SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mtw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 5 HIS A  90
HIS A 252
HIS A 272
ASP A 344
 ZN  A   1 ( 3.2A)
ZN  A   2 ( 3.2A)
ZN  A   2 ( 3.3A)
M3R  A 430 ( 2.4A)
 0.78A 1e9yB-3mtwA:
19.3		 1e9yB-3mtwA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 6 HIS A  90
HIS A  92
HIS A 252
HIS A 272
ASP A 344
 ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.2A)
ZN  A   2 ( 3.2A)
ZN  A   2 ( 3.3A)
M3R  A 430 ( 2.4A)
 0.78A 1fweC-3mtwA:
19.8		 1fweC-3mtwA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 6 HIS A  90
HIS A 171
HIS A 252
HIS A 272
ASP A 344
 ZN  A   1 ( 3.2A)
M3R  A 430 (-3.9A)
ZN  A   2 ( 3.2A)
ZN  A   2 ( 3.3A)
M3R  A 430 ( 2.4A)
 1.25A 1fweC-3mtwA:
19.8		 1fweC-3mtwA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 5 SER A 274
TYR A 363
SER A 373
ASP A 294
 None
SO4  A   5 (-4.6A)
None
M3R  A 430 (-3.2A)
 1.39A 1vidA-3mtwA:
undetectable		 1vidA-3mtwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 6 SER A 274
TYR A 363
SER A 373
ASP A 294
 None
SO4  A   5 (-4.6A)
None
M3R  A 430 (-3.2A)
 1.40A 2cl5B-3mtwA:
undetectable		 2cl5B-3mtwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 8 ASP A 149
GLY A 143
GLU A 146
ILE A 158
 GOL  A   3 (-2.8A)
None
None
None
 0.80A 2dtjA-3mtwA:
undetectable
2dtjB-3mtwA:
undetectable		 2dtjA-3mtwA:
19.95
2dtjB-3mtwA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 11 GLY A 226
ASP A 294
THR A 215
GLY A 216
HIS A 252
 None
M3R  A 430 (-3.2A)
None
None
ZN  A   2 ( 3.2A)
 1.28A 2hmaA-3mtwA:
undetectable		 2hmaA-3mtwA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 12 GLY A 280
GLY A 258
LEU A 230
GLU A 261
VAL A 267
 None
 0.85A 2oxtB-3mtwA:
undetectable		 2oxtB-3mtwA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 7 HIS A  90
ASP A 268
THR A 269
HIS A  92
 ZN  A   1 ( 3.2A)
None
None
ZN  A   1 ( 3.2A)
 1.13A 3abmN-3mtwA:
undetectable
3abmP-3mtwA:
undetectable		 3abmN-3mtwA:
21.42
3abmP-3mtwA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 8 HIS A 171
GLY A 216
ASN A 223
PHE A 176
 M3R  A 430 (-3.9A)
None
None
None
 1.25A 3ccfA-3mtwA:
undetectable		 3ccfA-3mtwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 8 HIS A 171
GLY A 216
ASN A 223
PHE A 219
 M3R  A 430 (-3.9A)
None
None
M3R  A 430 (-4.3A)
 1.12A 3ccfA-3mtwA:
undetectable		 3ccfA-3mtwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 7 ASN A 297
TYR A 296
ASN A 308
ALA A 303
 M3R  A 430 (-3.7A)
None
None
None
 1.34A 3frqB-3mtwA:
undetectable		 3frqB-3mtwA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 6 VAL A  51
LEU A 413
ILE A  87
LEU A  37
 None
 0.85A 3kk6A-3mtwA:
undetectable		 3kk6A-3mtwA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 8 HIS A  90
ASP A 268
THR A 269
HIS A  92
 ZN  A   1 ( 3.2A)
None
None
ZN  A   1 ( 3.2A)
 1.17A 3x2qC-3mtwA:
undetectable
3x2qN-3mtwA:
undetectable
3x2qP-3mtwA:
undetectable		 3x2qC-3mtwA:
19.90
3x2qN-3mtwA:
21.42
3x2qP-3mtwA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 5 HIS A  90
HIS A 252
HIS A 272
ASP A 344
 ZN  A   1 ( 3.2A)
ZN  A   2 ( 3.2A)
ZN  A   2 ( 3.3A)
M3R  A 430 ( 2.4A)
 0.78A 4h9mA-3mtwA:
21.2		 4h9mA-3mtwA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 12 LEU A  83
LEU A  86
