SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		4 / 8 TYR A 183
TYR A 165
LEU A 181
SER A 179
 None
 0.94A 1i7zA-3mr1A:
undetectable		 1i7zA-3mr1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		5 / 12 HIS A  77
THR A 166
HIS A 168
GLU A 201
TYR A  60
 PO4  A 252 (-4.2A)
None
MN  A 249 ( 3.4A)
MN  A 249 ( 2.7A)
None
 1.27A 1j36A-3mr1A:
undetectable		 1j36A-3mr1A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		5 / 12 HIS A  77
THR A 166
HIS A 168
GLU A 201
TYR A  60
 PO4  A 252 (-4.2A)
None
MN  A 249 ( 3.4A)
MN  A 249 ( 2.7A)
None
 1.27A 1j36B-3mr1A:
undetectable		 1j36B-3mr1A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		5 / 11 PRO A 178
LEU A 143
VAL A 137
GLY A 133
LEU A 181
 None
 1.30A 1lwcA-3mr1A:
undetectable		 1lwcA-3mr1A:
19.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		4 / 7 CYH A  68
HIS A  77
HIS A 175
TRP A 219
 None
PO4  A 252 (-4.2A)
PO4  A 252 (-3.7A)
None
 0.82A 1yvmA-3mr1A:
40.7		 1yvmA-3mr1A:
52.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		4 / 7 TYR A  60
CYH A  68
HIS A  77
HIS A 175
 None
None
PO4  A 252 (-4.2A)
PO4  A 252 (-3.7A)
 0.36A 1yvmA-3mr1A:
40.7		 1yvmA-3mr1A:
52.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		4 / 5 THR A  28
THR A 106
HIS A 234
LEU A 248
 None
 1.16A 2zj0A-3mr1A:
undetectable		 2zj0A-3mr1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		4 / 5 THR A  28
THR A 106
HIS A 234
LEU A 248
 None
 1.19A 3ce6A-3mr1A:
undetectable		 3ce6A-3mr1A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		4 / 5 THR A  28
THR A 106
HIS A 234
LEU A 248
 None
 1.17A 3ce6C-3mr1A:
undetectable		 3ce6C-3mr1A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		4 / 8 ARG A 163
VAL A 161
TYR A 148
ILE A 150
 None
 1.01A 3remA-3mr1A:
undetectable		 3remA-3mr1A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		4 / 8 ARG A 163
VAL A 161
TYR A 148
ILE A 150
 None
 1.03A 3remB-3mr1A:
undetectable		 3remB-3mr1A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		4 / 5 THR A  28
THR A 106
HIS A 234
LEU A 248
 None
 1.30A 4lvcA-3mr1A:
undetectable		 4lvcA-3mr1A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		4 / 5 THR A  28
THR A 106
HIS A 234
LEU A 248
 None
 1.29A 4lvcC-3mr1A:
undetectable		 4lvcC-3mr1A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		3 / 3 MET A 203
HIS A  77
GLY A 167
 None
PO4  A 252 (-4.2A)
None
 0.86A 5gwzB-3mr1A:
undetectable		 5gwzB-3mr1A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		4 / 7 GLY A 167
HIS A 168
ASP A 105
HIS A  77
 None
MN  A 249 ( 3.4A)
MN  A 250 (-2.5A)
PO4  A 252 (-4.2A)
 0.69A 5nnwD-3mr1A:
undetectable		 5nnwD-3mr1A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		4 / 7 GLY A 167
HIS A 168
ASP A 105
HIS A  77
 None
MN  A 249 ( 3.4A)
MN  A 250 (-2.5A)
PO4  A 252 (-4.2A)
 0.71A 5no9D-3mr1A:
undetectable		 5no9D-3mr1A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		3 / 3 PHE A 197
ASP A 176
LYS A   3
 None
 0.83A 6awtD-3mr1A:
undetectable		 6awtD-3mr1A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		5 / 12 VAL A 161
LEU A 192
VAL A 137
THR A 199
GLY A 167
 None
None
None
MN  A 249 ( 3.7A)
None
 1.24A 6brdA-3mr1A:
undetectable		 6brdA-3mr1A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		4 / 5 THR A  28
THR A 106
HIS A 234
LEU A 248
 None
 1.31A 6gbnA-3mr1A:
undetectable		 6gbnA-3mr1A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 3mr1 METHIONINE
AMINOPEPTIDASE
(Rickettsia
prowazekii) 		4 / 5 THR A  28
THR A 106
HIS A 234
LEU A 248
 None
 1.31A 6gbnD-3mr1A:
undetectable		 6gbnD-3mr1A:
22.12