SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 3mzk PROTEIN TRANSPORT
PROTEIN SEC16
(Saccharomyces
cerevisiae) 		4 / 8 MET B1134
LEU B1128
LYS B1155
LEU B1151
 None
 0.94A 1ya4A-3mzkB:
undetectable		 1ya4A-3mzkB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 3mzk PROTEIN TRANSPORT
PROTEIN SEC16
(Saccharomyces
cerevisiae) 		3 / 3 ASN B1144
LEU B1140
HIS B1145
 None
 0.84A 2q6fB-3mzkB:
undetectable		 2q6fB-3mzkB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3mzk PROTEIN TRANSPORT
PROTEIN SEC16
(Saccharomyces
cerevisiae) 		4 / 8 THR B1268
ASP B1297
ASP B1295
GLU B1301
 None
 0.95A 2zw9A-3mzkB:
undetectable		 2zw9A-3mzkB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 3mzk PROTEIN TRANSPORT
PROTEIN SEC16
(Saccharomyces
cerevisiae) 		5 / 12 THR B1080
ILE B1098
LEU B1084
VAL B1256
LEU B1260
 None
 0.86A 3a51C-3mzkB:
undetectable		 3a51C-3mzkB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3mzk PROTEIN TRANSPORT
PROTEIN SEC16
(Saccharomyces
cerevisiae) 		4 / 6 LEU B1361
SER B1364
LEU B1368
LEU B1382
 None
 0.78A 3f33A-3mzkB:
undetectable		 3f33A-3mzkB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 3mzk PROTEIN TRANSPORT
PROTEIN SEC16
(Saccharomyces
cerevisiae) 		5 / 10 LEU B1378
GLY B1354
SER B1364
VAL B1365
LEU B1382
 None
 0.81A 3ogpA-3mzkB:
undetectable		 3ogpA-3mzkB:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 3mzk PROTEIN TRANSPORT
PROTEIN SEC16
(Saccharomyces
cerevisiae) 		3 / 3 TYR B1318
MET B1293
LEU B1257
 None
 0.98A 3vw1D-3mzkB:
undetectable		 3vw1D-3mzkB:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3mzk PROTEIN TRANSPORT
PROTEIN SEC16
(Saccharomyces
cerevisiae) 		5 / 12 TYR B1318
ILE B1321
ILE B1098
LEU B1239
VAL B1256
 None
 1.10A 3w68B-3mzkB:
undetectable		 3w68B-3mzkB:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3mzk PROTEIN TRANSPORT
PROTEIN SEC16
(Saccharomyces
cerevisiae) 		3 / 3 TYR B1006
THR B1030
GLU B1026
 None
 0.66A 4df3A-3mzkB:
undetectable		 4df3A-3mzkB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3mzk PROTEIN TRANSPORT
PROTEIN SEC16
(Saccharomyces
cerevisiae) 		3 / 3 TYR B1006
THR B1030
GLU B1026
 None
 0.66A 4df3B-3mzkB:
undetectable		 4df3B-3mzkB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 3mzk PROTEIN TRANSPORT
PROTEIN SEC16
(Saccharomyces
cerevisiae) 		5 / 8 SER B1302
THR B1273
SER B1277
THR B1308
SER B1311
 None
 1.46A 5l4eA-3mzkB:
2.7
5l4eB-3mzkB:
2.6
5l4eC-3mzkB:
2.6
5l4eD-3mzkB:
2.7
5l4eE-3mzkB:
2.6		 5l4eA-3mzkB:
22.82
5l4eB-3mzkB:
22.82
5l4eC-3mzkB:
22.82
5l4eD-3mzkB:
22.82
5l4eE-3mzkB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 3mzk PROTEIN TRANSPORT
PROTEIN SEC16
(Saccharomyces
cerevisiae) 		5 / 8 THR B1308
SER B1311
SER B1302
THR B1273
SER B1277
 None
 1.46A 5l4eA-3mzkB:
2.7
5l4eB-3mzkB:
2.6
5l4eC-3mzkB:
2.6
5l4eD-3mzkB:
2.7
5l4eE-3mzkB:
2.6		 5l4eA-3mzkB:
22.82
5l4eB-3mzkB:
22.82
5l4eC-3mzkB:
22.82
5l4eD-3mzkB:
22.82
5l4eE-3mzkB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 3mzk PROTEIN TRANSPORT
PROTEIN SEC16
(Saccharomyces
cerevisiae) 		5 / 9 THR B1308
SER B1311
SER B1302
THR B1273
SER B1277
 None
 1.49A 5muoA-3mzkB:
2.7
5muoB-3mzkB:
2.6
5muoC-3mzkB:
undetectable
5muoD-3mzkB:
undetectable
5muoE-3mzkB:
2.6		 5muoA-3mzkB:
13.61
5muoB-3mzkB:
13.61
5muoC-3mzkB:
13.61
5muoD-3mzkB:
13.61
5muoE-3mzkB:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 3mzk PROTEIN TRANSPORT
PROTEIN SEC16
(Saccharomyces
cerevisiae) 		4 / 5 GLY B1050
LEU B1049
SER B1323
TYR B1324
 None
 1.20A 6ji6A-3mzkB:
undetectable		 6ji6A-3mzkB:
20.49