SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		5 / 12 GLY A 178
LEU A 132
LEU A 133
PRO A 135
VAL A 136
 None
 1.04A 1gseA-3mzsA:
undetectable		 1gseA-3mzsA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		5 / 12 GLY A 178
LEU A 132
LEU A 133
PRO A 135
VAL A 136
 None
 1.03A 1gseB-3mzsA:
undetectable		 1gseB-3mzsA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		5 / 12 ILE A 235
ALA A 286
ILE A  85
HIS A  92
PHE A 236
 None
HC9  A 501 ( 4.1A)
None
None
None
 1.38A 1y0xX-3mzsA:
1.9		 1y0xX-3mzsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		5 / 11 SER A 137
LEU A 435
ILE A 438
ARG A 321
LEU A 164
 None
 1.31A 3a9eB-3mzsA:
2.0		 3a9eB-3mzsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		5 / 10 PHE A 203
GLY A 288
GLY A 287
GLU A 432
ILE A 428
 HC9  A 501 (-4.6A)
HEM  A 500 (-3.6A)
HEM  A 500 (-3.4A)
None
None
 1.24A 3fw1A-3mzsA:
undetectable		 3fw1A-3mzsA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		5 / 12 SER A  60
ILE A  85
ILE A  36
HIS A  40
TYR A  51
 None
 1.25A 3g8iA-3mzsA:
undetectable		 3g8iA-3mzsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 5 SER A 106
GLY A 107
TRP A 109
ASP A 112
 None
None
HEM  A 500 (-4.4A)
None
 0.99A 3w9tB-3mzsA:
undetectable		 3w9tB-3mzsA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 5 SER A 106
GLY A 107
TRP A 109
ASP A 112
 None
None
HEM  A 500 (-4.4A)
None
 0.99A 3w9tC-3mzsA:
undetectable		 3w9tC-3mzsA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 5 SER A 106
GLY A 107
TRP A 109
ASP A 112
 None
None
HEM  A 500 (-4.4A)
None
 0.99A 3w9tD-3mzsA:
undetectable		 3w9tD-3mzsA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 6 ILE A 196
ILE A  85
TRP A  88
MET A 202
 None
None
HC9  A 501 (-4.7A)
None
 1.29A 3welA-3mzsA:
undetectable		 3welA-3mzsA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 6 ILE A 196
ILE A  85
TRP A 232
MET A 202
 None
 1.50A 3weoA-3mzsA:
undetectable		 3weoA-3mzsA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		3 / 3 GLU A 344
ASP A 397
ASP A 394
 None
 0.53A 4gc9A-3mzsA:
undetectable		 4gc9A-3mzsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 4 LEU A 338
LEU A 402
GLN A 310
GLU A 315
 None
 1.12A 4i41A-3mzsA:
undetectable		 4i41A-3mzsA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		3 / 3 ARG A 180
GLU A 179
PHE A 246
 None
 0.88A 4kszA-3mzsA:
0.1		 4kszA-3mzsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 4 ILE A  50
VAL A 378
VAL A  61
ARG A  52
 None
 1.27A 4m6tA-3mzsA:
undetectable		 4m6tA-3mzsA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 5 PHE A 436
HIS A 299
LEU A 313
PRO A 398
 None
 1.25A 4o8zA-3mzsA:
undetectable		 4o8zA-3mzsA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		5 / 12 LEU A 296
LEU A 300
SER A 306
LEU A 437
PRO A 398
 None
 1.12A 5hnwB-3mzsA:
undetectable		 5hnwB-3mzsA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		5 / 12 LEU A 300
SER A 306
LEU A 437
THR A 434
PRO A 398
 None
 0.87A 5hnwB-3mzsA:
undetectable		 5hnwB-3mzsA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		5 / 12 LEU A 300
SER A 306
LEU A 437
THR A 434
PRO A 398
 None
 0.98A 5hnxB-3mzsA:
undetectable		 5hnxB-3mzsA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		5 / 12 LEU A 296
LEU A 300
SER A 306
LEU A 437
PRO A 398
 None
 1.12A 5hnyB-3mzsA:
undetectable		 5hnyB-3mzsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		5 / 12 LEU A 300
SER A 306
LEU A 437
THR A 434
PRO A 398
 None
 0.88A 5hnyB-3mzsA:
undetectable		 5hnyB-3mzsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		3 / 3 ARG A 347
HIS A 349
ARG A 385
 None
 1.06A 5iaoC-3mzsA:
undetectable		 5iaoC-3mzsA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		3 / 3 ARG A 347
HIS A 349
ARG A 385
 None
 1.04A 5iaoF-3mzsA:
undetectable		 5iaoF-3mzsA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		3 / 3 GLU A  12
ARG A   8
TYR A 368
 None
 0.65A 5trqB-3mzsA:
undetectable		 5trqB-3mzsA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		5 / 12 ILE A 468
PHE A 472
PHE A 436
GLY A 158
PHE A 167
 None
 1.41A 5v5zA-3mzsA:
29.5		 5v5zA-3mzsA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 8 SER A 206
PHE A 458
VAL A 199
ILE A 351
 None
HC9  A 501 (-4.8A)
None
HEM  A 500 ( 4.4A)
 1.06A 5vkqB-3mzsA:
2.0
5vkqC-3mzsA:
undetectable		 5vkqB-3mzsA:
14.66
5vkqC-3mzsA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 5 LEU A 300
THR A 434
PRO A 398
ARG A 347
 None
 1.28A 6ew0B-3mzsA:
undetectable		 6ew0B-3mzsA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 5 LEU A 300
THR A 434
PRO A 398
ARG A 400
 None
 0.96A 6ew0B-3mzsA:
undetectable		 6ew0B-3mzsA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 5 LEU A 300
THR A 434
PRO A 398
ARG A 347
 None
 1.28A 6ew0D-3mzsA:
undetectable		 6ew0D-3mzsA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 5 LEU A 300
THR A 434
PRO A 398
ARG A 400
 None
 0.96A 6ew0D-3mzsA:
undetectable		 6ew0D-3mzsA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 5 LEU A 300
THR A 434
PRO A 398
ARG A 400
 None
 0.96A 6ew0F-3mzsA:
undetectable		 6ew0F-3mzsA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 6 LEU A 300
THR A 434
PRO A 398
ARG A 400
 None
 0.96A 6ew0G-3mzsA:
undetectable		 6ew0G-3mzsA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 5 LEU A 300
THR A 434
PRO A 398
ARG A 347
 None
 1.28A 6ew0H-3mzsA:
undetectable		 6ew0H-3mzsA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 5 LEU A 300
THR A 434
PRO A 398
ARG A 400
 None
 0.96A 6ew0H-3mzsA:
undetectable		 6ew0H-3mzsA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 5 LEU A 300
THR A 434
PRO A 398
ARG A 347
 None
 1.28A 6ew0I-3mzsA:
undetectable		 6ew0I-3mzsA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME
(Bos
taurus) 		4 / 5 LEU A 300
THR A 434
PRO A 398
ARG A 400
 None
 0.95A 6ew0I-3mzsA:
undetectable		 6ew0I-3mzsA:
12.72