SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mnz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN
(Homo
sapiens;
Mus
musculus;
Homo
sapiens;
Mus
musculus) 		3 / 3 VAL B  34
TRP B  47
TRP A  96
 None
 1.23A 1c4dA-3mnzB:
undetectable
1c4dB-3mnzB:
undetectable		 1c4dA-3mnzB:
4.21
1c4dB-3mnzB:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN
(Homo
sapiens;
Mus
musculus;
Homo
sapiens;
Mus
musculus) 		3 / 4 VAL A  48
TRP B 103
TRP A  35
 None
 1.44A 1gmkC-3mnzA:
undetectable
1gmkD-3mnzA:
undetectable		 1gmkC-3mnzA:
10.38
1gmkD-3mnzA:
10.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 10 ALA A  34
TYR A  36
LEU A  46
TYR A  49
TRP A  96
 None
 0.74A 1jglH-3mnzA:
16.8
1jglL-3mnzA:
26.6		 1jglH-3mnzA:
31.51
1jglL-3mnzA:
59.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN
(Homo
sapiens;
Mus
musculus;
Homo
sapiens;
Mus
musculus) 		4 / 7 THR A 164
VAL B 171
GLY B 169
THR B 192
 None
 0.96A 2a1mA-3mnzA:
undetectable		 2a1mA-3mnzA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 5 LEU A 179
GLY A 128
PRO A 120
VAL A 132
 None
 0.81A 2aojA-3mnzA:
undetectable		 2aojA-3mnzA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 6 LEU B 198
GLY B 199
ALA B 125
PRO B 126
 None
 0.44A 3huoA-3mnzB:
undetectable		 3huoA-3mnzB:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 SER A 127
GLY A 128
THR A 129
 None
 0.17A 3k9wA-3mnzA:
undetectable		 3k9wA-3mnzA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 PHE A  71
TYR A  92
LEU A  47
 None
 0.68A 3keeB-3mnzA:
undetectable		 3keeB-3mnzA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 LYS A 145
SER A 156
GLN A 147
 None
 1.30A 3si7A-3mnzA:
undetectable		 3si7A-3mnzA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 PHE A  71
TYR A  92
LEU A  47
 None
 0.77A 3sueB-3mnzA:
undetectable		 3sueB-3mnzA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN
ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 12 HIS B  35
VAL B  37
TRP B  50
TRP B 103
LEU A  89
 None
 0.65A 3wfhA-3mnzB:
26.1
3wfhB-3mnzB:
19.0		 3wfhA-3mnzB:
56.62
3wfhB-3mnzB:
29.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN
ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 12 HIS B  35
VAL B  37
TRP B 103
TYR A  32
LEU A  89
 None
 0.82A 3wfhA-3mnzB:
26.1
3wfhB-3mnzB:
19.0		 3wfhA-3mnzB:
56.62
3wfhB-3mnzB:
29.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN
ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 12 HIS B  35
VAL B  37
TRP B  50
TRP B 103
LEU A  89
 None
 0.65A 3whxA-3mnzB:
26.2
3whxB-3mnzB:
18.9		 3whxA-3mnzB:
56.31
3whxB-3mnzB:
29.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN
ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 12 HIS B  35
VAL B  37
TRP B 103
TYR A  32
LEU A  89
 None
 0.85A 3whxA-3mnzB:
26.2
3whxB-3mnzB:
18.9		 3whxA-3mnzB:
56.31
3whxB-3mnzB:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 8 GLN A  90
ASN A  93
THR A  94
TRP A  96
 None
 1.18A 4d1yA-3mnzA:
undetectable
4d1yB-3mnzA:
undetectable		 4d1yA-3mnzA:
21.63
4d1yB-3mnzA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 6 ASP A 170
THR A 172
TYR A 140
THR A 109
 None
 1.36A 5b6iB-3mnzA:
undetectable		 5b6iB-3mnzA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 12 GLY B 106
VAL B  34
VAL B   5
LEU B   4
HIS B 102
 None
 1.20A 5kocB-3mnzB:
undetectable		 5kocB-3mnzB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN
(Homo
sapiens;
Mus
musculus;
Homo
sapiens;
Mus
musculus) 		4 / 7 TYR A  32
GLN A  90
TRP B  96
HIS B  35
 None
 1.32A 5ov9B-3mnzA:
undetectable		 5ov9B-3mnzA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 3mnz ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 PRO B 194
SER B 196
SER B 197
 None
 0.49A 6bpyA-3mnzB:
undetectable		 6bpyA-3mnzB:
19.89