SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mr7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3mr7 ADENYLATE/GUANYLATE
CYCLASE/HYDROLASE,
ALPHA/BETA FOLD
FAMILY
(Ruegeria
pomeroyi) 		5 / 11 ALA A  66
ALA A  67
LEU A   8
ALA A  45
ILE A 102
 None
 1.04A 2aclE-3mr7A:
undetectable		 2aclE-3mr7A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 3mr7 ADENYLATE/GUANYLATE
CYCLASE/HYDROLASE,
ALPHA/BETA FOLD
FAMILY
(Ruegeria
pomeroyi) 		4 / 7 ILE A 134
SER A 132
ARG A 119
ILE A 158
 None
 0.90A 2q6hA-3mr7A:
undetectable		 2q6hA-3mr7A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3mr7 ADENYLATE/GUANYLATE
CYCLASE/HYDROLASE,
ALPHA/BETA FOLD
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 ALA A  66
ALA A  67
LEU A   8
ALA A  45
ILE A 102
 None
 0.95A 3h0aA-3mr7A:
undetectable		 3h0aA-3mr7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3mr7 ADENYLATE/GUANYLATE
CYCLASE/HYDROLASE,
ALPHA/BETA FOLD
FAMILY
(Ruegeria
pomeroyi) 		5 / 9 LEU A 120
VAL A 135
ILE A   7
ALA A   6
ALA A  71
 None
 1.29A 3mdtA-3mr7A:
undetectable		 3mdtA-3mr7A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 3mr7 ADENYLATE/GUANYLATE
CYCLASE/HYDROLASE,
ALPHA/BETA FOLD
FAMILY
(Ruegeria
pomeroyi) 		5 / 9 ILE A  42
ARG A  94
LEU A 120
GLU A 121
GLY A 127
 None
 1.41A 3nxuB-3mr7A:
undetectable		 3nxuB-3mr7A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3mr7 ADENYLATE/GUANYLATE
CYCLASE/HYDROLASE,
ALPHA/BETA FOLD
FAMILY
(Ruegeria
pomeroyi) 		4 / 4 LEU A   8
ARG A  34
ILE A  42
ILE A  49
 None
 1.33A 5dzk2-3mr7A:
undetectable
5dzkM-3mr7A:
undetectable
5dzkN-3mr7A:
undetectable		 5dzk2-3mr7A:
2.82
5dzkM-3mr7A:
23.29
5dzkN-3mr7A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3mr7 ADENYLATE/GUANYLATE
CYCLASE/HYDROLASE,
ALPHA/BETA FOLD
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 ALA A  66
ALA A  67
LEU A   8
ALA A  45
ILE A 102
 None
 1.02A 6a60D-3mr7A:
undetectable		 6a60D-3mr7A:
17.89