SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n00'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3n00 REV-ERBA-ALPHA
NUCLEAR RECEPTOR
COREPRESSOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG A 448
ILE B2058
ALA A 446
HIS B2054
 None
 0.97A 1wmqA-3n00A:
undetectable		 1wmqA-3n00A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3n00 REV-ERBA-ALPHA
NUCLEAR RECEPTOR
COREPRESSOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG A 448
ILE B2058
ALA A 446
HIS B2054
 None
 0.97A 1wmqB-3n00A:
undetectable		 1wmqB-3n00A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3n00 REV-ERBA-ALPHA
NUCLEAR RECEPTOR
COREPRESSOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG A 448
ILE B2058
ALA A 446
HIS B2054
 None
 0.96A 1wpuA-3n00A:
undetectable		 1wpuA-3n00A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3n00 REV-ERBA-ALPHA
NUCLEAR RECEPTOR
COREPRESSOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG A 448
ILE B2058
ALA A 446
HIS B2054
 None
 0.97A 1wpuB-3n00A:
undetectable		 1wpuB-3n00A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3n00 REV-ERBA-ALPHA
NUCLEAR RECEPTOR
COREPRESSOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG A 448
ILE B2058
ALA A 446
HIS B2054
 None
 0.95A 1wrqA-3n00A:
undetectable		 1wrqA-3n00A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3n00 REV-ERBA-ALPHA
NUCLEAR RECEPTOR
COREPRESSOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG A 448
ILE B2058
ALA A 446
HIS B2054
 None
 0.95A 1wrqB-3n00A:
undetectable		 1wrqB-3n00A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3n00 REV-ERBA-ALPHA
NUCLEAR RECEPTOR
COREPRESSOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 PHE B2063
ARG B2065
ALA A 454
ARG A 461
 None
 1.09A 2e5dA-3n00B:
undetectable
2e5dB-3n00B:
undetectable		 2e5dA-3n00B:
3.72
2e5dB-3n00B:
3.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3n00 REV-ERBA-ALPHA
(Homo
sapiens) 		5 / 12 LEU A 592
LEU A 527
PHE A 585
LEU A 570
ALA A 293
 None
 1.07A 3vw7A-3n00A:
undetectable		 3vw7A-3n00A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3n00 NUCLEAR RECEPTOR
COREPRESSOR 1
REV-ERBA-ALPHA
(Homo
sapiens) 		4 / 8 PHE B2063
ARG B2065
ALA A 454
ARG A 461
 None
 1.17A 4lv9A-3n00B:
undetectable
4lv9B-3n00B:
undetectable		 4lv9A-3n00B:
3.72
4lv9B-3n00B:
3.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 3n00 REV-ERBA-ALPHA
NUCLEAR RECEPTOR
COREPRESSOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 5 HIS B2054
ILE B2058
SER A 440
ALA A 446
 None
 1.14A 5msdA-3n00B:
undetectable		 5msdA-3n00B:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3n00 REV-ERBA-ALPHA
(Homo
sapiens) 		5 / 9 LEU A 545
THR A 541
ILE A 299
PHE A 300
ILE A 457
 None
 1.08A 6ebpA-3n00A:
undetectable		 6ebpA-3n00A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3n00 REV-ERBA-ALPHA
(Homo
sapiens) 		5 / 10 LEU A 545
THR A 541
ILE A 299
PHE A 300
ILE A 457
 None
 1.05A 6ebpB-3n00A:
3.3		 6ebpB-3n00A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3n00 REV-ERBA-ALPHA
(Homo
sapiens) 		5 / 10 LEU A 545
THR A 541
ILE A 299
PHE A 300
ILE A 457
 None
 1.08A 6ebpD-3n00A:
undetectable		 6ebpD-3n00A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3n00 REV-ERBA-ALPHA
(Homo
sapiens) 		5 / 11 LEU A 545
THR A 541
ILE A 299
PHE A 300
ILE A 457
 None
 1.06A 6ebzA-3n00A:
undetectable		 6ebzA-3n00A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3n00 REV-ERBA-ALPHA
(Homo
sapiens) 		5 / 11 LEU A 545
THR A 541
ILE A 299
PHE A 300
ILE A 457
 None
 1.07A 6ebzB-3n00A:
3.2		 6ebzB-3n00A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3n00 REV-ERBA-ALPHA
(Homo
sapiens) 		5 / 11 LEU A 545
THR A 541
ILE A 299
PHE A 300
ILE A 457
 None
 1.06A 6ebzC-3n00A:
undetectable		 6ebzC-3n00A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3n00 REV-ERBA-ALPHA
(Homo
sapiens) 		5 / 11 LEU A 545
THR A 541
ILE A 299
PHE A 300
ILE A 457
 None
 1.05A 6ebzD-3n00A:
undetectable		 6ebzD-3n00A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3n00 REV-ERBA-ALPHA
(Homo
sapiens) 		5 / 11 LEU A 545
THR A 541
ILE A 299
PHE A 300
ILE A 457
 None
 1.02A 6gp2A-3n00A:
undetectable		 6gp2A-3n00A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3n00 REV-ERBA-ALPHA
(Homo
sapiens) 		5 / 11 LEU A 545
THR A 541
ILE A 299
PHE A 300
ILE A 457
 None
 1.02A 6gp2B-3n00A:
3.2		 6gp2B-3n00A:
14.89