SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mp7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY
(Pyrococcus
furiosus) 		5 / 12 ILE A 290
VAL A  65
GLY A 435
ILE A 436
ILE A 289
 None
 0.82A 1hshA-3mp7A:
undetectable		 1hshA-3mp7A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY
(Pyrococcus
furiosus) 		5 / 9 ILE A 290
VAL A  65
GLY A 435
ILE A 436
ILE A 289
 None
 0.90A 1hshB-3mp7A:
undetectable		 1hshB-3mp7A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY
(Pyrococcus
furiosus) 		5 / 12 ILE A 290
VAL A  65
GLY A 435
ILE A 436
ILE A 289
 None
 0.78A 2rkgA-3mp7A:
undetectable		 2rkgA-3mp7A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY
(Pyrococcus
furiosus) 		5 / 9 ILE A 290
VAL A  65
GLY A 435
ILE A 436
ILE A 289
 None
 0.93A 3s43A-3mp7A:
undetectable		 3s43A-3mp7A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY
(Pyrococcus
furiosus) 		5 / 10 ASN A 286
VAL A  64
THR A 432
GLY A 433
ALA A 421
 None
 1.26A 4fh2A-3mp7A:
undetectable		 4fh2A-3mp7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY
(Pyrococcus
furiosus) 		4 / 8 GLY A 431
THR A 432
THR A 188
ARG A 192
 None
 0.96A 4k87A-3mp7A:
undetectable		 4k87A-3mp7A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY
(Pyrococcus
furiosus) 		4 / 6 ILE A 173
ARG A  29
ILE A 450
GLU A 449
 None
 1.22A 4zzcA-3mp7A:
undetectable
4zzcB-3mp7A:
undetectable		 4zzcA-3mp7A:
22.15
4zzcB-3mp7A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY
(Pyrococcus
furiosus) 		4 / 6 ILE A 173
ARG A  29
ILE A 450
GLU A 449
 None
 1.28A 4zzcB-3mp7A:
undetectable
4zzcC-3mp7A:
undetectable		 4zzcB-3mp7A:
22.15
4zzcC-3mp7A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY
(Pyrococcus
furiosus) 		5 / 12 ILE A 290
VAL A  65
GLY A 435
ILE A 436
ILE A 289
 None
 0.85A 5t8hB-3mp7A:
undetectable		 5t8hB-3mp7A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY
(Pyrococcus
furiosus) 		5 / 12 GLY A 431
ILE A 420
LEU A 437
GLY A 435
GLY A 433
 None
 0.95A 5wyqB-3mp7A:
undetectable		 5wyqB-3mp7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY
(Pyrococcus
furiosus) 		5 / 10 LEU A 354
THR A 355
ILE A 333
PHE A 328
ILE A 299
 None
 1.15A 6ebpC-3mp7A:
undetectable		 6ebpC-3mp7A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY
(Pyrococcus
furiosus) 		5 / 10 GLY A 433
GLY A 431
THR A 434
ASN A 286
ILE A 289
 None
 1.19A 6exiB-3mp7A:
undetectable		 6exiB-3mp7A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY
(Pyrococcus
furiosus) 		5 / 12 GLY A 433
GLY A 431
THR A 434
ASN A 286
ILE A 289
 None
 1.17A 6exiC-3mp7A:
undetectable
6exiD-3mp7A:
undetectable		 6exiC-3mp7A:
12.27
6exiD-3mp7A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY
(Pyrococcus
furiosus) 		5 / 12 GLY A 433
GLY A 431
THR A 434
ASN A 286
ILE A 289
 None
 1.15A 6exiC-3mp7A:
undetectable
6exiD-3mp7A:
undetectable		 6exiC-3mp7A:
12.27
6exiD-3mp7A:
12.27