SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mmz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3mmz PUTATIVE HAD FAMILY
HYDROLASE
(Streptomyces
avermitilis) 		4 / 8 ILE A  48
ILE A 151
ILE A 158
ILE A  78
 None
 0.71A 2nniA-3mmzA:
undetectable		 2nniA-3mmzA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 3mmz PUTATIVE HAD FAMILY
HYDROLASE
(Streptomyces
avermitilis) 		4 / 7 GLY A  45
ILE A 151
MET A  58
LEU A  76
 CL  A 503 ( 3.8A)
None
None
None
 0.98A 2xrhA-3mmzA:
undetectable		 2xrhA-3mmzA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 3mmz PUTATIVE HAD FAMILY
HYDROLASE
(Streptomyces
avermitilis) 		3 / 3 ASP A  18
ASN A 110
SER A  62
 CA  A 500 (-2.6A)
CA  A 500 (-2.9A)
None
 0.93A 3lslA-3mmzA:
undetectable
3lslD-3mmzA:
undetectable		 3lslA-3mmzA:
17.37
3lslD-3mmzA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 3mmz PUTATIVE HAD FAMILY
HYDROLASE
(Streptomyces
avermitilis) 		5 / 10 GLY A 146
ILE A 154
VAL A 125
GLY A 109
ILE A 151
 None
 0.91A 3s43B-3mmzA:
undetectable		 3s43B-3mmzA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 3mmz PUTATIVE HAD FAMILY
HYDROLASE
(Streptomyces
avermitilis) 		6 / 12 GLY A 146
ALA A 150
VAL A 125
GLY A 109
ILE A  48
ILE A 151
 None
 1.24A 3s54B-3mmzA:
undetectable		 3s54B-3mmzA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3mmz PUTATIVE HAD FAMILY
HYDROLASE
(Streptomyces
avermitilis) 		6 / 12 GLY A  43
GLU A 153
GLY A 149
ILE A  78
GLY A  47
GLY A  45
 None
None
None
None
None
CL  A 503 ( 3.8A)
 1.27A 5zhmB-3mmzA:
2.1		 5zhmB-3mmzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 3mmz PUTATIVE HAD FAMILY
HYDROLASE
(Streptomyces
avermitilis) 		5 / 7 GLY A  45
GLY A  43
GLY A 149
GLY A 146
GLY A 147
 CL  A 503 ( 3.8A)
None
None
None
None
 0.85A 6ag0A-3mmzA:
undetectable		 6ag0A-3mmzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3mmz PUTATIVE HAD FAMILY
HYDROLASE
(Streptomyces
avermitilis) 		4 / 7 ALA A   5
GLY A   4
LEU A   3
GLY A 122
 None
 0.77A 6nm4A-3mmzA:
undetectable		 6nm4A-3mmzA:
22.33