SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		4 / 6 TYR A 211
VAL A  97
ILE A  73
LEU A 136
 None
EDO  A 235 (-3.9A)
None
None
 1.21A 1j96A-3mstA:
undetectable		 1j96A-3mstA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		5 / 12 GLY A   4
ASP A  41
ASN A  45
ILE A  26
LEU A  16
 None
 1.23A 1lhuA-3mstA:
undetectable		 1lhuA-3mstA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		6 / 12 ALA A 171
ILE A 163
GLY A 191
ILE A 192
PRO A  10
ILE A 174
 None
None
None
None
ACT  A 232 (-4.6A)
None
 1.34A 1muiB-3mstA:
undetectable		 1muiB-3mstA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		5 / 12 LEU A 218
LEU A 138
PRO A 139
THR A 198
ILE A 223
 None
None
None
CL  A 230 ( 4.8A)
CL  A 228 (-4.6A)
 1.16A 1mx8A-3mstA:
undetectable		 1mx8A-3mstA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		6 / 11 ALA A 171
ILE A 163
GLY A 191
ILE A 192
PRO A  10
ILE A 174
 None
None
None
None
ACT  A 232 (-4.6A)
None
 1.27A 1sdvB-3mstA:
undetectable		 1sdvB-3mstA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		6 / 12 ALA A 171
ILE A 163
GLY A 191
ILE A 192
PRO A  10
ILE A 174
 None
None
None
None
ACT  A 232 (-4.6A)
None
 1.22A 2r5pD-3mstA:
undetectable		 2r5pD-3mstA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		5 / 12 LEU A  81
TYR A 193
ILE A 121
GLY A 118
GLY A 102
 UNL  A 226 ( 4.8A)
None
None
ACT  A 232 ( 3.8A)
EDO  A 236 (-3.7A)
 0.94A 3bwcB-3mstA:
undetectable		 3bwcB-3mstA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		5 / 9 ALA A 171
GLY A 191
ILE A 192
PRO A  10
ILE A 174
 None
None
None
ACT  A 232 (-4.6A)
None
 1.12A 3ekvB-3mstA:
undetectable		 3ekvB-3mstA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		5 / 12 VAL A  57
GLY A 194
ILE A 189
ILE A 174
TYR A 181
 None
 0.99A 3mb5A-3mstA:
undetectable		 3mb5A-3mstA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		6 / 10 ALA A 171
ILE A 163
GLY A 191
ILE A 192
PRO A  10
ILE A 174
 None
None
None
None
ACT  A 232 (-4.6A)
None
 1.16A 3nujA-3mstA:
undetectable		 3nujA-3mstA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		6 / 9 ALA A 171
ILE A 163
GLY A 191
ILE A 192
PRO A  10
ILE A 174
 None
None
None
None
ACT  A 232 (-4.6A)
None
 1.20A 3nuoA-3mstA:
undetectable		 3nuoA-3mstA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		5 / 10 ALA A 171
ILE A 163
GLY A 191
PRO A  10
ILE A 174
 None
None
None
ACT  A 232 (-4.6A)
None
 1.05A 3oxvB-3mstA:
undetectable		 3oxvB-3mstA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		5 / 12 GLY A 159
ALA A 155
ILE A 160
VAL A  17
ILE A 174
 None
EDO  A 233 (-3.8A)
None
None
None
 0.90A 4ax8A-3mstA:
undetectable		 4ax8A-3mstA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		5 / 12 GLY A 159
ALA A 155
ILE A 160
VAL A  17
ILE A 174
 None
EDO  A 233 (-3.8A)
None
None
None
 0.92A 4azvA-3mstA:
undetectable		 4azvA-3mstA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		6 / 12 ALA A 171
ILE A 163
GLY A 191
ILE A 192
PRO A  10
ILE A 174
 None
None
None
None
ACT  A 232 (-4.6A)
None
 1.21A 4dqbA-3mstA:
