SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mor'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3mor CATHEPSIN B-LIKE
CYSTEINE PROTEASE
(Trypanosoma
brucei) 		6 / 10 GLN A 116
GLY A 120
SER A 121
TRP A 123
HIS A 282
ALA A 283
 None
 0.27A 1stfE-3morA:
26.0
1stfI-3morA:
undetectable		 1stfE-3morA:
22.26
1stfI-3morA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 3mor CATHEPSIN B-LIKE
CYSTEINE PROTEASE
(Trypanosoma
brucei) 		4 / 7 SER A 121
THR A 212
PRO A 213
GLY A 159
 None
None
NAG  A1216 (-4.6A)
None
 0.84A 2ddwB-3morA:
undetectable		 2ddwB-3morA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 3mor CATHEPSIN B-LIKE
CYSTEINE PROTEASE
(Trypanosoma
brucei) 		4 / 6 ASP A 168
SER A  78
LEU A 237
GLY A 329
 None
 0.91A 2j2pA-3morA:
undetectable
2j2pC-3morA:
undetectable		 2j2pA-3morA:
21.23
2j2pC-3morA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 3mor CATHEPSIN B-LIKE
CYSTEINE PROTEASE
(Trypanosoma
brucei) 		4 / 6 ASP A 168
SER A  78
LEU A 237
GLY A 329
 None
 0.89A 2j2pD-3morA:
undetectable
2j2pF-3morA:
undetectable		 2j2pD-3morA:
21.23
2j2pF-3morA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3mor CATHEPSIN B-LIKE
CYSTEINE PROTEASE
(Trypanosoma
brucei) 		3 / 3 SER A 129
ASP A 143
ASP A 182
 GOL  A   3 (-3.3A)
None
GOL  A   3 ( 4.3A)
 0.63A 2plwA-3morA:
undetectable		 2plwA-3morA:
17.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 3mor CATHEPSIN B-LIKE
CYSTEINE PROTEASE
(Trypanosoma
brucei) 		5 / 7 GLN A 116
GLY A 120
HIS A 194
HIS A 282
TRP A 304
 None
 0.35A 3ai8A-3morA:
37.9		 3ai8A-3morA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 3mor CATHEPSIN B-LIKE
CYSTEINE PROTEASE
(Trypanosoma
brucei) 		4 / 6 GLN A 116
GLY A 120
HIS A 194
TRP A 304
 None
 0.27A 3ai8B-3morA:
37.8		 3ai8B-3morA:
39.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3mor CATHEPSIN B-LIKE
CYSTEINE PROTEASE
(Trypanosoma
brucei) 		5 / 12 PHE A  85
GLU A 246
ALA A 331
GLY A 251
ARG A 134
 None
 1.38A 3jzjA-3morA:
undetectable		 3jzjA-3morA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3mor CATHEPSIN B-LIKE
CYSTEINE PROTEASE
(Trypanosoma
brucei) 		4 / 8 GLN A 207
PHE A 208
GLY A 201
ASN A 305
 None
 0.95A 4fgjA-3morA:
undetectable
4fgjB-3morA:
undetectable		 4fgjA-3morA:
20.00
4fgjB-3morA:
20.00