SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mzl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3mzl PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		5 / 11 ALA B 526
LEU B 531
ALA B 543
LEU B 551
SER B 554
 None
 1.28A 1tz8A-3mzlB:
undetectable
1tz8B-3mzlB:
undetectable		 1tz8A-3mzlB:
16.86
1tz8B-3mzlB:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3mzl PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		5 / 11 ALA B 543
LEU B 551
SER B 554
ALA B 526
LEU B 531
 None
 1.22A 1tz8A-3mzlB:
undetectable
1tz8B-3mzlB:
undetectable		 1tz8A-3mzlB:
16.86
1tz8B-3mzlB:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 3mzl PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		3 / 3 PHE B 684
VAL B 644
TRP B 648
 None
 0.91A 2cc8A-3mzlB:
undetectable		 2cc8A-3mzlB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 3mzl PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		3 / 3 PHE B 684
VAL B 644
TRP B 648
 None
 0.89A 2ccbA-3mzlB:
undetectable		 2ccbA-3mzlB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 3mzl PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		3 / 3 PHE B 684
VAL B 644
TRP B 648
 None
 0.89A 2vx9A-3mzlB:
undetectable		 2vx9A-3mzlB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 3mzl PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae) 		5 / 9 ARG B 571
LEU B 588
ALA B 599
LEU B 615
ILE B 596
 None
 1.44A 3wsjA-3mzlB:
undetectable		 3wsjA-3mzlB:
18.40