SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mmk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2
(Mus
musculus) 		3 / 3 GLN A 106
ILE A  96
HIS A 283
 None
 0.54A 1fm9A-3mmkA:
undetectable		 1fm9A-3mmkA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2
(Mus
musculus) 		3 / 3 GLN A 106
ILE A  96
HIS A 283
 None
 0.55A 1k74A-3mmkA:
undetectable		 1k74A-3mmkA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2
(Mus
musculus) 		5 / 12 LEU A 275
ALA A 277
ASP A 128
ALA A 105
LEU A 138
 None
 0.90A 2yqzA-3mmkA:
undetectable		 2yqzA-3mmkA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2
(Mus
musculus) 		5 / 12 LEU A 275
ALA A 277
ASP A 128
ALA A 105
LEU A 138
 None
 0.94A 2yqzB-3mmkA:
undetectable		 2yqzB-3mmkA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2
(Mus
musculus) 		4 / 8 LEU A 112
ALA A  91
GLY A 278
PRO A 280
 None
ZN  A 867 ( 4.8A)
None
None
 0.89A 3ny4A-3mmkA:
undetectable		 3ny4A-3mmkA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2
(Mus
musculus) 		4 / 6 ARG A 137
LEU A 132
MET A 133
ASP A 135
 None
 1.00A 4cevA-3mmkA:
undetectable
4cevB-3mmkA:
undetectable		 4cevA-3mmkA:
21.31
4cevB-3mmkA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2
(Mus
musculus) 		4 / 6 MET A 133
ASP A 135
ARG A 137
LEU A 132
 None
 1.00A 4cevA-3mmkA:
undetectable
4cevC-3mmkA:
undetectable		 4cevA-3mmkA:
21.31
4cevC-3mmkA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2
(Mus
musculus) 		4 / 6 ARG A 137
LEU A 132
MET A 133
ASP A 135
 None
 1.00A 4cevD-3mmkA:
undetectable
4cevE-3mmkA:
undetectable		 4cevD-3mmkA:
21.31
4cevE-3mmkA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2
(Mus
musculus) 		4 / 6 ARG A 137
LEU A 132
MET A 133
ASP A 135
 None
 0.98A 4cevE-3mmkA:
undetectable
4cevF-3mmkA:
undetectable		 4cevE-3mmkA:
21.31
4cevF-3mmkA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2
(Mus
musculus) 		4 / 7 ILE A 119
GLY A 271
ALA A 147
GLN A 106
 ZN  A 864 ( 4.8A)
None
None
None
 0.93A 4g0uB-3mmkA:
undetectable		 4g0uB-3mmkA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2
(Mus
musculus) 		3 / 3 GLN A 106
ILE A  96
HIS A 283
 None
 0.70A 5z12B-3mmkA:
undetectable		 5z12B-3mmkA:
18.34