SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 6 GLY A 145
ALA A 229
TYR A 146
GLU A 256
 None
ACT  A 452 ( 4.0A)
None
None
 0.99A 1dmaB-3mznA:
undetectable		 1dmaB-3mznA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 7 LEU A  21
LEU A  23
GLY A 204
LEU A 207
 None
 0.93A 1gtiB-3mznA:
undetectable		 1gtiB-3mznA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 ILE A 366
ASP A 168
ILE A 380
ALA A 143
ARG A 174
 None
None
GOL  A 451 (-4.5A)
None
None
 1.22A 1kijB-3mznA:
undetectable		 1kijB-3mznA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 VAL A 242
GLU A 262
GLY A 260
ASN A 233
GLN A 293
 None
 1.34A 1vidA-3mznA:
undetectable		 1vidA-3mznA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 5 ASP A 239
LEU A 238
LYS A 237
ARG A 277
 None
 1.06A 2gj5A-3mznA:
undetectable		 2gj5A-3mznA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 6 LEU A 158
TRP A 430
MET A 179
LEU A  21
 None
 1.22A 2oz7A-3mznA:
undetectable		 2oz7A-3mznA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 7 LEU A 294
ASP A 290
TRP A 313
THR A 284
 None
 1.35A 3dzgB-3mznA:
undetectable		 3dzgB-3mznA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 9 GLN A 371
ASP A 341
ILE A 342
VAL A  35
VAL A  13
 None
 1.47A 3fi0L-3mznA:
undetectable		 3fi0L-3mznA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 ASP A 231
PHE A 148
SER A  24
 None
SO4  A 450 (-4.7A)
None
 0.98A 3i5uB-3mznA:
undetectable		 3i5uB-3mznA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 HIS A 335
SER A 343
ASN A 338
 None
None
SO4  A 450 ( 4.8A)
 0.89A 3s8pB-3mznA:
undetectable		 3s8pB-3mznA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 5 ASN A 285
LEU A 307
SER A 336
LEU A 144
 None
None
None
ACT  A 452 ( 4.2A)
 1.29A 4n09C-3mznA:
3.4		 4n09C-3mznA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 5 GLN A 416
SER A  53
ASP A 100
ASP A 290
 None
 1.38A 4qtuB-3mznA:
undetectable		 4qtuB-3mznA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 6 LEU A 202
LEU A 187
VAL A 184
PHE A 148
 None
None
None
SO4  A 450 (-4.7A)
 1.13A 4uswA-3mznA:
undetectable		 4uswA-3mznA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 PHE A 116
GLY A 124
LEU A 123
ALA A 128
VAL A  75
 None
 1.04A 4wnwB-3mznA:
undetectable		 4wnwB-3mznA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 11 ASN A 285
THR A 270
GLY A 267
ARG A  96
THR A 289
 None
 1.25A 4xt7A-3mznA:
undetectable		 4xt7A-3mznA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 5 ARG A  81
ARG A  71
GLY A  69
GLU A  41
 None
 1.24A 4z3oA-3mznA:
undetectable
4z3oB-3mznA:
undetectable		 4z3oA-3mznA:
21.57
4z3oB-3mznA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 5 PHE A 223
ASP A 199
PHE A 197
PHE A 200
 None
ACT  A 452 (-3.6A)
None
None
 1.15A 5a1rA-3mznA:
undetectable		 5a1rA-3mznA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 4 LEU A 202
ARG A 217
ILE A 216
ILE A 248
 None
 1.24A 5dzk2-3mznA:
undetectable
5dzkM-3mznA:
1.6
5dzkN-3mznA:
0.8		 5dzk2-3mznA:
8.70
5dzkM-3mznA:
18.75
5dzkN-3mznA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 4 ILE A 216
ILE A 248
ARG A 217
LEU A 202
 None
 1.34A 5dzkh-3mznA:
1.0
5dzkn-3mznA:
1.0
5dzkv-3mznA:
undetectable		 5dzkh-3mznA:
18.75
5dzkn-3mznA:
18.75
5dzkv-3mznA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 VAL A 242
GLU A 262
GLY A 260
ASN A 233
GLN A 293
 None
 1.34A 5fhrA-3mznA:
undetectable		 5fhrA-3mznA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 TRP A 236
GLU A 212
ASP A 231
 None
 0.60A 5gqbA-3mznA:
6.2		 5gqbA-3mznA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 6 VAL A  13
HIS A 406
LEU A 402
CYH A  34
 None
 1.13A 5hrqB-3mznA:
undetectable
5hrqI-3mznA:
undetectable
5hrqJ-3mznA:
undetectable		 5hrqB-3mznA:
6.43
5hrqI-3mznA:
5.88
5hrqJ-3mznA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 ALA A 183
ASN A 186
LEU A 187
 None
 0.44A 5i1nC-3mznA:
undetectable		 5i1nC-3mznA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 ALA A 183
ASN A 186
LEU A 187
 None
 0.37A 5i1nB-3mznA:
undetectable		 5i1nB-3mznA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 ALA A 183
ASN A 186
LEU A 187
 None
 0.33A 5i1oC-3mznA:
undetectable		 5i1oC-3mznA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 ALA A 183
ASN A 186
LEU A 187
 None
 0.43A 5i1oA-3mznA:
undetectable		 5i1oA-3mznA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 ALA A 183
ASN A 186
LEU A 187
 None
 0.35A 5i1pA-3mznA:
undetectable		 5i1pA-3mznA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		3 / 3 ALA A 183
ASN A 186
LEU A 187
 None
 0.37A 5i1pD-3mznA:
undetectable		 5i1pD-3mznA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 4 ASN A 285
LEU A 307
SER A 336
LEU A 144
 None
None
None
ACT  A 452 ( 4.2A)
 1.28A 5kb5A-3mznA:
2.3		 5kb5A-3mznA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 LEU A  20
GLY A  15
PRO A  29
HIS A  27
GLU A 404
 None
None
None
SO4  A 450 (-4.1A)
None
 1.28A 5x6yA-3mznA:
undetectable		 5x6yA-3mznA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 7 HIS A  27
ASP A 231
GLY A 204
ASN A  22
 SO4  A 450 (-4.1A)
None
None
SO4  A 450 (-3.2A)
 1.12A 5x7pA-3mznA:
undetectable		 5x7pA-3mznA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 5 HIS A  27
ASP A 231
GLY A 204
ASN A  22
 SO4  A 450 (-4.1A)
None
None
SO4  A 450 (-3.2A)
 1.11A 5x7pB-3mznA:
undetectable		 5x7pB-3mznA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 ALA A  82
SER A 343
HIS A 311
LEU A 115
ALA A 114
 None
 1.18A 6djzC-3mznA:
undetectable		 6djzC-3mznA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		5 / 12 LEU A  60
SER A 343
HIS A 311
LEU A 115
ALA A 114
 None
 1.09A 6djzC-3mznA:
undetectable		 6djzC-3mznA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3mzn GLUCARATE
DEHYDRATASE
(Chromohalobacter
salexigens) 		4 / 6 TRP A 170
LEU A 149
ASP A  17
GLN A 371
 None
 1.45A 6djzC-3mznA:
undetectable		 6djzC-3mznA:
19.06