA A  25
LEU A  47
 None
 1.38A 6gnrA-3mm5A:
undetectable		 6gnrA-3mm5A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
(Archaeoglobus
fulgidus) 		4 / 4 LYS A  22
LEU A  48
ALA A  25
LEU A  47
 None
 1.39A 6gnrB-3mm5A:
undetectable		 6gnrB-3mm5A:
12.14