SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mx3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		3 / 3 PHE A 220
LEU A 352
MET A 230
 None
 0.80A 1mx1D-3mx3A:
undetectable		 1mx1D-3mx3A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIV_A_T3A933_1
(ANDROGEN RECEPTOR)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		5 / 9 PRO A 148
GLY A 131
GLU A 129
TYR A 472
GLU A 476
 None
None
EPE  A 602 (-3.0A)
None
None
 1.37A 2pivA-3mx3A:
undetectable		 2pivA-3mx3A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		4 / 5 LEU A 505
ILE A 420
TRP A 360
TYR A 443
 None
 1.24A 2zlcA-3mx3A:
undetectable		 2zlcA-3mx3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		5 / 12 ILE A 315
PHE A 432
GLN A  78
ALA A 259
PHE A 327
 None
 1.34A 3apwB-3mx3A:
undetectable		 3apwB-3mx3A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		4 / 7 GLY A 179
PHE A 177
PHE A 117
PHE A 171
 None
 1.10A 3ko0D-3mx3A:
undetectable
3ko0E-3mx3A:
undetectable		 3ko0D-3mx3A:
11.04
3ko0E-3mx3A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		3 / 3 SER A  55
ASP A  61
ASP A 438
 None
MG  A 601 ( 2.4A)
None
 0.85A 3uj7A-3mx3A:
undetectable		 3uj7A-3mx3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		4 / 5 GLU A  62
PHE A 432
TYR A 249
HIS A 252
 MG  A 601 (-2.5A)
None
None
None
 1.42A 4a97J-3mx3A:
undetectable		 4a97J-3mx3A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		4 / 6 TRP A 470
ASN A 460
TYR A 440
LEU A  64
 EPE  A 602 ( 3.8A)
None
None
None
 1.14A 4f8yA-3mx3A:
undetectable
4f8yB-3mx3A:
undetectable		 4f8yA-3mx3A:
18.26
4f8yB-3mx3A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		3 / 3 SER A  55
ASP A  61
ASP A 438
 None
MG  A 601 ( 2.4A)
None
 0.81A 4mwzA-3mx3A:
undetectable		 4mwzA-3mx3A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		4 / 7 ASP A 438
ARG A 427
SER A 431
HIS A 435
 None
 1.26A 4o4dA-3mx3A:
undetectable		 4o4dA-3mx3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		4 / 6 PHE A 379
HIS A 376
ILE A 380
TYR A 283
 None
 1.39A 4o7gB-3mx3A:
4.5		 4o7gB-3mx3A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		5 / 9 ILE A 182
ASP A 180
LEU A 237
LEU A 114
PHE A 171
 None
 1.45A 4qopA-3mx3A:
undetectable		 4qopA-3mx3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		5 / 9 ILE A 182
ASP A 180
LEU A 237
LEU A 114
PHE A 171
 None
 1.45A 4qopB-3mx3A:
undetectable		 4qopB-3mx3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		5 / 9 ILE A 182
ASP A 180
LEU A 237
LEU A 114
PHE A 171
 None
 1.45A 4qopD-3mx3A:
0.2		 4qopD-3mx3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		5 / 12 GLN A 348
ALA A 193
ALA A 196
TYR A 121
TYR A 125
 None
 1.50A 5cxvA-3mx3A:
1.3		 5cxvA-3mx3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		4 / 8 LEU A 199
GLU A 347
LEU A 343
LEU A 164
 None
 1.16A 5dxeA-3mx3A:
undetectable		 5dxeA-3mx3A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		4 / 4 ILE A  49
GLY A  44
ILE A 118
LEU A  47
 None
 0.84A 5dzkl-3mx3A:
undetectable
5dzkz-3mx3A:
undetectable		 5dzkl-3mx3A:
18.13
5dzkz-3mx3A:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		4 / 7 GLU A 476
GLY A 141
TYR A 150
ALA A 138
 None
 0.98A 5e26A-3mx3A:
undetectable
5e26B-3mx3A:
undetectable		 5e26A-3mx3A:
22.13
5e26B-3mx3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		5 / 12 TYR A 125
PHE A 177
ILE A 187
GLY A 184
LEU A 237
 None
 1.38A 5esgA-3mx3A:
undetectable		 5esgA-3mx3A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		4 / 6 MET A 230
ALA A 196
LEU A 199
ILE A 223
 None
 0.84A 5mvmB-3mx3A:
2.6
5mvmC-3mx3A:
2.9		 5mvmB-3mx3A:
10.14
5mvmC-3mx3A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		5 / 12 ILE A 361
TYR A 368
GLY A 363
ILE A 223
ALA A 221
 None
 1.09A 5n0xA-3mx3A:
undetectable		 5n0xA-3mx3A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		3 / 3 LYS A 189
TRP A 190
SER A 188
 CL  A 603 ( 4.0A)
None
CL  A 603 (-3.2A)
 1.36A 5nwwA-3mx3A:
undetectable		 5nwwA-3mx3A:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		4 / 5 ASP A 442
ARG A 427
LEU A 161
MET A 157
 None
 1.42A 5tuiB-3mx3A:
undetectable		 5tuiB-3mx3A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		4 / 5 ASP A 442
ARG A 427
LEU A 161
MET A 157
 None
 1.47A 5tuiB-3mx3A:
undetectable		 5tuiB-3mx3A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3mx3 SUSD HOMOLOG
(Bacteroides
fragilis) 		4 / 6 THR A 446
ARG A 445
PRO A 449
ILE A 420
 None
 1.16A 6ef6A-3mx3A:
undetectable		 6ef6A-3mx3A:
19.36