SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3msu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 LEU A  95
HIS A  74
ASP A 230
LEU A  72
GLY A  76
 None
 1.29A 1d4fA-3msuA:
undetectable		 1d4fA-3msuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 LEU A  95
HIS A  74
ASP A 230
LEU A  72
GLY A  76
 None
 1.32A 1d4fB-3msuA:
undetectable		 1d4fB-3msuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 LEU A  95
HIS A  74
ASP A 230
LEU A  72
GLY A  76
 None
 1.33A 1d4fC-3msuA:
undetectable		 1d4fC-3msuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 ALA A 175
ALA A 176
LEU A 388
ALA A 384
ILE A 218
 None
 0.80A 1fm6U-3msuA:
undetectable		 1fm6U-3msuA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		4 / 7 TYR A 251
ILE A  96
HIS A 151
GLU A 158
 CL  A 432 ( 4.3A)
None
None
None
 0.96A 1j96B-3msuA:
undetectable		 1j96B-3msuA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 ILE A  45
ILE A  19
ILE A  21
VAL A  37
LEU A  23
 None
 0.88A 1qhsA-3msuA:
undetectable		 1qhsA-3msuA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 ILE A  45
ILE A  19
ILE A  21
VAL A  37
LEU A  23
 None
 0.94A 1qhyA-3msuA:
undetectable		 1qhyA-3msuA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 11 HIS A 307
ALA A 269
VAL A 364
ILE A 224
PHE A 386
 None
 1.18A 2h42A-3msuA:
undetectable		 2h42A-3msuA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		4 / 7 ALA A 172
THR A 173
ALA A 176
PRO A 118
 None
 0.97A 2ql8A-3msuA:
undetectable
2ql8B-3msuA:
undetectable		 2ql8A-3msuA:
16.99
2ql8B-3msuA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 10 ALA A 175
ALA A 176
LEU A 388
ALA A 384
ILE A 218
 None
 0.96A 3falC-3msuA:
undetectable		 3falC-3msuA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 11 ALA A 175
ALA A 176
LEU A 388
ALA A 384
ILE A 218
 None
 0.93A 3fc6A-3msuA:
undetectable		 3fc6A-3msuA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 LEU A  95
HIS A  74
ASP A 230
LEU A  72
GLY A  76
 None
 1.37A 3g1uB-3msuA:
undetectable		 3g1uB-3msuA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 LEU A  95
HIS A  74
ASP A 230
LEU A  72
GLY A  76
 None
 1.39A 3g1uC-3msuA:
undetectable		 3g1uC-3msuA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 LEU A  95
HIS A  74
ASP A 230
LEU A  72
GLY A  76
 None
 1.29A 3glqA-3msuA:
undetectable		 3glqA-3msuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 TYR A  88
TYR A 196
PHE A 109
ALA A 164
MET A 226
 OAA  A 430 (-4.4A)
OAA  A 430 (-4.5A)
OAA  A 430 (-4.5A)
None
None
 1.36A 3ld6A-3msuA:
undetectable		 3ld6A-3msuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 TYR A  88
TYR A 196
PHE A 109
ALA A 164
MET A 226
 OAA  A 430 (-4.4A)
OAA  A 430 (-4.5A)
OAA  A 430 (-4.5A)
None
None
 1.33A 3ld6B-3msuA:
undetectable		 3ld6B-3msuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 LEU A  95
HIS A  74
ASP A 230
LEU A  72
GLY A  76
 None
 1.24A 3n58A-3msuA:
undetectable		 3n58A-3msuA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 ALA A 175
ALA A 176
LEU A 388
ALA A 384
ILE A 218
 None
 0.82A 3oapA-3msuA:
undetectable		 3oapA-3msuA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 HIS A 135
LEU A 261
GLY A 263
ALA A 384
ALA A 387
 None
 1.03A 3sufA-3msuA:
undetectable		 3sufA-3msuA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		3 / 3 LYS A 219
THR A 223
ILE A  79
 None
 0.85A 4e0fB-3msuA:
undetectable		 4e0fB-3msuA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		3 / 3 HIS A 228
