SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mpi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 12 ARG A  17
GLU A  78
ALA A 257
GLU A  77
ARG A 299
 None
 1.45A 2htqA-3mpiA:
undetectable		 2htqA-3mpiA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		4 / 8 PRO A  57
PRO A 115
VAL A 114
GLU A  59
 None
 1.00A 2v41C-3mpiA:
undetectable
2v41D-3mpiA:
undetectable		 2v41C-3mpiA:
20.79
2v41D-3mpiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		4 / 6 MET A  73
ARG A 246
GLY A  96
MET A  92
 None
GRA  A 402 (-3.4A)
None
FAD  A 400 ( 4.5A)
 1.48A 3aqiA-3mpiA:
undetectable		 3aqiA-3mpiA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		4 / 6 MET A  73
ARG A 246
GLY A  96
MET A  92
 None
GRA  A 402 (-3.4A)
None
FAD  A 400 ( 4.5A)
 1.47A 3aqiB-3mpiA:
undetectable		 3aqiB-3mpiA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 10 TYR A 171
ILE A 128
GLY A 155
PHE A 216
LEU A 169
 None
FAD  A 400 (-3.5A)
None
None
None
 1.18A 3elzB-3mpiA:
undetectable		 3elzB-3mpiA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 12 ASN A  35
PRO A 131
GLY A 213
THR A 158
SER A 210
 None
 1.19A 3iv6A-3mpiA:
undetectable		 3iv6A-3mpiA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 12 PHE A 126
GLY A 125
GLU A 367
ALA A 249
GLY A 368
 FAD  A 400 ( 4.7A)
None
GRA  A 402 (-3.7A)
GRA  A 402 ( 4.8A)
GRA  A 402 (-3.5A)
 1.38A 3jzjA-3mpiA:
undetectable		 3jzjA-3mpiA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		3 / 3 ASN A  91
ASN A 162
GLU A  93
 GRA  A 402 (-3.8A)
None
None
 0.94A 3kpdC-3mpiA:
undetectable		 3kpdC-3mpiA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 12 SER A 207
ASP A 359
ILE A 160
GLY A 125
PHE A 126
 None
None
FAD  A 400 (-4.4A)
None
FAD  A 400 ( 4.7A)
 1.28A 4obwC-3mpiA:
undetectable		 4obwC-3mpiA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 10 ALA A 302
ALA A 305
GLY A 253
GLY A 252
ALA A 251
 None
 1.02A 4qvpK-3mpiA:
undetectable
4qvpL-3mpiA:
undetectable		 4qvpK-3mpiA:
19.29
4qvpL-3mpiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 10 ALA A 302
ALA A 305
GLY A 253
GLY A 252
ALA A 251
 None
 1.01A 4qvpY-3mpiA:
undetectable
4qvpZ-3mpiA:
undetectable		 4qvpY-3mpiA:
19.29
4qvpZ-3mpiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 11 ALA A 302
ALA A 305
GLY A 253
GLY A 252
ALA A 251
 None
 0.99A 4qw1K-3mpiA:
undetectable
4qw1L-3mpiA:
undetectable		 4qw1K-3mpiA:
19.29
4qw1L-3mpiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 10 ALA A 302
ALA A 305
GLY A 253
GLY A 252
ALA A 251
 None
 0.99A 4qw1Y-3mpiA:
undetectable
4qw1Z-3mpiA:
undetectable		 4qw1Y-3mpiA:
19.29
4qw1Z-3mpiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 12 ALA A  80
SER A  84
GLU A  93
PHE A 126
TYR A 363
 None
None
None
FAD  A 400 ( 4.7A)
None
 1.19A 4zj8A-3mpiA:
4.5		 4zj8A-3mpiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		3 / 3 ASP A 233
ARG A 236
TYR A 104
 None
GRA  A 402 ( 4.1A)
None
 1.04A 5a7mA-3mpiA:
undetectable		 5a7mA-3mpiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		3 / 3 ASP A 233
ARG A 236
TYR A 104
 None
GRA  A 402 ( 4.1A)
None
 1.01A 5a7mB-3mpiA:
undetectable		 5a7mB-3mpiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 12 GLY A  64
GLY A 127
GLY A 125
LEU A 117
THR A  54
 None
FAD  A 400 ( 4.4A)
None
None
None
 1.08A 5eqbA-3mpiA:
undetectable		 5eqbA-3mpiA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 12 ALA A 144
ASP A 233
PRO A 231
GLY A 183
SER A 181
 None
None
None
None
GRA  A 402 (-2.6A)
 1.03A 5hfjB-3mpiA:
undetectable		 5hfjB-3mpiA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 12 HIS A 244
LEU A 102
VAL A  55
GLY A  53
SER A 118
 None
 0.98A 5kirA-3mpiA:
undetectable		 5kirA-3mpiA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		3 / 3 ASN A 336
TYR A 357
CYH A 260
 None
 1.06A 5lsuB-3mpiA:
undetectable		 5lsuB-3mpiA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 10 ILE A  56
GLY A  53
GLY A  50
LEU A 117
ALA A  98
 None
 1.00A 5o96C-3mpiA:
undetectable
5o96D-3mpiA:
undetectable		 5o96C-3mpiA:
19.34
5o96D-3mpiA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		4 / 8 ALA A 289
ILE A 265
ALA A 264
LEU A 261
 None
 0.81A 5te8B-3mpiA:
undetectable		 5te8B-3mpiA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 10 ALA A 166
LEU A 169
VAL A 168
LEU A 215
ILE A 197
 None
 1.12A 5v02B-3mpiA:
1.5
5v02R-3mpiA:
undetectable		 5v02B-3mpiA:
14.36
5v02R-3mpiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		4 / 8 GLY A 253
LEU A 256
CYH A 334
SER A 332
 None
 0.95A 5xu8A-3mpiA:
undetectable		 5xu8A-3mpiA:
20.68