SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 8 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.71A 1hwiB-3mwtA:
undetectable		 1hwiB-3mwtA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 8 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.70A 1hwiD-3mwtA:
undetectable		 1hwiD-3mwtA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 8 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.70A 1hwiC-3mwtA:
undetectable		 1hwiC-3mwtA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		3 / 3 GLU A 391
HIS A 528
ASP A 466
 MN  A 680 (-3.9A)
None
None
 0.86A 1i9gA-3mwtA:
undetectable		 1i9gA-3mwtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 5 VAL A 124
GLY A 123
VAL A 161
TRP A 164
 None
 1.25A 1tkqB-3mwtA:
undetectable		 1tkqB-3mwtA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 5 MET A 388
ALA A 401
ILE A 400
ASP A 466
 None
 1.21A 1upfA-3mwtA:
undetectable		 1upfA-3mwtA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 5 MET A 388
ALA A 401
ILE A 400
ASP A 466
 None
 1.17A 1upfC-3mwtA:
undetectable		 1upfC-3mwtA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 SER A 322
TYR A 244
LEU A  70
GLY A  41
THR A 324
 None
 1.43A 2b8jB-3mwtA:
undetectable		 2b8jB-3mwtA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 6 LEU A 307
LEU A 279
PRO A 318
VAL A 270
 None
 0.80A 2dqyC-3mwtA:
undetectable		 2dqyC-3mwtA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		3 / 3 GLY A 316
ASP A 315
SER A 313
 None
 0.63A 2qhfA-3mwtA:
undetectable		 2qhfA-3mwtA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_2
(GLUCOCORTICOID
RECEPTOR)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 5 LEU A  70
ASN A  71
TRP A 164
MET A  54
 None
 1.38A 3h52D-3mwtA:
0.0		 3h52D-3mwtA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 4 ARG A  18
ASP A 260
GLY A 255
THR A 210
 None
 1.49A 3k4vB-3mwtA:
undetectable		 3k4vB-3mwtA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
 None
 1.26A 3lxiA-3mwtA:
undetectable		 3lxiA-3mwtA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 11 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
 None
 1.26A 3lxiB-3mwtA:
undetectable		 3lxiB-3mwtA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 6 ILE A 326
ILE A 241
GLY A 177
VAL A 113
 None
 0.89A 3n3iA-3mwtA:
undetectable		 3n3iA-3mwtA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		3 / 3 LYS A 488
ARG A 492
ASP A 466
 None
 1.30A 3o7wA-3mwtA:
undetectable		 3o7wA-3mwtA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 12 LEU A 470
ILE A 479
ILE A 390
ALA A 530
LEU A 380
 None
 1.50A 3vw1B-3mwtA:
undetectable		 3vw1B-3mwtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
 None
 1.34A 4c9nB-3mwtA:
undetectable		 4c9nB-3mwtA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 9 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
 None
 1.28A 4c9pA-3mwtA:
undetectable		 4c9pA-3mwtA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
 None
 1.26A 4c9pB-3mwtA:
undetectable		 4c9pB-3mwtA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 5 ARG A 323
ILE A 320
TRP A 317
GLY A 316
 None
 1.38A 4e7cC-3mwtA:
undetectable		 4e7cC-3mwtA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 6 LEU A 312
TYR A 308
ARG A 300
GLY A 177
 None
 1.04A 4l39A-3mwtA:
undetectable		 4l39A-3mwtA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 12 ILE A 450
VAL A 449
LEU A 373
LEU A 453
VAL A 553
 None
 1.16A 4m11D-3mwtA:
undetectable		 4m11D-3mwtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 7 ILE A 433
PHE A 423
LEU A 438
THR A 446
 None
 1.05A 4mmcA-3mwtA:
undetectable		 4mmcA-3mwtA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 6 ASP A  60
ASP A  63
ASN A  49
ARG A  52
 None
 1.20A 4ntxA-3mwtA:
undetectable
4ntxC-3mwtA:
undetectable		 4ntxA-3mwtA:
21.41
4ntxC-3mwtA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 6 ILE A 484
GLN A 462
ILE A 467
ASP A 466
 None
 1.21A 4w5tA-3mwtA:
undetectable		 4w5tA-3mwtA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 6 ILE A 484
GLN A 462
ILE A 467
ASP A 466
 None
 1.11A 4z4cA-3mwtA:
undetectable		 4z4cA-3mwtA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 6 ILE A 484
GLN A 462
ILE A 467
ASP A 466
 None
 1.21A 4z4dA-3mwtA:
undetectable		 4z4dA-3mwtA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 7 LEU A 554
LEU A 445
ALA A 448
ALA A 452
ALA A 376
 None
 1.34A 4z90F-3mwtA:
undetectable
4z90G-3mwtA:
undetectable
4z90H-3mwtA:
undetectable
4z90J-3mwtA:
undetectable		 4z90F-3mwtA:
20.44
4z90G-3mwtA:
20.44
4z90H-3mwtA:
20.44
4z90J-3mwtA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		3 / 3 ASP A  63
VAL A 166
LEU A 172
 None
 0.68A 5e5jB-3mwtA:
undetectable		 5e5jB-3mwtA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 ARG A 492
GLY A 392
HIS A 431
ALA A 530
ILE A 390
 None
 1.36A 5eeuD-3mwtA:
undetectable
5eeuE-3mwtA:
undetectable		 5eeuD-3mwtA:
9.37
5eeuE-3mwtA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 9 LEU A 279
LEU A 109
ILE A 326
ILE A 310
GLN A  84
 None
 1.39A 5ljdA-3mwtA:
undetectable		 5ljdA-3mwtA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 12 ARG A 455
LEU A 445
ILE A 411
ALA A 401
ILE A 467
 None
 1.18A 5vc0A-3mwtA:
undetectable		 5vc0A-3mwtA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 8 ILE A 459
LEU A 402
LEU A 531
ALA A 530
 None
 0.87A 5y7pE-3mwtA:
undetectable		 5y7pE-3mwtA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 6 ILE A 484
GLN A 462
ILE A 467
ASP A 466
 None
 1.20A 6cbdA-3mwtA:
undetectable		 6cbdA-3mwtA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 9 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.20A 6czmA-3mwtA:
undetectable
6czmB-3mwtA:
undetectable		 6czmA-3mwtA:
20.70
6czmB-3mwtA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 9 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.19A 6czmB-3mwtA:
undetectable
6czmC-3mwtA:
undetectable		 6czmB-3mwtA:
20.70
6czmC-3mwtA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 9 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.20A 6czmD-3mwtA:
undetectable
6czmE-3mwtA:
undetectable		 6czmD-3mwtA:
20.70
6czmE-3mwtA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 VAL A 199
VAL A 193
LEU A 202
LEU A 229
THR A 188
 None
 1.20A 6czmE-3mwtA:
undetectable
6czmF-3mwtA:
undetectable		 6czmE-3mwtA:
20.70
6czmF-3mwtA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 6 ARG A 476
ILE A 459
MET A 457
ASP A 478
 None
 1.48A 6dhbA-3mwtA:
undetectable		 6dhbA-3mwtA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3mwt NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 10 VAL A 449
ALA A 452
LEU A 445
LEU A 365
LEU A 554
 None
 0.96A 6f5uA-3mwtA:
undetectable
6f5uB-3mwtA:
undetectable		 6f5uA-3mwtA:
9.84
6f5uB-3mwtA:
8.60