SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mpp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 8 ASN G1007
GLU G1293
GLY G1294
PHE G1061
 None
 0.75A 1ykiA-3mppG:
undetectable
1ykiB-3mppG:
undetectable		 1ykiA-3mppG:
17.81
1ykiB-3mppG:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 8 PHE G1061
ASN G1007
GLU G1293
GLY G1294
 None
 0.77A 1ykiA-3mppG:
undetectable
1ykiB-3mppG:
undetectable		 1ykiA-3mppG:
17.81
1ykiB-3mppG:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 8 ASN G1007
GLU G1293
GLY G1294
PHE G1061
 None
 0.77A 1ykiC-3mppG:
undetectable
1ykiD-3mppG:
undetectable		 1ykiC-3mppG:
17.81
1ykiD-3mppG:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 8 PHE G1061
ASN G1007
GLU G1293
GLY G1294
 None
 0.78A 1ykiC-3mppG:
undetectable
1ykiD-3mppG:
undetectable		 1ykiC-3mppG:
17.81
1ykiD-3mppG:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		3 / 3 GLY G1097
ARG G 940
TYR G1227
 None
 0.81A 2opxA-3mppG:
undetectable		 2opxA-3mppG:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 6 ASP G1172
TYR G1173
TYR G1175
LEU G1176
 None
 1.14A 2w98A-3mppG:
undetectable
2w98B-3mppG:
undetectable		 2w98A-3mppG:
21.29
2w98B-3mppG:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 8 LYS G 943
TYR G1142
ASN G1134
PRO G1131
 None
 1.49A 3bjwD-3mppG:
undetectable		 3bjwD-3mppG:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		3 / 3 GLY G 885
ASP G 882
SER G 872
 None
 0.64A 3brfA-3mppG:
7.1		 3brfA-3mppG:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		3 / 3 TYR G1107
ASP G1179
ASP G1183
 None
 0.85A 3ou6B-3mppG:
undetectable		 3ou6B-3mppG:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 7 TYR G1146
LEU G1145
ASN G1007
TYR G 944
 None
 1.22A 4f8yC-3mppG:
undetectable
4f8yD-3mppG:
undetectable		 4f8yC-3mppG:
16.97
4f8yD-3mppG:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 8 ASN G1001
ARG G1132
ASN G1141
ILE G1140
 None
 0.82A 4k0bA-3mppG:
undetectable		 4k0bA-3mppG:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 8 ASN G1001
ARG G1132
ASN G1141
ILE G1140
 None
 0.84A 4l7iA-3mppG:
undetectable		 4l7iA-3mppG:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		5 / 12 ALA G 869
SER G 883
ILE G1069
GLY G1071
ASN G 936
 None
 1.09A 4obwA-3mppG:
undetectable		 4obwA-3mppG:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 5 ILE G 978
LYS G1065
ILE G1064
VAL G1062
 None
 0.99A 5jmnA-3mppG:
undetectable		 5jmnA-3mppG:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		5 / 10 TYR G 996
ILE G 973
ILE G 979
ILE G1012
ILE G1014
 None
 1.05A 5murE-3mppG:
undetectable		 5murE-3mppG:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		5 / 10 TYR G 996
ILE G 979
ILE G1024
ILE G1012
ILE G1014
 None
 0.91A 5murE-3mppG:
undetectable		 5murE-3mppG:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		4 / 8 PRO G 942
GLU G1293
TRP G1096
TYR G1146
 None
 1.36A 5oh1C-3mppG:
undetectable		 5oh1C-3mppG:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		3 / 3 LEU G1270
GLN G1267
LYS G1219
 None
 0.90A 6exiB-3mppG:
undetectable		 6exiB-3mppG:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3mpp BOTULINUM NEUROTOXIN
TYPE G
(Clostridium
botulinum) 		3 / 3 LEU G1270
GLN G1267
LYS G1219
 None
 0.96A 6exiA-3mppG:
undetectable		 6exiA-3mppG:
10.57