SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 3mxl NITROSOSYNTHASE
(Micromonospora
sp.
ATCC
39149) 		5 / 12 ALA A  85
ASP A  84
GLY A 207
PRO A 341
ILE A 259
 None
 0.89A 1c6yB-3mxlA:
undetectable		 1c6yB-3mxlA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3mxl NITROSOSYNTHASE
(Micromonospora
sp.
ATCC
39149) 		4 / 8 ALA A 133
PHE A 170
VAL A 172
VAL A 190
 None
 0.85A 1epbB-3mxlA:
undetectable		 1epbB-3mxlA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 3mxl NITROSOSYNTHASE
(Micromonospora
sp.
ATCC
39149) 		5 / 12 VAL A 336
LEU A 253
PHE A 329
GLN A 330
ALA A 383
 None
 1.48A 2jj8C-3mxlA:
undetectable		 2jj8C-3mxlA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3mxl NITROSOSYNTHASE
(Micromonospora
sp.
ATCC
39149) 		3 / 3 LEU A 362
PRO A 361
LEU A 365
 None
 0.45A 2po7B-3mxlA:
undetectable		 2po7B-3mxlA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3mxl NITROSOSYNTHASE
(Micromonospora
sp.
ATCC
39149) 		3 / 3 LEU A 362
PRO A 361
LEU A 365
 None
 0.44A 3hcrA-3mxlA:
undetectable		 3hcrA-3mxlA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3mxl NITROSOSYNTHASE
(Micromonospora
sp.
ATCC
39149) 		5 / 12 ALA A 194
PHE A 218
SER A 155
LEU A 144
VAL A 223
 None
 1.39A 4kyaH-3mxlA:
undetectable		 4kyaH-3mxlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3mxl NITROSOSYNTHASE
(Micromonospora
sp.
ATCC
39149) 		4 / 7 GLN A 330
THR A 246
THR A  75
MET A  78
 None
 1.10A 4mbsA-3mxlA:
1.7		 4mbsA-3mxlA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3mxl NITROSOSYNTHASE
(Micromonospora
sp.
ATCC
39149) 		4 / 6 ILE A 255
VAL A  93
THR A 213
ARG A 364
 None
 1.13A 4xe5A-3mxlA:
undetectable		 4xe5A-3mxlA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 3mxl NITROSOSYNTHASE
(Micromonospora
sp.
ATCC
39149) 		4 / 7 ASP A  84
THR A  87
PRO A  41
THR A  39
 None
 1.30A 5b6iA-3mxlA:
undetectable		 5b6iA-3mxlA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3mxl NITROSOSYNTHASE
(Micromonospora
sp.
ATCC
39149) 		5 / 12 VAL A  17
ASP A  18
LEU A  99
ALA A  76
GLY A  52
 None
 1.14A 5syeB-3mxlA:
undetectable		 5syeB-3mxlA:
21.02