SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mtl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A 171
GLY A 172
VAL A 179
ALA A 192
VAL A 224
ASN A 291
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-3.9A)
FEF  A 668 (-4.2A)
 0.68A 1fmoE-3mtlA:
23.8		 1fmoE-3mtlA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		6 / 9 LEU A 171
GLY A 172
VAL A 179
ALA A 192
TYR A 242
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
 0.76A 1muoA-3mtlA:
10.4		 1muoA-3mtlA:
27.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		8 / 12 VAL A 179
LYS A 194
VAL A 224
PHE A 240
ASP A 246
ASN A 291
LEU A 293
ALA A 303
 FEF  A 668 (-4.9A)
None
FEF  A 668 (-4.7A)
FEF  A 668 ( 4.3A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-3.9A)
FEF  A 668 (-4.2A)
FEF  A 668 ( 4.0A)
 0.76A 2eufB-3mtlA:
29.6		 2eufB-3mtlA:
40.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		6 / 12 LEU A 171
GLY A 172
VAL A 179
ALA A 192
TYR A 242
ASN A 291
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-3.9A)
 0.61A 2fumC-3mtlA:
23.0		 2fumC-3mtlA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		7 / 12 LEU A 171
GLY A 172
GLY A 174
VAL A 179
ALA A 192
LYS A 288
ASN A 291
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
None
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 ( 4.9A)
FEF  A 668 (-3.9A)
 0.76A 2fumD-3mtlA:
15.8		 2fumD-3mtlA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		5 / 11 MET A 355
ILE A 258
LEU A 300
ILE A 294
LEU A 470
 None
 1.29A 3a50C-3mtlA:
undetectable		 3a50C-3mtlA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		5 / 9 LEU A 171
VAL A 179
LYS A 194
VAL A 224
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 (-4.9A)
None
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
 0.85A 3cs9B-3mtlA:
15.2		 3cs9B-3mtlA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		4 / 6 LEU A 171
VAL A 179
LYS A 194
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 (-4.9A)
None
FEF  A 668 (-4.2A)
 0.82A 3cs9D-3mtlA:
20.3		 3cs9D-3mtlA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		5 / 12 PHE A 240
ALA A 177
ALA A 303
VAL A 224
ILE A 209
 FEF  A 668 ( 4.3A)
None
FEF  A 668 ( 4.0A)
FEF  A 668 (-4.7A)
None
 1.13A 3czhA-3mtlA:
undetectable		 3czhA-3mtlA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		9 / 12 LEU A 171
GLY A 172
GLY A 174
VAL A 179
ALA A 192
VAL A 224
TYR A 242
LEU A 243
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
None
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.3A)
FEF  A 668 (-4.2A)
 0.60A 3fupB-3mtlA:
22.3		 3fupB-3mtlA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		8 / 12 LEU A 171
VAL A 179
ALA A 192
LYS A 194
VAL A 224
TYR A 242
LEU A 243
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
None
FEF  A 668 (-4.7A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.3A)
FEF  A 668 (-4.2A)
 0.75A 3fupB-3mtlA:
22.3		 3fupB-3mtlA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		6 / 11 LEU A 171
VAL A 179
ALA A 192
VAL A 224
TYR A 242
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
 0.50A 3g0eA-3mtlA:
20.4		 3g0eA-3mtlA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		6 / 11 LEU A 171
VAL A 179
ALA A 192
TYR A 242
ASP A 246
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-4.2A)
 0.72A 3g0fA-3mtlA:
21.0		 3g0fA-3mtlA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		9 / 12 LEU A 171
GLY A 172
VAL A 179
ALA A 192
LYS A 194
VAL A 224
TYR A 242
LEU A 293
ALA A 303
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
None
FEF  A 668 (-4.7A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
FEF  A 668 ( 4.0A)
 0.98A 3lxkA-3mtlA:
22.8		 3lxkA-3mtlA:
27.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		5 / 9 ALA A 192
VAL A 224
PHE A 240
ASP A 246
LEU A 293
 FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 ( 4.3A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-4.2A)
 0.69A 3ti1A-3mtlA:
31.2		 3ti1A-3mtlA:
51.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		5 / 12 LEU A 415
LEU A 427
PHE A 445
LEU A 270
LEU A 267
 None
 1.06A 3vw7A-3mtlA:
2.2		 3vw7A-3mtlA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		4 / 5 ILE A 462
ALA A 464
HIS A 454
ARG A 452
 None
 1.28A 4ac9B-3mtlA:
undetectable
4ac9C-3mtlA:
undetectable		 4ac9B-3mtlA:
21.77
4ac9C-3mtlA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		4 / 5 ILE A 258
ALA A 356
HIS A 261
MET A 260
 None
 1.13A 4acaB-3mtlA:
undetectable
4acaC-3mtlA:
undetectable		 4acaB-3mtlA:
21.77
4acaC-3mtlA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		4 / 5 ILE A 462
ALA A 464
HIS A 454
ARG A 452
 None
 1.27A 4acaB-3mtlA:
undetectable
4acaC-3mtlA:
undetectable		 4acaB-3mtlA:
21.77
4acaC-3mtlA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		6 / 11 LEU A 171
GLY A 172
VAL A 179
ALA A 192
