SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mmw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 7 VAL A  79
ILE A  80
GLU A 132
LEU A  12
 None
 0.77A 1j96B-3mmwA:
10.6		 1j96B-3mmwA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 10 GLU A  27
ILE A  34
GLU A  23
ILE A  52
ILE A  18
 None
 1.44A 2j9dD-3mmwA:
undetectable
2j9dE-3mmwA:
undetectable
2j9dF-3mmwA:
undetectable		 2j9dD-3mmwA:
17.36
2j9dE-3mmwA:
17.78
2j9dF-3mmwA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		6 / 12 ASN A 135
GLU A 136
HIS A 196
TYR A 198
GLU A 253
TRP A 286
 CD  A 320 ( 4.9A)
CD  A 320 (-2.5A)
None
None
CD  A 320 (-2.9A)
None
 0.79A 2v3dA-3mmwA:
16.4		 2v3dA-3mmwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 11 ASN A 135
GLU A 136
TYR A 198
GLU A 253
TRP A 286
 CD  A 320 ( 4.9A)
CD  A 320 (-2.5A)
None
CD  A 320 (-2.9A)
None
 0.88A 2v3dB-3mmwA:
15.9		 2v3dB-3mmwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_A_TESA339_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 10 ILE A  94
TRP A 115
ASN A  17
VAL A  50
VAL A  90
 None
 1.11A 3burA-3mmwA:
10.3		 3burA-3mmwA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_B_TESB340_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 10 ILE A  94
TRP A 115
ASN A  17
VAL A  50
VAL A  90
 None
 1.06A 3burB-3mmwA:
11.0		 3burB-3mmwA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 10 ILE A  41
ILE A  42
VAL A  50
GLY A  15
LEU A 307
 None
 1.28A 3elzC-3mmwA:
undetectable		 3elzC-3mmwA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 10 ILE A  41
ILE A  42
VAL A  50
GLY A  15
LEU A 307
 None
 1.30A 3em0A-3mmwA:
undetectable		 3em0A-3mmwA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 TYR A 250
ILE A  80
ILE A  42
ARG A  75
VAL A  76
 None
 1.19A 3fpjB-3mmwA:
undetectable		 3fpjB-3mmwA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 ILE A  11
SER A  48
ILE A  80
VAL A   3
PHE A 130
 None
 1.21A 3vw1D-3mmwA:
undetectable		 3vw1D-3mmwA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 GLU A 188
TRP A 187
LYS A   3
 None
 1.42A 4k7aA-3mmwA:
undetectable		 4k7aA-3mmwA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 7 TYR A 198
GLU A 287
GLU A 253
GLU A  23
 None
None
CD  A 320 (-2.9A)
None
 1.10A 4mi4A-3mmwA:
0.5
4mi4C-3mmwA:
undetectable		 4mi4A-3mmwA:
20.12
4mi4C-3mmwA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 ARG A  14
TRP A 283
ILE A 311
 None
 0.86A 4mwxA-3mmwA:
undetectable		 4mwxA-3mmwA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		4 / 8 GLY A  19
ILE A  18
LEU A  22
GLU A  23
 None
 0.81A 4mwzB-3mmwA:
undetectable		 4mwzB-3mmwA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 GLU A  98
TRP A  30
HIS A  95
 CD  A 318 (-2.3A)
None
None
 1.00A 5xipA-3mmwA:
undetectable		 5xipA-3mmwA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		5 / 12 ILE A 249
THR A 194
THR A 165
GLU A 188
VAL A 184
 None
 1.21A 6bzoC-3mmwA:
undetectable		 6bzoC-3mmwA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3mmw ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 LEU A 114
ASP A 161
ILE A 166
 None
 0.65A 6dh0B-3mmwA:
undetectable		 6dh0B-3mmwA:
13.79