SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3msy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(marine
actinobacterium
PHSC20C1) 		4 / 6 GLU A 320
THR A 127
ALA A 123
LEU A 119
 None
 1.26A 1etb2-3msyA:
undetectable		 1etb2-3msyA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(marine
actinobacterium
PHSC20C1) 		4 / 5 LEU A 328
ILE A 157
ARG A 344
TRP A 349
 None
 1.13A 2zlcA-3msyA:
undetectable		 2zlcA-3msyA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(marine
actinobacterium
PHSC20C1) 		3 / 3 GLU A 320
GLU A 319
TRP A 294
 None
 1.25A 3hrdA-3msyA:
undetectable
3hrdE-3msyA:
undetectable
3hrdF-3msyA:
undetectable		 3hrdA-3msyA:
23.01
3hrdE-3msyA:
23.01
3hrdF-3msyA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(marine
actinobacterium
PHSC20C1) 		5 / 10 VAL A 183
ALA A 205
ARG A 203
ILE A 168
ILE A 212
 None
 1.43A 3retA-3msyA:
undetectable
3retB-3msyA:
undetectable		 3retA-3msyA:
16.00
3retB-3msyA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(marine
actinobacterium
PHSC20C1) 		5 / 12 ALA A 329
HIS A 326
LEU A 327
GLY A 146
PRO A 332
 None
 1.34A 3tm4A-3msyA:
undetectable		 3tm4A-3msyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(marine
actinobacterium
PHSC20C1) 		5 / 12 ALA A 329
HIS A 326
LEU A 327
GLY A 146
PRO A 332
 None
 1.32A 3tm4B-3msyA:
undetectable		 3tm4B-3msyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(marine
actinobacterium
PHSC20C1) 		4 / 5 ASP A 278
THR A 282
LEU A 279
GLU A 270
 None
 1.08A 4a3pA-3msyA:
undetectable		 4a3pA-3msyA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(marine
actinobacterium
PHSC20C1) 		5 / 12 MET A  95
LEU A 141
ILE A  28
ILE A  61
LEU A 137
 None
 1.19A 4j26B-3msyA:
undetectable		 4j26B-3msyA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(marine
actinobacterium
PHSC20C1) 		4 / 4 GLU A  64
GLY A  63
HIS A  56
ARG A  54
 None
 1.25A 4r82A-3msyA:
undetectable
4r82B-3msyA:
undetectable		 4r82A-3msyA:
19.89
4r82B-3msyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(marine
actinobacterium
PHSC20C1) 		5 / 12 ASP A 195
VAL A 183
ILE A 212
LEU A 228
ILE A 232
 None
 1.11A 5b8iC-3msyA:
undetectable		 5b8iC-3msyA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(marine
actinobacterium
PHSC20C1) 		4 / 8 ASP A 291
HIS A 317
GLU A 241
ASP A 215
 None
 1.14A 6mn4B-3msyA:
undetectable		 6mn4B-3msyA:
20.64