SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mtj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 12 GLU A 432
ILE A 267
PRO A 268
ILE A 273
THR A 265
 None
 1.11A 1kijA-3mtjA:
undetectable		 1kijA-3mtjA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 12 GLU A 432
ILE A 267
PRO A 268
ILE A 273
THR A 265
 None
 1.11A 1kijB-3mtjA:
undetectable		 1kijB-3mtjA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  16
GLY A  15
VAL A  76
LEU A   8
LEU A  78
 None
 0.78A 1mx1D-3mtjA:
undetectable		 1mx1D-3mtjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  16
GLY A  15
VAL A  76
LEU A   8
LEU A  78
 None
 0.66A 1mx1F-3mtjA:
undetectable		 1mx1F-3mtjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A  17
GLY A  15
VAL A  76
LEU A   8
LEU A  78
 None
 0.90A 1mx1F-3mtjA:
undetectable		 1mx1F-3mtjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 11 GLY A 198
SER A 161
ILE A 156
PRO A 264
ILE A 245
 None
 1.05A 2nnhA-3mtjA:
undetectable		 2nnhA-3mtjA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		3 / 3 LYS A 121
LYS A  97
VAL A 123
 None
 1.01A 3brfA-3mtjA:
undetectable		 3brfA-3mtjA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		3 / 3 HIS A 263
ARG A 430
GLU A 432
 None
 0.97A 3qf1A-3mtjA:
undetectable		 3qf1A-3mtjA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		4 / 4 LEU A  11
GLY A  12
GLY A  16
THR A  18
 None
 0.77A 3si7A-3mtjA:
undetectable		 3si7A-3mtjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		4 / 5 LEU A  11
GLY A  12
GLY A  16
THR A  18
 None
 0.78A 3si7C-3mtjA:
undetectable
3si7D-3mtjA:
undetectable		 3si7C-3mtjA:
20.27
3si7D-3mtjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 12 GLY A 159
GLY A 299
TYR A 296
LEU A 294
ALA A 274
 None
 1.18A 3t7vA-3mtjA:
undetectable		 3t7vA-3mtjA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 12 ALA A 201
LEU A 205
VAL A 283
LEU A 153
ILE A 138
 None
 1.15A 4g1bA-3mtjA:
5.0		 4g1bA-3mtjA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 10 GLY A   7
VAL A   6
VAL A  39
LEU A  78
LEU A  22
 None
 1.17A 4yb6A-3mtjA:
undetectable
4yb6E-3mtjA:
undetectable		 4yb6A-3mtjA:
22.61
4yb6E-3mtjA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 10 GLY A   7
VAL A   6
VAL A  39
LEU A  78
LEU A  22
 None
 1.15A 4yb6B-3mtjA:
undetectable
4yb6C-3mtjA:
0.6		 4yb6B-3mtjA:
22.61
4yb6C-3mtjA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 10 GLY A   7
VAL A   6
VAL A  39
LEU A  78
LEU A  22
 None
 1.13A 4yb6C-3mtjA:
undetectable
4yb6F-3mtjA:
undetectable		 4yb6C-3mtjA:
22.61
4yb6F-3mtjA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 10 LEU A  78
LEU A  22
GLY A   7
VAL A   6
VAL A  39
 None
 1.13A 4yb6A-3mtjA:
undetectable
4yb6D-3mtjA:
undetectable		 4yb6A-3mtjA:
22.61
4yb6D-3mtjA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 10 LEU A  78
LEU A  22
GLY A   7
VAL A   6
VAL A  39
 None
 1.14A 4yb6D-3mtjA:
undetectable
4yb6E-3mtjA:
undetectable		 4yb6D-3mtjA:
22.61
4yb6E-3mtjA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 10 LEU A  78
LEU A  22
GLY A   7
VAL A   6
VAL A  39
 None
 1.17A 4yb6B-3mtjA:
undetectable
4yb6F-3mtjA:
undetectable		 4yb6B-3mtjA:
22.61
4yb6F-3mtjA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		4 / 6 ARG A  35
ASP A  73
LYS A  97
HIS A  98
 SO4  A 438 (-3.2A)
SO4  A 438 ( 4.6A)
None
None
 1.09A 5a06A-3mtjA:
5.6		 5a06A-3mtjA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		4 / 5 ILE A 157
LEU A 165
HIS A 263
VAL A 262
 None
 1.24A 5jmnB-3mtjA:
2.5		 5jmnB-3mtjA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 10 ALA A 308
ILE A  37
ILE A  74
VAL A  76
ALA A 129
 None
 1.13A 5nukA-3mtjA:
undetectable		 5nukA-3mtjA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		3 / 3 LYS A 109
HIS A 203
HIS A 105
 None
 1.23A 5oexA-3mtjA:
undetectable		 5oexA-3mtjA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		3 / 3 LYS A 109
HIS A 203
HIS A 105
 None
 1.21A 5oexB-3mtjA:
undetectable		 5oexB-3mtjA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		3 / 3 LYS A 109
HIS A 203
HIS A 105
 None
 1.22A 5oexC-3mtjA:
undetectable		 5oexC-3mtjA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		3 / 3 LYS A 109
HIS A 203
HIS A 105
 None
 1.20A 5oexD-3mtjA:
undetectable		 5oexD-3mtjA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		3 / 3 GLY A  81
LEU A  82
HIS A 105
 None
 0.68A 5u63B-3mtjA:
undetectable		 5u63B-3mtjA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 9 ALA A 130
VAL A 309
ALA A 308
VAL A  14
GLY A 134
 None
 1.22A 6bklA-3mtjA:
undetectable
6bklB-3mtjA:
undetectable
6bklC-3mtjA:
undetectable
6bklD-3mtjA:
undetectable		 6bklA-3mtjA:
4.78
6bklB-3mtjA:
4.78
6bklC-3mtjA:
4.78
6bklD-3mtjA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 3mtj HOMOSERINE
DEHYDROGENASE
(Thiobacillus
denitrificans) 		5 / 9 ASN A 112
ILE A 207
ILE A 211
VAL A 131
ILE A 138
 None
 1.39A 6hloA-3mtjA:
5.9		 6hloA-3mtjA:
22.36