SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mtx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CBS_A_REAA200_1 (CELLULAR RETINOIC ACID BINDING PROTEIN TYPE II)	3mtx	PROTEIN MD-1 (Gallus gallus)	5 / 12	LEU A 104 ILE A 73 ALA A 78 VAL A 147 LEU A 123	None None PGT A 300 ( 3.9A) None None	1.08A	1cbsA-3mtxA: undetectable	1cbsA-3mtxA: 23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AVV_A_MK1A901_2 (POL POLYPROTEIN)	3mtx	PROTEIN MD-1 (Gallus gallus)	3 / 3	ASP A 151 VAL A 154 PRO A 129	None	0.66A	2avvA-3mtxA: undetectable	2avvA-3mtxA: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FR3_A_REAA300_1 (CELLULAR RETINOIC ACID BINDING PROTEIN 2)	3mtx	PROTEIN MD-1 (Gallus gallus)	5 / 12	LEU A 104 ILE A 73 ALA A 78 VAL A 147 LEU A 123	None None PGT A 300 ( 3.9A) None None	1.06A	2fr3A-3mtxA: undetectable	2fr3A-3mtxA: 23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKX_A_STRA601_2 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	3mtx	PROTEIN MD-1 (Gallus gallus)	4 / 6	LEU A 76 GLU A 94 VAL A 80 ALA A 137	None None None PGT A 300 ( 3.9A)	1.00A	4nkxA-3mtxA: undetectable	4nkxA-3mtxA: 15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RP8_C_ASCC501_0 (ASCORBATE-SPECIFIC PERMEASE IIC COMPONENT ULAA)	3mtx	PROTEIN MD-1 (Gallus gallus)	5 / 12	LEU A 123 ILE A 63 ILE A 135 ALA A 137 ILE A 35	None None PGT A 300 (-4.7A) PGT A 300 ( 3.9A) PGT A 300 ( 4.6A)	1.09A	4rp8C-3mtxA: undetectable	4rp8C-3mtxA: 17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AOX_F_ACTF1001_0 (ALU JO CONSENSUS RNA SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN)	3mtx	PROTEIN MD-1 (Gallus gallus)	3 / 3	TYR A 36 THR A 24 THR A 153	None	0.83A	5aoxE-3mtxA: undetectable	5aoxE-3mtxA: 18.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1CBS_A_REAA200_1","CELLULAR RETINOIC ACID BINDING PROTEIN TYPE II","3mtx","PROTEIN MD-1","Gallus gallus",5,"LEU A 104;ILE A  73;ALA A  78;VAL A 147;LEU A 123","None;None;PGT A 300 ( 3.9A);None;None","1.08A","1cbsA-3mtxA:undetectable","1cbsA-3mtxA:23.78"],["2AVV_A_MK1A901_2","POL POLYPROTEIN","3mtx","PROTEIN MD-1","Gallus gallus",3,"ASP A 151;VAL A 154;PRO A 129","None","0.66A","2avvA-3mtxA:undetectable","2avvA-3mtxA:21.48"],["2FR3_A_REAA300_1","CELLULAR RETINOIC ACID BINDING PROTEIN 2","3mtx","PROTEIN MD-1","Gallus gallus",5,"LEU A 104;ILE A  73;ALA A  78;VAL A 147;LEU A 123","None;None;PGT A 300 ( 3.9A);None;None","1.06A","2fr3A-3mtxA:undetectable","2fr3A-3mtxA:23.78"],["4NKX_A_STRA601_2","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","3mtx","PROTEIN MD-1","Gallus gallus",4,"LEU A  76;GLU A  94;VAL A  80;ALA A 137","None;None;None;PGT A 300 ( 3.9A)","1.00A","4nkxA-3mtxA:undetectable","4nkxA-3mtxA:15.66"],["4RP8_C_ASCC501_0","ASCORBATE-SPECIFIC PERMEASE IIC COMPONENT ULAA","3mtx","PROTEIN MD-1","Gallus gallus",5,"LEU A 123;ILE A  63;ILE A 135;ALA A 137;ILE A  35","None;None;PGT A 300 (-4.7A);PGT A 300 ( 3.9A);PGT A 300 ( 4.6A)","1.09A","4rp8C-3mtxA:undetectable","4rp8C-3mtxA:17.26"],["5AOX_F_ACTF1001_0","ALU JO CONSENSUS RNA;SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN","3mtx","PROTEIN MD-1","Gallus gallus",3,"TYR A  36;THR A  24;THR A 153","None","0.83A","5aoxE-3mtxA:undetectable","5aoxE-3mtxA:18.79"]]