SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mq3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 9 ILE A 176
LEU A 324
GLY A 200
CYH A  80
ALA A 197
 None
 1.00A 1e7bA-3mq3A:
undetectable		 1e7bA-3mq3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		4 / 6 GLN A 338
ASP A 339
VAL A 211
HIS A 333
 None
 1.42A 1ekjG-3mq3A:
undetectable
1ekjH-3mq3A:
undetectable		 1ekjG-3mq3A:
21.11
1ekjH-3mq3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		4 / 7 SER A 240
ALA A 216
SER A 221
ALA A 223
 None
 0.96A 1k5qA-3mq3A:
0.0
1k5qB-3mq3A:
undetectable		 1k5qA-3mq3A:
18.55
1k5qB-3mq3A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 10 LEU A  88
LEU A 141
ALA A  93
SER A  95
LEU A  96
 None
 1.09A 1pxxA-3mq3A:
0.5		 1pxxA-3mq3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 12 PHE A  72
LEU A 165
ALA A 164
SER A  95
ALA A  93
 None
 1.09A 2bxpA-3mq3A:
undetectable		 2bxpA-3mq3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		4 / 7 SER A  36
LEU A  69
HIS A 122
THR A  60
 None
 1.07A 2f78A-3mq3A:
undetectable		 2f78A-3mq3A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		4 / 7 SER A  36
LEU A  69
HIS A 122
THR A  60
 None
 1.15A 2f78B-3mq3A:
undetectable		 2f78B-3mq3A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 9 CYH A  61
THR A  64
PHE A 454
VAL A 215
LEU A 213
 None
 1.40A 2zb8A-3mq3A:
0.0		 2zb8A-3mq3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 12 ALA A 245
ALA A 326
PHE A 279
GLY A 219
THR A 218
 None
 1.17A 2zifB-3mq3A:
undetectable		 2zifB-3mq3A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 12 VAL A 285
LEU A 136
GLU A 179
ARG A  87
ALA A  79
 None
 1.42A 3apvA-3mq3A:
undetectable		 3apvA-3mq3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 12 VAL A 285
LEU A 136
GLU A 179
ARG A  87
ALA A  79
 None
 1.36A 3apvB-3mq3A:
undetectable		 3apvB-3mq3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 12 ILE A 449
ILE A 412
LEU A 411
GLY A 348
VAL A 416
 None
 1.06A 3rukB-3mq3A:
undetectable		 3rukB-3mq3A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 10 ALA A 203
GLY A  70
LEU A 165
LEU A  88
ILE A  92
 None
 1.15A 3wdmB-3mq3A:
undetectable		 3wdmB-3mq3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 9 ALA A 203
GLY A  70
LEU A 165
LEU A  88
ILE A  92
 None
 1.13A 3wdmC-3mq3A:
undetectable		 3wdmC-3mq3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 10 ALA A 203
GLY A  70
LEU A 165
LEU A  88
ILE A  92
 None
 0.98A 3wdmD-3mq3A:
undetectable		 3wdmD-3mq3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 12 LEU A 141
TYR A 144
ALA A  93
SER A  95
LEU A  96
 None
 1.14A 4coxA-3mq3A:
undetectable		 4coxA-3mq3A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 12 LEU A 141
TYR A 144
ALA A  93
SER A  95
LEU A  96
 None
 1.12A 4coxB-3mq3A:
0.9		 4coxB-3mq3A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 12 LEU A 141
TYR A 144
ALA A  93
SER A  95
LEU A  96
 None
 1.13A 4coxD-3mq3A:
undetectable		 4coxD-3mq3A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		3 / 3 ASP A 242
VAL A 251
ASN A 217
 None
 0.81A 4lmnA-3mq3A:
undetectable		 4lmnA-3mq3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 12 LEU A  88
LEU A 141
ALA A  93
SER A  95
LEU A  96
 None
 1.02A 4rrxA-3mq3A:
undetectable		 4rrxA-3mq3A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 12 LEU A  88
LEU A 141
ALA A  93
SER A  95
LEU A  96
 None
 1.02A 4rrxB-3mq3A:
undetectable		 4rrxB-3mq3A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 12 GLY A 200
GLY A  77
ALA A  76
ILE A  52
ASN A  49
 None
 0.96A 4rtmA-3mq3A:
undetectable		 4rtmA-3mq3A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		5 / 10 PHE A  41
GLY A  66
LEU A 213
ALA A 206
ALA A  58
 None
 0.98A 4wnuD-3mq3A:
undetectable		 4wnuD-3mq3A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		3 / 3 LEU A 189
TYR A 137
SER A 130
 None
 0.88A 5iktA-3mq3A:
undetectable		 5iktA-3mq3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		4 / 5 TYR A  23
SER A  57
ALA A  58
GLN A 120
 None
 1.16A 5n0wB-3mq3A:
undetectable		 5n0wB-3mq3A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1
(Bos
taurus) 		4 / 5 TYR A  23
SER A  57
ALA A  58
GLN A 120
 None
 1.21A 5n4iA-3mq3A:
undetectable		 5n4iA-3mq3A:
25.75