SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		5 / 8 ALA A 360
GLY A 270
ILE A 269
VAL A 356
ILE A 358
 None
 1.17A 1d4yB-3mveA:
undetectable		 1d4yB-3mveA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		4 / 4 LYS A 326
LEU A 334
ALA A 321
LEU A 317
 None
 1.49A 1f86B-3mveA:
undetectable		 1f86B-3mveA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		5 / 12 GLY A 347
ASN A 374
GLY A 275
ASN A 276
ILE A 294
 None
 1.10A 1q8jB-3mveA:
2.3		 1q8jB-3mveA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		3 / 3 PRO A 298
ASP A 373
ASP A 366
 EDO  A 417 ( 4.7A)
None
None
 0.81A 1sqfA-3mveA:
undetectable		 1sqfA-3mveA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		4 / 7 LEU A 255
MET A 278
VAL A 279
SER A 282
 None
 1.03A 1wrlA-3mveA:
undetectable
1wrlB-3mveA:
undetectable		 1wrlA-3mveA:
12.65
1wrlB-3mveA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		4 / 7 MET A 224
LEU A 402
VAL A 293
MET A 278
 None
 1.25A 2hrcA-3mveA:
2.5		 2hrcA-3mveA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		5 / 12 LEU A 409
LEU A 413
MET A 224
VAL A 198
LEU A 212
 None
 1.39A 2q7kA-3mveA:
undetectable		 2q7kA-3mveA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		5 / 12 GLY A 270
ALA A 277
LEU A 281
ALA A 405
VAL A 196
 None
 1.00A 2yvlA-3mveA:
undetectable		 2yvlA-3mveA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		5 / 12 ARG A  54
THR A 181
ASP A 203
LEU A 202
LEU A 247
 None
None
EDO  A 417 ( 4.7A)
EDO  A 417 (-4.1A)
None
 1.04A 3lcvB-3mveA:
undetectable		 3lcvB-3mveA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		5 / 12 ALA A 277
LEU A 281
SER A 282
PHE A 271
SER A 199
 None
 1.12A 3pfgA-3mveA:
undetectable		 3pfgA-3mveA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		5 / 10 ALA A 291
LEU A 409
LEU A 414
ILE A 222
ALA A 223
 None
 1.40A 3r9cA-3mveA:
undetectable		 3r9cA-3mveA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		3 / 3 GLN A  34
ASP A  83
GLN A  85
 None
 0.82A 4aztA-3mveA:
undetectable		 4aztA-3mveA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		3 / 3 TRP A 102
GLN A 148
THR A 103
 None
None
EDO  A 419 ( 2.8A)
 1.04A 4m2xA-3mveA:
undetectable		 4m2xA-3mveA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		3 / 3 PRO A 230
MET A 229
TYR A 244
 None
 1.04A 4qa0A-3mveA:
1.7		 4qa0A-3mveA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		4 / 8 THR A  32
LEU A  36
ILE A 331
LEU A  37
 None
 0.94A 5g48A-3mveA:
undetectable		 5g48A-3mveA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		3 / 3 ALA A  20
ASN A 144
LEU A 145
 None
None
EDO  A 419 ( 3.6A)
 0.45A 5i1nC-3mveA:
undetectable		 5i1nC-3mveA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		3 / 3 ALA A  20
ASN A 144
LEU A 145
 None
None
EDO  A 419 ( 3.6A)
 0.47A 5i1pD-3mveA:
undetectable		 5i1pD-3mveA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		5 / 12 ARG A 280
HIS A 139
PHE A 273
GLY A 201
GLY A 274
 None
None
None
EDO  A 417 (-3.3A)
None
 0.95A 5l6eA-3mveA:
undetectable		 5l6eA-3mveA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		5 / 12 TRP A 341
TYR A 316
ASP A 203
PRO A 138
LEU A 240
 None
EDO  A 417 (-4.6A)
EDO  A 417 ( 4.7A)
None
None
 1.48A 5l7iB-3mveA:
0.7		 5l7iB-3mveA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		3 / 3 LEU A 217
ILE A 406
TYR A 398
 None
 0.65A 5uunB-3mveA:
undetectable		 5uunB-3mveA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 3mve UPF0255 PROTEIN
VV1_0328
(Vibrio
vulnificus) 		5 / 12 ALA A 360
GLY A 270
ILE A 269
VAL A 356
ILE A 358
 None
 1.17A 6difA-3mveA:
undetectable		 6difA-3mveA:
10.47