SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mpx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 11 PHE A1021
LEU A1037
LEU A1108
LEU A 914
LEU A1036
 None
 1.26A 1mx1B-3mpxA:
undetectable		 1mx1B-3mpxA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 9 TYR A1046
LEU A 967
LEU A 963
ARG A1042
ALA A 906
 None
 1.23A 2bxcB-3mpxA:
undetectable		 2bxcB-3mpxA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 5 LEU A1003
GLN A 944
LEU A 942
GLU A 941
 None
 1.10A 3h5gA-3mpxA:
undetectable
3h5gB-3mpxA:
undetectable		 3h5gA-3mpxA:
6.67
3h5gB-3mpxA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 ILE A 959
GLU A 904
TYR A1046
LEU A1043
 None
 0.98A 3rqwI-3mpxA:
undetectable
3rqwJ-3mpxA:
undetectable		 3rqwI-3mpxA:
21.36
3rqwJ-3mpxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 5 ARG A1166
LEU A1176
PRO A1173
ASP A1196
 None
 1.14A 3ufnA-3mpxA:
undetectable
3ufnB-3mpxA:
undetectable		 3ufnA-3mpxA:
10.30
3ufnB-3mpxA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 4 HIS A1096
GLU A1117
HIS A1132
LEU A1153
 None
 1.33A 4m2rA-3mpxA:
undetectable		 4m2rA-3mpxA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 7 LEU A1004
LEU A 942
ARG A 943
LEU A 946
 None
 0.76A 4wg0B-3mpxA:
undetectable
4wg0C-3mpxA:
undetectable		 4wg0B-3mpxA:
2.53
4wg0C-3mpxA:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 7 LEU A 942
ARG A 943
LEU A 946
LEU A1004
 None
 0.67A 4wg0L-3mpxA:
undetectable
4wg0M-3mpxA:
undetectable		 4wg0L-3mpxA:
2.53
4wg0M-3mpxA:
2.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 9 ALA A 925
LEU A1003
LEU A1014
LEU A 942
ARG A 939
 None
 1.47A 4x30A-3mpxA:
undetectable		 4x30A-3mpxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 TYR A1000
LEU A 926
LEU A1014
GLY A 920
MET A 923
 None
 1.19A 4zp0A-3mpxA:
3.9		 4zp0A-3mpxA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 TYR A 907
LEU A 914
LEU A 949
PHE A 997
LEU A1001
 UNX  A   7 ( 4.9A)
None
None
None
None
 1.11A 5iepA-3mpxA:
undetectable		 5iepA-3mpxA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 7 PHE A1044
ARG A1042
LEU A1043
ALA A1081
 None
 1.29A 6b89A-3mpxA:
undetectable		 6b89A-3mpxA:
14.01