SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY5_A_ACTA600_0
(RIBONUCLEASE A)		 3mx8 RIBONUCLEASE
PANCREATIC, LINKER,
RIBONUCLEASE
PANCREATIC
(Bos
taurus) 		4 / 4 HIS A  12
VAL A  43
ASN A  44
THR A  45
 SO4  A 256 ( 4.0A)
None
SO4  A 253 (-3.8A)
SO4  A 253 (-4.2A)
 0.41A 1dy5A-3mx8A:
24.4		 1dy5A-3mx8A:
49.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY5_A_ACTA600_0
(RIBONUCLEASE A)		 3mx8 RIBONUCLEASE
PANCREATIC, LINKER,
RIBONUCLEASE
PANCREATIC
(Bos
taurus) 		4 / 4 HIS A 140
VAL A 171
ASN A 172
THR A 173
 SO4  A 255 ( 4.0A)
None
CL  A 258 (-4.6A)
CL  A 258 (-4.7A)
 0.29A 1dy5A-3mx8A:
24.4		 1dy5A-3mx8A:
49.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N3Z_A_ADNA126_1
(RIBONUCLEASE,
SEMINAL)		 3mx8 RIBONUCLEASE
PANCREATIC, LINKER,
RIBONUCLEASE
PANCREATIC
(Bos
taurus) 		6 / 9 ALA A   4
LYS A   7
ASN A  67
ASN A  71
ALA A 109
VAL A 118
 None
 0.38A 1n3zA-3mx8A:
23.5		 1n3zA-3mx8A:
42.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N3Z_A_ADNA126_1
(RIBONUCLEASE,
SEMINAL)		 3mx8 RIBONUCLEASE
PANCREATIC, LINKER,
RIBONUCLEASE
PANCREATIC
(Bos
taurus) 		6 / 9 ALA A 132
ASN A 195
GLN A 197
ASN A 199
ALA A 237
VAL A 246
 SO4  A 257 (-3.4A)
None
None
None
None
None
 0.87A 1n3zA-3mx8A:
23.5		 1n3zA-3mx8A:
42.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N3Z_A_ADNA126_1
(RIBONUCLEASE,
SEMINAL)		 3mx8 RIBONUCLEASE
PANCREATIC, LINKER,
RIBONUCLEASE
PANCREATIC
(Bos
taurus) 		6 / 9 ALA A 132
LYS A 135
ASN A 195
ASN A 199
ALA A 237
VAL A 246
 SO4  A 257 (-3.4A)
None
None
None
None
None
 0.39A 1n3zA-3mx8A:
23.5		 1n3zA-3mx8A:
42.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3mx8 RIBONUCLEASE
PANCREATIC, LINKER,
RIBONUCLEASE
PANCREATIC
(Bos
taurus) 		4 / 6 ASP A  83
ALA A 102
LYS A 104
THR A  82
 None
 1.49A 4w5rA-3mx8A:
undetectable		 4w5rA-3mx8A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3mx8 RIBONUCLEASE
PANCREATIC, LINKER,
RIBONUCLEASE
PANCREATIC
(Bos
taurus) 		3 / 3 HIS A 176
GLU A 177
ASN A 231
 None
 1.01A 5wbvA-3mx8A:
undetectable		 5wbvA-3mx8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3mx8 RIBONUCLEASE
PANCREATIC, LINKER,
RIBONUCLEASE
PANCREATIC
(Bos
taurus) 		3 / 3 HIS A 176
GLU A 177
ASN A 231
 None
 1.01A 5wbvB-3mx8A:
undetectable		 5wbvB-3mx8A:
19.22