SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mop'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3mop MYELOID
DIFFERENTIATION
PRIMARY RESPONSE
PROTEIN MYD88
(Homo
sapiens) 		5 / 12 LEU A  92
GLY A  83
ALA A  84
SER A  85
LEU A  22
 None
 0.97A 1cqeA-3mopA:
undetectable		 1cqeA-3mopA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3mop MYELOID
DIFFERENTIATION
PRIMARY RESPONSE
PROTEIN MYD88
(Homo
sapiens) 		5 / 12 LEU A  92
GLY A  83
ALA A  84
SER A  85
LEU A  22
 None
 0.97A 1cqeB-3mopA:
undetectable		 1cqeB-3mopA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 3mop INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		5 / 9 LEU G  35
ILE G  39
LEU G 100
VAL G  11
LEU G  71
 None
 1.19A 1e7aB-3mopG:
undetectable		 1e7aB-3mopG:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 3mop INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE-LIKE 2
(Homo
sapiens) 		4 / 6 VAL K  75
LEU K  78
PHE K  31
MET K  20
 None
 1.08A 1x8vA-3mopK:
undetectable		 1x8vA-3mopK:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3mop MYELOID
DIFFERENTIATION
PRIMARY RESPONSE
PROTEIN MYD88
(Homo
sapiens) 		4 / 6 ILE A 109
ARG A  88
MET A  19
LEU A  20
 None
 0.93A 2einN-3mopA:
undetectable
2einW-3mopA:
undetectable		 2einN-3mopA:
14.04
2einW-3mopA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3mop MYELOID
DIFFERENTIATION
PRIMARY RESPONSE
PROTEIN MYD88
(Homo
sapiens) 		4 / 7 ILE A 109
ARG A  88
MET A  19
LEU A  20
 None
 0.95A 3ag3A-3mopA:
undetectable
3ag3J-3mopA:
undetectable		 3ag3A-3mopA:
14.04
3ag3J-3mopA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 3mop MYELOID
DIFFERENTIATION
PRIMARY RESPONSE
PROTEIN MYD88
(Homo
sapiens) 		5 / 12 LEU A  75
GLY A  72
LEU A  74
GLN A  67
PHE A  56
 None
 1.05A 3gwwA-3mopA:
undetectable		 3gwwA-3mopA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 3mop INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE-LIKE 2
(Homo
sapiens;
Homo
sapiens) 		4 / 6 GLN K   7
TYR K   6
PHE G  25
LEU G  99
 None
 1.35A 3tgvD-3mopK:
undetectable		 3tgvD-3mopK:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3mop MYELOID
DIFFERENTIATION
PRIMARY RESPONSE
PROTEIN MYD88
(Homo
sapiens) 		4 / 6 ILE A 109
ARG A  88
MET A  19
LEU A  20
 None
 1.01A 3wg7N-3mopA:
undetectable
3wg7W-3mopA:
undetectable		 3wg7N-3mopA:
14.04
3wg7W-3mopA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 3mop INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE-LIKE 2
(Homo
sapiens) 		3 / 3 TYR K   6
GLN K  73
TRP K  63
 None
 1.00A 4kn2C-3mopK:
undetectable		 4kn2C-3mopK:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 3mop INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		4 / 5 VAL G  81
LEU G  14
ILE G   5
LEU G 101
 None
 0.88A 4mghA-3mopG:
undetectable		 4mghA-3mopG:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3mop INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		5 / 10 LEU G 100
ASP G 103
THR G   9
THR G  80
ASP G  86
 None
 1.36A 4n9uA-3mopG:
undetectable		 4n9uA-3mopG:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3mop INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens) 		5 / 12 LEU G 100
ASP G 103
THR G   9
THR G  80
ASP G  86
 None
 1.38A 4ng6A-3mopG:
undetectable		 4ng6A-3mopG:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mop MYELOID
DIFFERENTIATION
PRIMARY RESPONSE
PROTEIN MYD88
(Homo
sapiens) 		5 / 12 LEU A  92
GLY A  83
ALA A  84
SER A  85
LEU A  22
 None
 1.11A 5jvzB-3mopA:
undetectable		 5jvzB-3mopA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3mop MYELOID
DIFFERENTIATION
PRIMARY RESPONSE
PROTEIN MYD88
(Homo
sapiens) 		4 / 7 ILE A 109
ARG A  88
MET A  19
LEU A  20
 None
 0.85A 5xdqN-3mopA:
undetectable
5xdqW-3mopA:
undetectable		 5xdqN-3mopA:
14.04
5xdqW-3mopA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3mop MYELOID
DIFFERENTIATION
PRIMARY RESPONSE
PROTEIN MYD88
(Homo
sapiens) 		4 / 6 ILE A 109
ARG A  88
MET A  19
LEU A  20
 None
 0.98A 5z86N-3mopA:
undetectable
5z86W-3mopA:
undetectable		 5z86N-3mopA:
14.04
5z86W-3mopA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3mop MYELOID
DIFFERENTIATION
PRIMARY RESPONSE
PROTEIN MYD88
(Homo
sapiens) 		4 / 6 ILE A 109
ARG A  88
MET A  19
LEU A  20
 None
 1.01A 5zcoN-3mopA:
undetectable
5zcoW-3mopA:
undetectable		 5zcoN-3mopA:
14.04
5zcoW-3mopA:
22.58