SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		4 / 7 PHE A  19
ALA A 132
ILE A  40
ILE A  61
 None
 0.96A 1oniD-3mruA:
undetectable
1oniF-3mruA:
undetectable		 1oniD-3mruA:
16.56
1oniF-3mruA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		5 / 12 TRP A  17
LEU A  16
LEU A 116
GLY A 117
VAL A 109
 None
 1.16A 1tsnA-3mruA:
undetectable		 1tsnA-3mruA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		4 / 6 LEU A 246
VAL A 362
VAL A 268
ILE A 325
 None
 1.07A 2hyyB-3mruA:
undetectable		 2hyyB-3mruA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		4 / 6 PRO A  27
HIS A  32
ASP A 148
ASP A  82
 None
 1.26A 2lh8A-3mruA:
undetectable		 2lh8A-3mruA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		4 / 4 ARG A 337
GLY A 375
GLU A 347
SER A 385
 None
 1.20A 2xctS-3mruA:
2.1
2xctU-3mruA:
2.3		 2xctS-3mruA:
21.53
2xctU-3mruA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		5 / 12 PHE A 267
GLY A 256
ILE A 262
ASN A 230
ASP A 223
 None
 1.25A 2zznB-3mruA:
undetectable		 2zznB-3mruA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		3 / 3 GLY A 152
ASP A 148
SER A  30
 None
 0.63A 3brfA-3mruA:
undetectable		 3brfA-3mruA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		4 / 6 GLY A 190
THR A 363
GLU A 380
GLU A 388
 None
 0.98A 3fpjA-3mruA:
undetectable		 3fpjA-3mruA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		4 / 6 LEU A 246
VAL A 362
VAL A 268
ILE A 325
 None
 1.04A 3k5vA-3mruA:
undetectable		 3k5vA-3mruA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		4 / 6 LEU A 246
VAL A 362
VAL A 268
ILE A 325
 None
 1.10A 3k5vB-3mruA:
undetectable		 3k5vB-3mruA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		5 / 12 VAL A 345
LEU A 436
GLY A 186
ALA A 185
LEU A 371
 None
 1.29A 3pghA-3mruA:
undetectable		 3pghA-3mruA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		3 / 3 LEU A 383
ARG A 369
ASN A 230
 None
 0.73A 3qxvD-3mruA:
undetectable		 3qxvD-3mruA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		5 / 9 GLY A 121
ALA A 118
ASP A 119
GLY A 454
ILE A 469
 None
None
ZN  A 492 ( 2.4A)
None
None
 0.89A 3s53A-3mruA:
undetectable		 3s53A-3mruA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		3 / 3 ARG A 198
GLU A 358
THR A 357
 None
 0.68A 3v4tA-3mruA:
undetectable		 3v4tA-3mruA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		3 / 3 TYR A 103
THR A 110
GLU A   3
 None
 0.82A 4df3A-3mruA:
undetectable		 4df3A-3mruA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		3 / 3 TYR A 103
THR A 110
GLU A   3
 None
 0.80A 4df3B-3mruA:
undetectable		 4df3B-3mruA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		4 / 8 ILE A 100
ILE A  26
LEU A  36
ILE A  23
 None
 0.92A 4dtaB-3mruA:
undetectable		 4dtaB-3mruA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		4 / 7 GLU A 294
LEU A 291
TYR A 287
LEU A 234
 None
 0.99A 4iomA-3mruA:
undetectable		 4iomA-3mruA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		3 / 3 SER A 174
TYR A 181
PRO A 460
 None
 0.89A 4k8cA-3mruA:
undetectable		 4k8cA-3mruA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		3 / 3 SER A 174
TYR A 181
PRO A 460
 None
 0.89A 4kahA-3mruA:
undetectable		 4kahA-3mruA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		3 / 3 SER A 174
TYR A 181
PRO A 460
 None
 0.89A 4kahB-3mruA:
undetectable		 4kahB-3mruA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		3 / 3 SER A 174
TYR A 181
PRO A 460
 None
 0.90A 4kanA-3mruA:
undetectable		 4kanA-3mruA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		3 / 3 SER A 174
TYR A 181
PRO A 460
 None
 0.89A 4kanB-3mruA:
undetectable		 4kanB-3mruA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		3 / 3 SER A 174
TYR A 181
PRO A 460
 None
 0.89A 4kbeA-3mruA:
undetectable		 4kbeA-3mruA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		3 / 3 SER A 174
TYR A 181
PRO A 460
 None
 0.88A 4kbeB-3mruA:
undetectable		 4kbeB-3mruA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		3 / 3 SER A 174
TYR A 181
PRO A 460
 None
 0.88A 4lbgA-3mruA:
undetectable		 4lbgA-3mruA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		3 / 3 SER A 174
TYR A 181
PRO A 460
 None
 0.88A 4lbgB-3mruA:
undetectable		 4lbgB-3mruA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		4 / 5 SER A 385
ARG A 337
GLY A 375
GLU A 347
 None
 1.18A 5cdqA-3mruA:
undetectable
5cdqB-3mruA:
2.6
5cdqC-3mruA:
undetectable		 5cdqA-3mruA:
22.41
5cdqB-3mruA:
16.63
5cdqC-3mruA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		4 / 5 SER A 385
ARG A 337
GLY A 375
GLU A 347
 None
 1.18A 5cdqR-3mruA:
undetectable
5cdqS-3mruA:
2.6
5cdqT-3mruA:
undetectable		 5cdqR-3mruA:
22.41
5cdqS-3mruA:
16.63
5cdqT-3mruA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		5 / 10 LEU A 290
GLU A 294
LEU A 295
ARG A 237
GLY A 214
 None
 1.40A 5dx3A-3mruA:
undetectable		 5dx3A-3mruA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		5 / 12 GLY A 121
ALA A 118
ASP A 119
GLY A 454
ILE A 469
 None
None
ZN  A 492 ( 2.4A)
None
None
 0.85A 5e5kB-3mruA:
undetectable		 5e5kB-3mruA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		5 / 12 ILE A 235
GLY A 236
PHE A 316
LEU A 210
VAL A 270
 None
 0.94A 5hw4A-3mruA:
undetectable		 5hw4A-3mruA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		5 / 11 ILE A 235
GLY A 236
PHE A 316
LEU A 210
VAL A 270
 None
 0.98A 5hw4B-3mruA:
undetectable		 5hw4B-3mruA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		5 / 12 ILE A 235
GLY A 236
PHE A 316
LEU A 210
VAL A 270
 None
 0.97A 5hw4C-3mruA:
undetectable		 5hw4C-3mruA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		4 / 4 GLN A 378
VAL A 379
GLU A 380
ILE A 368
 None
 1.18A 5jncA-3mruA:
undetectable		 5jncA-3mruA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		4 / 5 GLY A 113
THR A 114
ASN A  88
LYS A  87
 None
 1.19A 5x23A-3mruA:
undetectable		 5x23A-3mruA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		3 / 3 ARG A 376
ILE A 368
SER A 370
 None
 0.74A 5zw2A-3mruA:
undetectable		 5zw2A-3mruA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3mru AMINOACYL-HISTIDINE
DIPEPTIDASE
(Vibrio
alginolyticus) 		5 / 10 VAL A 130
ALA A 129
LEU A  77
LEU A 482
LEU A 483
 None
 0.88A 6f6nA-3mruA:
undetectable
6f6nB-3mruA:
undetectable		 6f6nA-3mruA:
10.56
6f6nB-3mruA:
9.57