SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mtv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 8 HIS A 159
LEU A 168
LEU A 160
GLU A  87
 None
 1.05A 1i7zA-3mtvA:
undetectable		 1i7zA-3mtvA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 6 THR A  84
PHE A  60
PHE A 150
GLY A 170
 None
 0.92A 1icuA-3mtvA:
undetectable
1icuB-3mtvA:
undetectable		 1icuA-3mtvA:
20.89
1icuB-3mtvA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 6 PHE A 150
GLY A 170
THR A  84
PHE A  60
 None
 0.97A 1icuA-3mtvA:
undetectable
1icuB-3mtvA:
undetectable		 1icuA-3mtvA:
20.89
1icuB-3mtvA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 6 THR A  84
PHE A  60
PHE A 150
GLY A 170
 None
 0.96A 1icuC-3mtvA:
undetectable
1icuD-3mtvA:
undetectable		 1icuC-3mtvA:
20.89
1icuD-3mtvA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 5 PHE A 150
GLY A 170
THR A  84
PHE A  60
 None
 1.02A 1icuC-3mtvA:
undetectable
1icuD-3mtvA:
undetectable		 1icuC-3mtvA:
20.89
1icuD-3mtvA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 5 PHE A 150
GLY A 170
THR A  84
PHE A  60
 None
 1.00A 1icvA-3mtvA:
undetectable
1icvB-3mtvA:
undetectable		 1icvA-3mtvA:
20.89
1icvB-3mtvA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 6 THR A  84
PHE A  60
PHE A 150
GLY A 170
 None
 0.94A 1kqbA-3mtvA:
undetectable
1kqbB-3mtvA:
undetectable		 1kqbA-3mtvA:
21.98
1kqbB-3mtvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 6 THR A  84
PHE A  60
PHE A 150
GLY A 170
 None
 0.96A 1kqbC-3mtvA:
undetectable
1kqbD-3mtvA:
undetectable		 1kqbC-3mtvA:
21.98
1kqbD-3mtvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 6 PHE A 150
GLY A 170
THR A  84
PHE A  60
 None
 0.88A 1kqbC-3mtvA:
undetectable
1kqbD-3mtvA:
undetectable		 1kqbC-3mtvA:
21.98
1kqbD-3mtvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 8 LYS A 161
LEU A 160
GLN A 148
LEU A  94
 None
 0.89A 1v54P-3mtvA:
undetectable
1v54W-3mtvA:
undetectable		 1v54P-3mtvA:
19.92
1v54W-3mtvA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 7 LYS A 161
LEU A 160
GLN A 148
LEU A  94
 None
 0.93A 1v55P-3mtvA:
undetectable
1v55W-3mtvA:
undetectable		 1v55P-3mtvA:
19.92
1v55W-3mtvA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		3 / 3 THR A  84
PRO A  86
PRO A 169
 None
 0.86A 2d55C-3mtvA:
undetectable		 2d55C-3mtvA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 8 LYS A 161
LEU A 160
GLN A 148
LEU A  94
 None
 0.89A 2dyrP-3mtvA:
undetectable
2dyrW-3mtvA:
undetectable		 2dyrP-3mtvA:
19.92
2dyrW-3mtvA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 7 LYS A 161
LEU A 160
GLN A 148
LEU A  94
 None
 0.86A 2eijP-3mtvA:
undetectable
2eijW-3mtvA:
undetectable		 2eijP-3mtvA:
19.92
2eijW-3mtvA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 8 LYS A 161
LEU A 160
GLN A 148
LEU A  94
 None
 0.88A 2eikP-3mtvA:
undetectable
2eikW-3mtvA:
undetectable		 2eikP-3mtvA:
19.92
2eikW-3mtvA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 7 LYS A 161
LEU A 160
GLN A 148
LEU A  94
 None
 0.88A 2einC-3mtvA:
undetectable
2einJ-3mtvA:
undetectable		 2einC-3mtvA:
19.92
2einJ-3mtvA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		5 / 12 GLU A 164
LEU A 160
GLY A 143
VAL A 179
ALA A 137
 None
 1.36A 2kceA-3mtvA:
undetectable		 2kceA-3mtvA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 6 GLY A 170
PHE A 150
PRO A  86
THR A  84
 None
 1.17A 2m2oB-3mtvA:
undetectable		 2m2oB-3mtvA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 7 LYS A 161
LEU A 160
GLN A 148
LEU A  94
 None
 0.88A 2zxwC-3mtvA:
undetectable
2zxwJ-3mtvA:
undetectable		 2zxwC-3mtvA:
19.92
2zxwJ-3mtvA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 7 VAL A  14
TYR A   4
GLU A  37
PRO A  35
 None
 0.97A 3hs4A-3mtvA:
undetectable		 3hs4A-3mtvA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		4 / 6 LEU A 162
GLU A 165
PRO A 166
ARG A  93
 None
 1.27A 3ltwA-3mtvA:
undetectable		 3ltwA-3mtvA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		3 / 3 ARG A  72
HIS A  46
TYR A  75
 None
 1.15A 4fu8A-3mtvA:
undetectable		 4fu8A-3mtvA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		3 / 3 ARG A  72
HIS A  46
TYR A  75
 None
 1.29A 4fu9A-3mtvA:
undetectable		 4fu9A-3mtvA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3mtv PAPAIN-LIKE CYSTEINE
PROTEASE
(Porcine
reproductive
and
respiratory
syndrome
virus) 		3 / 3 GLY A 170
THR A 117
PRO A  86
 None
 0.52A 5v5zA-3mtvA:
undetectable		 5v5zA-3mtvA:
17.01