GLY A  85
ILE A  58
VAL A  53
 None
 1.16A 4ok1A-3mtwA:
undetectable		 4ok1A-3mtwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 12 GLY A 217
LEU A 275
THR A 301
ILE A 347
PHE A 219
 M3R  A 430 (-3.5A)
None
None
M3R  A 430 ( 4.9A)
M3R  A 430 (-4.3A)
 1.40A 4p6xE-3mtwA:
undetectable		 4p6xE-3mtwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 12 GLY A 217
LEU A 275
THR A 301
ILE A 347
PHE A 219
 M3R  A 430 (-3.5A)
None
None
M3R  A 430 ( 4.9A)
M3R  A 430 (-4.3A)
 1.41A 4p6xG-3mtwA:
undetectable		 4p6xG-3mtwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 8 ALA A 126
ASN A 133
ILE A 158
THR A 343
 None
 0.74A 4r20A-3mtwA:
undetectable		 4r20A-3mtwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 6 HIS A  90
HIS A  92
HIS A 252
HIS A 272
ASP A 344
 ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.2A)
ZN  A   2 ( 3.2A)
ZN  A   2 ( 3.3A)
M3R  A 430 ( 2.4A)
 0.66A 4ubpC-3mtwA:
19.3		 4ubpC-3mtwA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 12 GLY A 288
ASP A 277
ALA A 253
THR A 215
ALA A 262
 None
 1.11A 4uckB-3mtwA:
undetectable		 4uckB-3mtwA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 7 HIS A  90
ASP A 268
THR A 269
HIS A  92
 ZN  A   1 ( 3.2A)
None
None
ZN  A   1 ( 3.2A)
 1.15A 5b1aN-3mtwA:
undetectable
5b1aP-3mtwA:
undetectable		 5b1aN-3mtwA:
21.42
5b1aP-3mtwA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 5 THR A 301
GLY A 305
GLU A 312
ASP A 318
 None
None
None
M3R  A 430 (-3.8A)
 1.04A 5c0oH-3mtwA:
undetectable		 5c0oH-3mtwA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 12 GLU A 271
VAL A 340
GLY A 155
LEU A  93
HIS A  92
 None
None
None
None
ZN  A   1 ( 3.2A)
 1.23A 5esgA-3mtwA:
undetectable		 5esgA-3mtwA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 5 SER A 274
TYR A 363
SER A 373
ASP A 294
 None
SO4  A   5 (-4.6A)
None
M3R  A 430 (-3.2A)
 1.39A 5fhrA-3mtwA:
undetectable		 5fhrA-3mtwA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 12 ALA A 256
GLY A 258
GLY A 226
GLY A 280
LEU A 324
 SO4  A 431 (-3.5A)
None
None
None
None
 1.03A 5gwxA-3mtwA:
undetectable		 5gwxA-3mtwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 11 ILE A 371
ILE A 400
THR A 412
VAL A 361
MET A 360
 None
 1.36A 5jkwA-3mtwA:
undetectable		 5jkwA-3mtwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		5 / 10 MET A 420
PHE A 418
ILE A  61
LEU A  82
ALA A 401
 None
 1.49A 5oy0b-3mtwA:
undetectable		 5oy0b-3mtwA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 5 GLN A 372
THR A 375
THR A 412
LEU A  38
 None
 1.22A 6aphA-3mtwA:
3.9		 6aphA-3mtwA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 4 GLN A 372
THR A 375
THR A 412
LEU A  38
 None
 1.26A 6f3mA-3mtwA:
2.8		 6f3mA-3mtwA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 4 GLN A 372
THR A 375
THR A 412
LEU A  38
 None
 1.27A 6f3mC-3mtwA:
3.2		 6f3mC-3mtwA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 5 GLN A 372
THR A 375
THR A 412
LEU A  38
 None
 1.21A 6gbnB-3mtwA:
4.0		 6gbnB-3mtwA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672
(Caulobacter
vibrioides) 		4 / 6 HIS A  90
ASP A 268
THR A 269
HIS A  92
 ZN  A   1 ( 3.2A)
None
None
ZN  A   1 ( 3.2A)
 1.15A 6nmpA-3mtwA:
undetectable
6nmpC-3mtwA:
undetectable		 6nmpA-3mtwA:
21.42
6nmpC-3mtwA:
19.90