SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3mzy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 3mzy RNA POLYMERASE
SIGMA-H FACTOR
(Fusobacterium
nucleatum) 		4 / 8 PHE A 145
SER A 146
ILE A 185
ILE A 188
 None
 0.76A 1sbrA-3mzyA:
undetectable		 1sbrA-3mzyA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 3mzy RNA POLYMERASE
SIGMA-H FACTOR
(Fusobacterium
nucleatum) 		4 / 7 PHE A 145
SER A 146
ILE A 185
ILE A 188
 None
 0.79A 1sbrB-3mzyA:
undetectable		 1sbrB-3mzyA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3mzy RNA POLYMERASE
SIGMA-H FACTOR
(Fusobacterium
nucleatum) 		4 / 5 ILE A 162
ILE A 196
ILE A 188
LEU A 135
 None
 0.81A 1zgyA-3mzyA:
undetectable		 1zgyA-3mzyA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3mzy RNA POLYMERASE
SIGMA-H FACTOR
(Fusobacterium
nucleatum) 		4 / 7 LEU A  55
ALA A  58
PHE A  72
PHE A  69
 None
 1.04A 2vcvL-3mzyA:
undetectable		 2vcvL-3mzyA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 3mzy RNA POLYMERASE
SIGMA-H FACTOR
(Fusobacterium
nucleatum) 		4 / 8 ILE A  59
LEU A 158
VAL A 157
LEU A 161
 None
 0.75A 2w98B-3mzyA:
undetectable		 2w98B-3mzyA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 3mzy RNA POLYMERASE
SIGMA-H FACTOR
(Fusobacterium
nucleatum) 		5 / 11 ILE A 188
PHE A 150
SER A 151
PHE A 142
VAL A  48
 None
 1.38A 3a9eB-3mzyA:
undetectable		 3a9eB-3mzyA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3mzy RNA POLYMERASE
SIGMA-H FACTOR
(Fusobacterium
nucleatum) 		4 / 8 ILE A 139
SER A 192
LEU A 158
LEU A 161
 None
 0.91A 4xtaB-3mzyA:
undetectable		 4xtaB-3mzyA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3mzy RNA POLYMERASE
SIGMA-H FACTOR
(Fusobacterium
nucleatum) 		4 / 4 ASN A 183
ILE A  59
TYR A  62
PHE A  74
 None
 1.17A 5igvA-3mzyA:
undetectable		 5igvA-3mzyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 3mzy RNA POLYMERASE
SIGMA-H FACTOR
(Fusobacterium
nucleatum) 		5 / 12 ILE A 188
PHE A 150
SER A 151
PHE A 142
VAL A  48
 None
 1.37A 5uanB-3mzyA:
undetectable		 5uanB-3mzyA:
15.86