SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 HIS W 911
ARG W 596
ILE W 549
HIS W 584
 None
 1.44A 1osvB-3mwyW:
0.0		 1osvB-3mwyW:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 HIS W 661
MET W 723
MET W 697
 None
 1.23A 2vj1A-3mwyW:
undetectable		 2vj1A-3mwyW:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 LEU W 606
LEU W 405
GLY W 404
GLY W 406
 None
None
AGS  W2000 (-3.1A)
AGS  W2000 (-3.3A)
 0.82A 3si7C-3mwyW:
0.0
3si7D-3mwyW:
undetectable		 3si7C-3mwyW:
16.90
3si7D-3mwyW:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 SER W 392
TYR W 354
SER W 352
SER W 351
PHE W 414
 None
 1.47A 3ugrA-3mwyW:
undetectable		 3ugrA-3mwyW:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR W 245
ASN W 244
ILE W 181
ARG W 277
 None
 1.37A 4o0oA-3mwyW:
undetectable		 4o0oA-3mwyW:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 GLU W 840
THR W 904
HIS W 806
LEU W 799
 None
 1.12A 4pgfA-3mwyW:
undetectable		 4pgfA-3mwyW:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 ASN W 459
GLU W 501
TYR W 494
ILE W 505
ILE W 429
 None
 1.47A 4xucA-3mwyW:
2.8		 4xucA-3mwyW:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 GLU W 318
LYS W 461
ASN W 315
 None
 1.10A 4y1dA-3mwyW:
undetectable
4y1dD-3mwyW:
undetectable		 4y1dA-3mwyW:
11.50
4y1dD-3mwyW:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 LEU W 673
GLY W 689
ASP W 729
ILE W 726
 None
 1.00A 5ik1A-3mwyW:
undetectable		 5ik1A-3mwyW:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ASN W 206
TYR W 211
CYH W 246
 None
 1.02A 5lsuB-3mwyW:
undetectable		 5lsuB-3mwyW:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 ASP W 742
SER W 753
ARG W 740
GLY W 728
LEU W 731
 None
 1.50A 5m50B-3mwyW:
undetectable		 5m50B-3mwyW:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 SER W 693
VAL W 616
SER W 821
PHE W 789
LEU W 727
 None
 1.34A 6a93B-3mwyW:
undetectable		 6a93B-3mwyW:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE W 765
THR W 782
PHE W 757
ILE W 716
VAL W 714
 None
 1.34A 6hcoA-3mwyW:
2.7
6hcoB-3mwyW:
2.6		 6hcoA-3mwyW:
22.28
6hcoB-3mwyW:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 TRP W 321
ILE W 291
ASP W 292
 None
 0.66A 6i0y7-3mwyW:
undetectable		 6i0y7-3mwyW:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 ASP W 464
ARG W 463
GLU W 501
ASP W 498
 None
 1.33A 6mn5D-3mwyW:
undetectable		 6mn5D-3mwyW:
7.39