SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mwg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA
(Staphylococcus
aureus) 		5 / 11 ALA A 121
LEU A  59
LEU A 133
LEU A 108
SER A 112
 None
 1.08A 1h9zA-3mwgA:
undetectable		 1h9zA-3mwgA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA
(Staphylococcus
aureus) 		5 / 11 ALA A 121
LEU A  59
LEU A 133
LEU A 108
SER A 112
 None
 1.04A 1ha2A-3mwgA:
undetectable		 1ha2A-3mwgA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA
(Staphylococcus
aureus) 		5 / 12 GLN A  61
GLY A  62
THR A  58
ALA A  77
VAL A  78
 None
 0.99A 1jg4A-3mwgA:
undetectable		 1jg4A-3mwgA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA
(Staphylococcus
aureus) 		3 / 3 ASP A 297
ASP A 299
LYS A 322
 None
 0.89A 1lqtB-3mwgA:
2.5		 1lqtB-3mwgA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA
(Staphylococcus
aureus) 		3 / 3 ASP A 297
ASP A 299
LYS A 322
 None
 0.89A 1lquB-3mwgA:
undetectable		 1lquB-3mwgA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA
(Staphylococcus
aureus) 		4 / 7 ALA A 288
PHE A 256
ARG A 224
ASN A 251
 None
 1.38A 1t9wA-3mwgA:
undetectable		 1t9wA-3mwgA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA
(Staphylococcus
aureus) 		3 / 3 LYS A  84
ASP A 266
ASP A 203
 None
 1.13A 2br4A-3mwgA:
undetectable		 2br4A-3mwgA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA
(Staphylococcus
aureus) 		3 / 3 ARG A  55
THR A  97
VAL A  75
 None
 0.77A 2q64A-3mwgA:
undetectable		 2q64A-3mwgA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA
(Staphylococcus
aureus) 		3 / 3 ARG A  55
THR A  97
VAL A  75
 None
 1.01A 2qakA-3mwgA:
undetectable		 2qakA-3mwgA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA
(Staphylococcus
aureus) 		5 / 11 ALA A 288
ASP A 287
ASP A 253
ILE A 247
VAL A 257
 None
 1.03A 2qhcA-3mwgA:
undetectable		 2qhcA-3mwgA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA
(Staphylococcus
aureus) 		5 / 12 ALA A 288
ASP A 287
ASP A 253
ILE A 247
VAL A 257
 None
 0.99A 2qhcB-3mwgA:
undetectable		 2qhcB-3mwgA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA
(Staphylococcus
aureus) 		5 / 12 GLY A 221
LEU A 193
ILE A 216
ASP A 219
LEU A 319
 None
 0.96A 3cjtO-3mwgA:
5.6		 3cjtO-3mwgA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA
(Staphylococcus
aureus) 		5 / 11 LEU A  70
VAL A  66
LEU A 118
VAL A  57
THR A  58
 None
 1.35A 3tbgA-3mwgA:
undetectable		 3tbgA-3mwgA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA
(Staphylococcus
aureus) 		4 / 7 VAL A 197
ALA A 195
ASP A 318
LEU A 319
 None
 0.82A 4l9iA-3mwgA:
undetectable		 4l9iA-3mwgA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA
(Staphylococcus
aureus) 		5 / 12 ASN A 126
PRO A 106
ILE A 136
THR A  97
ILE A  99
 None
 1.20A 6j20A-3mwgA:
undetectable		 6j20A-3mwgA:
18.75