SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mw8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI2_B_GA2B2_1
(THYMIDINE KINASE)		 3mw8 UROPORPHYRINOGEN-III
SYNTHASE
(Shewanella
amazonensis) 		5 / 12 ILE A  54
TYR A  78
MET A 134
ARG A 141
GLU A  96
 None
 1.46A 1ki2B-3mw8A:
1.4		 1ki2B-3mw8A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3mw8 UROPORPHYRINOGEN-III
SYNTHASE
(Shewanella
amazonensis) 		5 / 12 LEU A 158
CYH A 155
THR A 178
SER A 179
LEU A 189
 None
None
None
EDO  A 301 (-3.7A)
None
 1.13A 3okxA-3mw8A:
undetectable		 3okxA-3mw8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3mw8 UROPORPHYRINOGEN-III
SYNTHASE
(Shewanella
amazonensis) 		5 / 12 LEU A 158
CYH A 155
THR A 178
SER A 179
LEU A 189
 None
None
None
EDO  A 301 (-3.7A)
None
 1.14A 3okxB-3mw8A:
undetectable		 3okxB-3mw8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 3mw8 UROPORPHYRINOGEN-III
SYNTHASE
(Shewanella
amazonensis) 		4 / 8 PRO A 191
LEU A 186
VAL A 164
SER A 163
 None
 1.15A 4qknA-3mw8A:
undetectable		 4qknA-3mw8A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3mw8 UROPORPHYRINOGEN-III
SYNTHASE
(Shewanella
amazonensis) 		5 / 9 ALA A  95
ALA A  79
GLY A  92
ALA A  89
ASP A  86
 None
 1.17A 4qvnK-3mw8A:
undetectable
4qvnL-3mw8A:
undetectable		 4qvnK-3mw8A:
22.64
4qvnL-3mw8A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3mw8 UROPORPHYRINOGEN-III
SYNTHASE
(Shewanella
amazonensis) 		5 / 9 ALA A  95
ALA A  79
GLY A  92
ALA A  89
ASP A  86
 None
 1.17A 4qvnY-3mw8A:
undetectable
4qvnZ-3mw8A:
undetectable		 4qvnY-3mw8A:
22.64
4qvnZ-3mw8A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3mw8 UROPORPHYRINOGEN-III
SYNTHASE
(Shewanella
amazonensis) 		5 / 9 ALA A  95
ALA A  79
GLY A  92
ALA A  89
ASP A  86
 None
 1.19A 4qvqK-3mw8A:
undetectable
4qvqL-3mw8A:
undetectable		 4qvqK-3mw8A:
21.12
4qvqL-3mw8A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3mw8 UROPORPHYRINOGEN-III
SYNTHASE
(Shewanella
amazonensis) 		5 / 9 ALA A  95
ALA A  79
GLY A  92
ALA A  89
ASP A  86
 None
 1.19A 4qvqY-3mw8A:
undetectable
4qvqZ-3mw8A:
undetectable		 4qvqY-3mw8A:
21.12
4qvqZ-3mw8A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3mw8 UROPORPHYRINOGEN-III
SYNTHASE
(Shewanella
amazonensis) 		5 / 11 LEU A 109
LEU A 114
THR A  76
VAL A  80
ILE A  54
 None
 1.12A 4x20D-3mw8A:
undetectable		 4x20D-3mw8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 3mw8 UROPORPHYRINOGEN-III
SYNTHASE
(Shewanella
amazonensis) 		3 / 3 LYS A 120
ILE A 122
ILE A  54
 None
 0.62A 4y0qA-3mw8A:
undetectable		 4y0qA-3mw8A:
19.68