SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mud'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 3mud DNA REPAIR PROTEIN
XRCC4,TROPOMYOSIN
ALPHA-1 CHAIN
(Gallus
gallus;
Homo
sapiens) 		5 / 11 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.90A 1t7jA-3mudA:
undetectable		 1t7jA-3mudA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3mud DNA REPAIR PROTEIN
XRCC4,TROPOMYOSIN
ALPHA-1 CHAIN
(Gallus
gallus;
Homo
sapiens) 		3 / 3 LEU A  36
LEU A  20
SER A   6
 None
 0.61A 1tlmA-3mudA:
undetectable		 1tlmA-3mudA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 3mud DNA REPAIR PROTEIN
XRCC4,TROPOMYOSIN
ALPHA-1 CHAIN
(Gallus
gallus;
Homo
sapiens) 		5 / 12 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.78A 3gguA-3mudA:
undetectable		 3gguA-3mudA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 3mud DNA REPAIR PROTEIN
XRCC4,TROPOMYOSIN
ALPHA-1 CHAIN
(Gallus
gallus;
Homo
sapiens) 		5 / 9 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.81A 3u7sA-3mudA:
undetectable		 3u7sA-3mudA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 3mud DNA REPAIR PROTEIN
XRCC4,TROPOMYOSIN
ALPHA-1 CHAIN
(Gallus
gallus;
Homo
sapiens) 		4 / 7 PHE A  95
PHE A 111
ALA A  73
LEU A  28
 None
 0.74A 4ejgC-3mudA:
undetectable		 4ejgC-3mudA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3mud DNA REPAIR PROTEIN
XRCC4,TROPOMYOSIN
ALPHA-1 CHAIN
(Gallus
gallus;
Homo
sapiens) 		4 / 7 SER A  53
ALA A  56
GLY A  64
VAL A  67
 None
 0.70A 5fpdA-3mudA:
undetectable		 5fpdA-3mudA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3mud DNA REPAIR PROTEIN
XRCC4,TROPOMYOSIN
ALPHA-1 CHAIN
(Gallus
gallus;
Homo
sapiens) 		4 / 7 SER A  53
ALA A  56
GLY A  64
VAL A  67
 None
 0.69A 5fpdB-3mudA:
undetectable		 5fpdB-3mudA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3mud DNA REPAIR PROTEIN
XRCC4,TROPOMYOSIN
ALPHA-1 CHAIN
(Gallus
gallus;
Homo
sapiens) 		5 / 12 LEU A  28
ILE A  34
LEU A 108
ALA A  73
TYR A  66
 None
 1.00A 6djzA-3mudA:
undetectable		 6djzA-3mudA:
20.94