SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		4 / 7 LEU A  41
THR A 231
ASN A  16
TYR A 220
 None
 1.05A 1afsA-3muxA:
5.6		 1afsA-3muxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		4 / 7 LEU A  41
THR A 231
ASN A  16
TYR A 220
 None
 1.05A 1afsB-3muxA:
5.7		 1afsB-3muxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		4 / 8 ARG A 104
VAL A 153
TRP A 113
GLU A 190
 None
 1.32A 1om5A-3muxA:
undetectable
1om5B-3muxA:
undetectable		 1om5A-3muxA:
19.61
1om5B-3muxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		4 / 6 PRO A 165
LYS A 167
ALA A 170
GLU A 174
 CL  A 252 (-4.7A)
None
None
None
 1.45A 1qhyA-3muxA:
undetectable		 1qhyA-3muxA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		4 / 7 ARG A 205
GLU A 172
ALA A 210
ALA A 179
 None
 1.06A 2ejfA-3muxA:
undetectable		 2ejfA-3muxA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		3 / 3 ASP A 235
ASP A 225
ASP A 196
 None
 0.78A 3douA-3muxA:
undetectable		 3douA-3muxA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		5 / 12 GLU A 190
GLY A 157
ALA A  85
GLY A  90
ASN A 106
 None
 1.44A 3jzjA-3muxA:
undetectable		 3jzjA-3muxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		4 / 6 ALA A  14
HIS A  92
HIS A 218
ASN A  16
 None
 1.12A 3nneG-3muxA:
undetectable		 3nneG-3muxA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		4 / 7 ILE A 223
LEU A 239
ALA A  31
ALA A  32
 None
 0.81A 3r9tB-3muxA:
1.6		 3r9tB-3muxA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		4 / 6 ARG A 205
GLN A 249
TYR A 250
LEU A 204
 None
 1.37A 3tgvB-3muxA:
undetectable		 3tgvB-3muxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		4 / 6 ARG A 205
GLN A 249
TYR A 250
LEU A 204
 None
 1.38A 3tgvD-3muxA:
undetectable		 3tgvD-3muxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		4 / 8 LEU A  18
VAL A 236
LEU A 239
ILE A 223
 None
 0.73A 4r38A-3muxA:
undetectable		 4r38A-3muxA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		5 / 9 THR A 192
LEU A  18
VAL A 236
LEU A 239
ILE A 223
 None
 0.91A 4r38C-3muxA:
undetectable		 4r38C-3muxA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		4 / 7 TRP A 113
GLU A 190
ARG A 104
VAL A 153
 None
 1.28A 4v3wA-3muxA:
undetectable
4v3wB-3muxA:
undetectable		 4v3wA-3muxA:
19.61
4v3wB-3muxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		4 / 6 PHE A  97
GLY A 132
THR A 131
ASN A  75
 None
 0.92A 5x24A-3muxA:
undetectable		 5x24A-3muxA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE
(Bacillus
anthracis) 		4 / 7 ARG A 104
VAL A 153
TRP A 113
GLU A 190
 None
 1.35A 6auuA-3muxA:
undetectable
6auuB-3muxA:
undetectable		 6auuA-3muxA:
16.33
6auuB-3muxA:
16.33