TYR A 242
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
 0.54A 4ckiA-3mtlA:
22.4		 4ckiA-3mtlA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		7 / 10 LEU A 171
GLY A 172
GLY A 174
VAL A 179
ALA A 192
TYR A 242
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
None
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
 0.64A 4ckjA-3mtlA:
22.4		 4ckjA-3mtlA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		4 / 7 VAL A 179
ALA A 192
ASP A 246
LEU A 293
 FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-4.2A)
 0.79A 4l9iA-3mtlA:
7.5		 4l9iA-3mtlA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		5 / 6 LEU A 171
GLY A 172
VAL A 179
ALA A 192
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.2A)
 0.62A 4o0wA-3mtlA:
18.5		 4o0wA-3mtlA:
27.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		5 / 8 VAL A 179
ALA A 192
ASP A 246
ASN A 291
LEU A 293
 FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-3.9A)
FEF  A 668 (-4.2A)
 0.53A 4ogrA-3mtlA:
30.4		 4ogrA-3mtlA:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		5 / 7 GLY A 172
ALA A 192
ASP A 246
ASN A 291
LEU A 293
 FEF  A 668 ( 4.2A)
FEF  A 668 (-3.3A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-3.9A)
FEF  A 668 (-4.2A)
 0.48A 4ogrE-3mtlA:
23.8		 4ogrE-3mtlA:
38.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		5 / 9 VAL A 348
ALA A 440
ARG A 272
ARG A 279
ILE A 435
 None
 1.25A 4oknB-3mtlA:
undetectable		 4oknB-3mtlA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		8 / 12 LEU A 171
GLY A 172
GLY A 174
VAL A 179
ALA A 192
LYS A 194
VAL A 224
ALA A 303
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
None
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
None
FEF  A 668 (-4.7A)
FEF  A 668 ( 4.0A)
 0.71A 4otiA-3mtlA:
15.6		 4otiA-3mtlA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		8 / 12 LEU A 171
GLY A 172
VAL A 179
ALA A 192
LYS A 194
VAL A 224
LEU A 293
ALA A 303
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
None
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
FEF  A 668 ( 4.0A)
 0.64A 4otiA-3mtlA:
15.6		 4otiA-3mtlA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		6 / 12 GLY A 172
VAL A 179
ALA A 192
TYR A 242
LEU A 243
LEU A 293
 FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.3A)
FEF  A 668 (-4.2A)
 0.61A 4qmzA-3mtlA:
23.5		 4qmzA-3mtlA:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		5 / 11 ILE A 332
THR A 337
SER A 336
GLY A 335
GLU A 430
 None
 1.26A 4xt7A-3mtlA:
undetectable		 4xt7A-3mtlA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		5 / 12 LEU A 270
LEU A 361
PRO A 329
ILE A 343
VAL A 263
 None
 1.28A 5dlvB-3mtlA:
undetectable		 5dlvB-3mtlA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		5 / 11 PHE A 445
VAL A 263
ILE A 462
ILE A 453
ILE A 468
 None
 1.04A 5hw8B-3mtlA:
undetectable		 5hw8B-3mtlA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		4 / 4 LEU A 371
ARG A 376
ILE A 374
PHE A 375
 None
 1.17A 5kirB-3mtlA:
undetectable		 5kirB-3mtlA:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		8 / 12 GLY A 172
VAL A 179
ALA A 192
VAL A 224
PHE A 240
ASP A 246
LEU A 293
ALA A 303
 FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 ( 4.3A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-4.2A)
FEF  A 668 ( 4.0A)
 0.56A 5l2iA-3mtlA:
18.0		 5l2iA-3mtlA:
39.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		7 / 12 GLY A 172
VAL A 179
ALA A 192
VAL A 224
PHE A 240
ASP A 246
LEU A 293
 FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 ( 4.3A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-4.2A)
 0.85A 5l2tA-3mtlA:
18.2		 5l2tA-3mtlA:
39.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		7 / 12 VAL A 179
ALA A 192
VAL A 224
PHE A 240
ASP A 246
LEU A 293
ALA A 303
 FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 ( 4.3A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-4.2A)
FEF  A 668 ( 4.0A)
 0.87A 5l2tA-3mtlA:
18.2		 5l2tA-3mtlA:
39.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		7 / 11 LEU A 171
GLY A 172
VAL A 179
ALA A 192
VAL A 224
TYR A 242
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
 0.62A 5lvnA-3mtlA:
24.9		 5lvnA-3mtlA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		6 / 10 LEU A 171
VAL A 179
ALA A 192
VAL A 224
TYR A 242
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
 0.64A 5n3hA-3mtlA:
24.0		 5n3hA-3mtlA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		6 / 12 LEU A 171
ALA A 192
LYS A 194
GLU A 211
VAL A 224
LEU A 238
 FEF  A 668 ( 3.8A)
FEF  A 668 (-3.3A)
None
None
FEF  A 668 (-4.7A)
None
 1.00A 5vcvA-3mtlA:
22.5		 5vcvA-3mtlA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A 172
VAL A 179
ALA A 192
PHE A 240
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 ( 4.3A)
 0.43A 5xv7A-3mtlA:
15.5		 5xv7A-3mtlA:
13.68