SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mnf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 3mnf PAC2 FAMILY PROTEIN
(Streptomyces
avermitilis) 		3 / 3 ALA A  29
VAL A 125
TRP A 186
 None
None
CL  A 301 ( 4.9A)
 0.95A 1jo4A-3mnfA:
undetectable		 1jo4A-3mnfA:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 3mnf PAC2 FAMILY PROTEIN
(Streptomyces
avermitilis) 		3 / 3 ALA A  29
VAL A 125
TRP A 186
 None
None
CL  A 301 ( 4.9A)
 0.95A 1jo4B-3mnfA:
undetectable		 1jo4B-3mnfA:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3mnf PAC2 FAMILY PROTEIN
(Streptomyces
avermitilis) 		4 / 7 PHE A  56
ALA A  50
ILE A  98
PRO A  75
 None
 1.04A 1oniA-3mnfA:
undetectable
1oniB-3mnfA:
undetectable		 1oniA-3mnfA:
21.63
1oniB-3mnfA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3mnf PAC2 FAMILY PROTEIN
(Streptomyces
avermitilis) 		4 / 7 ILE A  98
PRO A  75
PHE A  56
ALA A  50
 None
 1.09A 1oniG-3mnfA:
undetectable
1oniI-3mnfA:
undetectable		 1oniG-3mnfA:
21.63
1oniI-3mnfA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3mnf PAC2 FAMILY PROTEIN
(Streptomyces
avermitilis) 		4 / 8 CYH A 108
THR A 165
GLU A  99
VAL A 123
 None
CL  A 301 (-4.7A)
None
None
 1.09A 2fb2A-3mnfA:
undetectable		 2fb2A-3mnfA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 3mnf PAC2 FAMILY PROTEIN
(Streptomyces
avermitilis) 		4 / 5 LEU A 171
GLY A 169
GLU A  99
CYH A 108
 None
CL  A 301 ( 4.1A)
None
None
 1.18A 3aiaA-3mnfA:
undetectable
3aiaB-3mnfA:
undetectable		 3aiaA-3mnfA:
18.53
3aiaB-3mnfA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 3mnf PAC2 FAMILY PROTEIN
(Streptomyces
avermitilis) 		3 / 3 LEU A  36
GLU A 210
ILE A 213
 None
 0.54A 3czhA-3mnfA:
undetectable		 3czhA-3mnfA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 3mnf PAC2 FAMILY PROTEIN
(Streptomyces
avermitilis) 		5 / 9 ARG A 208
LEU A 185
ALA A  32
VAL A  16
LEU A  94
 None
 1.31A 3wsjA-3mnfA:
undetectable		 3wsjA-3mnfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3mnf PAC2 FAMILY PROTEIN
(Streptomyces
avermitilis) 		5 / 12 VAL A  33
ASP A  37
LEU A 122
ALA A  17
ARG A  90
 None
 1.41A 5syfB-3mnfA:
3.7		 5syfB-3mnfA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3mnf PAC2 FAMILY PROTEIN
(Streptomyces
avermitilis) 		5 / 12 ALA A  25
VAL A 231
THR A 202
LEU A 205
ALA A 204
 None
 1.16A 6djzC-3mnfA:
undetectable		 6djzC-3mnfA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3mnf PAC2 FAMILY PROTEIN
(Streptomyces
avermitilis) 		4 / 6 VAL A  84
LEU A  92
LEU A  94
LEU A 209
 None
 0.73A 6f6sA-3mnfA:
undetectable
6f6sB-3mnfA:
undetectable		 6f6sA-3mnfA:
18.50
6f6sB-3mnfA:
14.34