TRP A 394
SER A 368
 None
 1.15A 4lrhD-3msuA:
undetectable		 4lrhD-3msuA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 ALA A 175
ALA A 176
LEU A 388
ALA A 384
ILE A 218
 None
 0.80A 4nqaH-3msuA:
undetectable		 4nqaH-3msuA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 10 LEU A 372
GLY A 369
ASN A 363
ALA A 389
ILE A 385
 None
 1.13A 4xj7C-3msuA:
undetectable
4xj7D-3msuA:
undetectable		 4xj7C-3msuA:
19.86
4xj7D-3msuA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 11 GLY A 393
ASP A 230
ALA A 229
TRP A 398
VAL A 168
 None
 1.39A 5c8tB-3msuA:
undetectable		 5c8tB-3msuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		4 / 8 ALA A 148
VAL A 144
VAL A 163
GLU A 158
 None
 0.90A 5ecnD-3msuA:
undetectable		 5ecnD-3msuA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 MET A 204
PHE A 200
ILE A 371
ALA A 220
ALA A 197
 None
None
None
None
OAA  A 430 ( 4.4A)
 1.14A 5oy02-3msuA:
undetectable		 5oy02-3msuA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		4 / 5 LEU A 338
ALA A 342
LEU A 345
LEU A 331
 None
 0.86A 5vkqA-3msuA:
undetectable
5vkqD-3msuA:
undetectable		 5vkqA-3msuA:
13.74
5vkqD-3msuA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		4 / 5 LEU A 331
LEU A 338
ALA A 342
LEU A 345
 None
 0.85A 5vkqA-3msuA:
undetectable
5vkqB-3msuA:
undetectable		 5vkqA-3msuA:
13.74
5vkqB-3msuA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		4 / 5 LEU A 331
LEU A 338
ALA A 342
LEU A 345
 None
 0.83A 5vkqB-3msuA:
undetectable
5vkqC-3msuA:
undetectable		 5vkqB-3msuA:
13.74
5vkqC-3msuA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		4 / 5 LEU A 331
LEU A 338
ALA A 342
LEU A 345
 None
 0.88A 5vkqC-3msuA:
undetectable
5vkqD-3msuA:
undetectable		 5vkqC-3msuA:
13.74
5vkqD-3msuA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 ALA A 175
ALA A 176
LEU A 388
ALA A 384
ILE A 218
 None
 0.87A 6a5yD-3msuA:
undetectable		 6a5yD-3msuA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 ALA A 175
ALA A 176
LEU A 388
ALA A 384
ILE A 218
 None
 0.80A 6a5zD-3msuA:
undetectable		 6a5zD-3msuA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 ALA A 175
ALA A 176
LEU A 388
ALA A 384
ILE A 218
 None
 0.81A 6a5zL-3msuA:
undetectable		 6a5zL-3msuA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 LEU A  95
HIS A  74
ASP A 230
LEU A  72
GLY A  76
 None
 1.37A 6aphA-3msuA:
undetectable		 6aphA-3msuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 LEU A  23
HIS A  43
LEU A  40
LEU A  12
THR A  11
 None
 0.85A 6b0cD-3msuA:
undetectable		 6b0cD-3msuA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 12 LEU A  95
HIS A  74
ASP A 230
LEU A  72
GLY A  76
 None
 1.30A 6gbnB-3msuA:
undetectable		 6gbnB-3msuA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		5 / 11 PHE A 225
THR A 173
THR A 391
ILE A 395
VAL A 168
 None
 1.49A 6hcoA-3msuA:
undetectable
6hcoB-3msuA:
0.4		 6hcoA-3msuA:
20.75
6hcoB-3msuA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		4 / 5 HIS A 231
ARG A 316
PHE A 386
ARG A 390
 None
 0.53A 6hxiB-3msuA:
16.8		 6hxiB-3msuA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		4 / 5 HIS A 231
ARG A 316
ASP A 365
PHE A 386
 None
 0.81A 6hxiD-3msuA:
16.2		 6hxiD-3msuA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 3msu CITRATE SYNTHASE
(Francisella
tularensis) 		4 / 5 HIS A 231
ARG A 316
PHE A 386
ARG A 390
 None
 0.53A 6hxiD-3msuA:
16.2		 6hxiD-3msuA:
22.62