undetectable		 4dqbA-3mstA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		6 / 12 ALA A 171
ILE A 163
GLY A 191
ILE A 192
PRO A  10
ILE A 174
 None
None
None
None
ACT  A 232 (-4.6A)
None
 1.18A 4dqfA-3mstA:
undetectable		 4dqfA-3mstA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		5 / 10 ALA A 171
GLY A 191
ILE A 192
PRO A  10
ILE A 174
 None
None
None
ACT  A 232 (-4.6A)
None
 1.12A 4q1wB-3mstA:
undetectable		 4q1wB-3mstA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		3 / 3 TYR A 181
GLY A   9
PRO A  10
 None
ACT  A 232 ( 4.8A)
ACT  A 232 (-4.6A)
 0.66A 4qwpA-3mstA:
undetectable		 4qwpA-3mstA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		6 / 11 ALA A 171
ILE A 163
GLY A 191
ILE A 192
PRO A  10
ILE A 174
 None
None
None
None
ACT  A 232 (-4.6A)
None
 1.13A 4rvjA-3mstA:
undetectable		 4rvjA-3mstA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		6 / 11 ALA A 171
ILE A 163
GLY A 191
ILE A 192
PRO A  10
ILE A 174
 None
None
None
None
ACT  A 232 (-4.6A)
None
 1.14A 4rvjC-3mstA:
undetectable		 4rvjC-3mstA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		5 / 12 GLY A 159
ALA A 155
ILE A 163
VAL A  17
ILE A 174
 None
EDO  A 233 (-3.8A)
None
None
None
 1.03A 4uw0A-3mstA:
undetectable		 4uw0A-3mstA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		4 / 7 ASN A 110
LYS A 107
TYR A  74
PHE A 127
 None
None
None
UNL  A 226 ( 4.6A)
 1.15A 4yv5B-3mstA:
undetectable		 4yv5B-3mstA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		4 / 5 TYR A  62
GLY A   9
TYR A 193
GLY A 194
 ACT  A 232 ( 4.6A)
ACT  A 232 ( 4.8A)
None
None
 1.00A 5ayfA-3mstA:
undetectable		 5ayfA-3mstA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		4 / 5 SER A 140
ARG A 130
GLU A  68
ARG A 128
 UNL  A 226 (-2.9A)
None
None
CL  A 227 (-2.7A)
 1.07A 5cdqA-3mstA:
undetectable
5cdqB-3mstA:
undetectable
5cdqC-3mstA:
undetectable		 5cdqA-3mstA:
20.49
5cdqB-3mstA:
21.57
5cdqC-3mstA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		4 / 5 SER A 140
ARG A 130
GLU A  68
ARG A 128
 UNL  A 226 (-2.9A)
None
None
CL  A 227 (-2.7A)
 1.12A 5cdqR-3mstA:
undetectable
5cdqS-3mstA:
undetectable
5cdqT-3mstA:
undetectable		 5cdqR-3mstA:
20.49
5cdqS-3mstA:
21.57
5cdqT-3mstA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		5 / 9 ILE A  43
GLY A  56
THR A 198
LEU A 204
LEU A 138
 None
None
CL  A 230 ( 4.8A)
None
None
 1.09A 5fhzB-3mstA:
undetectable		 5fhzB-3mstA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		5 / 10 ILE A  43
GLY A  56
THR A 198
LEU A 204
LEU A 138
 None
None
CL  A 230 ( 4.8A)
None
None
 1.06A 5fhzC-3mstA:
undetectable		 5fhzC-3mstA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		5 / 9 ALA A 171
ILE A 163
GLY A 191
ILE A 192
PRO A  10
 None
None
None
None
ACT  A 232 (-4.6A)
 1.10A 5kr0A-3mstA:
undetectable		 5kr0A-3mstA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 3mst PUTATIVE NITRATE
TRANSPORT PROTEIN
(Thermoplasma
volcanium) 		5 / 9 ILE A 163
GLY A 191
ILE A 192
PRO A  10
ILE A 174
 None
None
None
ACT  A 232 (-4.6A)
None
 1.06A 5kr0A-3mstA:
undetectable		 5kr0A-3mstA:
17.00