SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mq4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		5 / 12 ILE A 154
SER A  42
ILE A  43
ASN A 361
LEU A  83
 None
 1.03A 1dlsA-3mq4A:
undetectable		 1dlsA-3mq4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		3 / 3 ALA A 365
VAL A 362
TRP A 363
 None
 1.03A 1gmkA-3mq4A:
undetectable
1gmkB-3mq4A:
undetectable		 1gmkA-3mq4A:
3.87
1gmkB-3mq4A:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		5 / 12 ASN A 167
LEU A 169
ALA A 166
GLN A 176
LEU A  54
 None
 1.16A 2aa5A-3mq4A:
undetectable		 2aa5A-3mq4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		5 / 12 ASN A 167
LEU A 169
ALA A 166
GLN A 176
LEU A  54
 None
 1.15A 2aa5B-3mq4A:
undetectable		 2aa5B-3mq4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		5 / 12 LEU A 169
ALA A 166
GLN A 176
SER A 162
LEU A  54
 None
 1.37A 2aa5B-3mq4A:
undetectable		 2aa5B-3mq4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		5 / 12 ASN A 167
LEU A 169
ALA A 166
GLN A 176
LEU A  54
 None
 1.19A 2aa6A-3mq4A:
undetectable		 2aa6A-3mq4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		5 / 12 ASN A 167
LEU A 169
ALA A 166
GLN A 176
LEU A  54
 None
 1.18A 2aa6B-3mq4A:
undetectable		 2aa6B-3mq4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		4 / 8 GLY A  75
HIS A  77
ILE A  43
ASN A 361
 None
 0.94A 2x0pA-3mq4A:
undetectable		 2x0pA-3mq4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		3 / 3 TRP A 363
ALA A 365
VAL A 362
 None
 1.01A 3l8lA-3mq4A:
undetectable
3l8lB-3mq4A:
undetectable		 3l8lA-3mq4A:
3.87
3l8lB-3mq4A:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		5 / 12 ALA A 282
LEU A 216
GLY A 332
ALA A 333
TYR A 492
 None
 1.17A 4pclA-3mq4A:
2.8		 4pclA-3mq4A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PL1_A_SAMA401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		5 / 11 PHE A 195
PRO A  56
SER A 181
ILE A 163
ASN A 167
 None
None
Z99  A 514 (-4.6A)
None
None
 1.32A 4pl1A-3mq4A:
2.0		 4pl1A-3mq4A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		5 / 11 TYR A 349
VAL A 408
ILE A 412
ILE A  89
ILE A  43
 None
 1.05A 5hw8A-3mq4A:
undetectable
5hw8D-3mq4A:
undetectable		 5hw8A-3mq4A:
14.84
5hw8D-3mq4A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		5 / 12 LEU A  51
LEU A 449
GLY A 445
ILE A 452
ALA A 421
 None
 1.29A 5j7wC-3mq4A:
undetectable		 5j7wC-3mq4A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		5 / 9 ALA A 115
ASP A 112
GLY A 155
ILE A 154
VAL A  57
 None
 1.12A 5kr0A-3mq4A:
undetectable		 5kr0A-3mq4A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		4 / 7 ALA A 282
ASP A 211
ILE A 212
ILE A 336
 None
 0.98A 6fbnA-3mq4A:
undetectable		 6fbnA-3mq4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		5 / 12 LEU A  51
LEU A 449
GLY A 445
ILE A 452
ALA A 421
 None
 1.34A 6qyaB-3mq4A:
undetectable		 6qyaB-3mq4A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		5 / 12 LEU A  51
LEU A 449
GLY A 445
ILE A 452
ALA A 421
 None
 1.34A 6qyaD-3mq4A:
undetectable		 6qyaD-3mq4A:
22.88