SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 11 ALA A 214
LEU A   5
ILE A 156
PRO A  84
THR A 213
 None
 1.01A 1dyrA-3n05A:
undetectable		 1dyrA-3n05A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		4 / 7 GLN A 246
ASP A 228
LEU A 216
SER A 248
 None
 1.26A 1ig3A-3n05A:
2.0
1ig3B-3n05A:
2.4		 1ig3A-3n05A:
18.97
1ig3B-3n05A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		3 / 3 ARG A 278
GLY A 178
ASP A 155
 None
 0.58A 1kf6A-3n05A:
3.4
1kf6B-3n05A:
undetectable		 1kf6A-3n05A:
23.25
1kf6B-3n05A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 10 GLU A  62
SER A  64
ALA A  21
THR A  47
ASP A  91
 None
None
None
None
SO4  A 590 (-3.8A)
 1.50A 1m4dA-3n05A:
0.0		 1m4dA-3n05A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		4 / 8 TYR A 354
LEU A 380
GLY A 379
GLY A 349
 None
 0.84A 1rukH-3n05A:
undetectable
1rukL-3n05A:
undetectable		 1rukH-3n05A:
17.25
1rukL-3n05A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 12 GLY A 221
ILE A 562
LEU A 311
VAL A 313
ALA A 310
 None
 1.04A 1v2xA-3n05A:
undetectable		 1v2xA-3n05A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		3 / 3 ASP A 523
ARG A 571
ASP A 521
 None
 0.87A 1vptA-3n05A:
undetectable		 1vptA-3n05A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		4 / 7 THR A 213
LEU A 199
VAL A 202
ASP A 235
 None
 0.89A 2cppA-3n05A:
undetectable		 2cppA-3n05A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		4 / 7 GLU A  94
PRO A 142
ARG A 108
GLY A 105
 None
 1.30A 2hs1B-3n05A:
undetectable		 2hs1B-3n05A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 12 ILE A 343
ALA A 342
TRP A 469
ALA A 338
ILE A 562
 None
 1.08A 3e00A-3n05A:
undetectable		 3e00A-3n05A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 11 GLY A 425
ASN A 381
ASN A 352
SER A 326
LEU A 328
 None
 1.38A 3ndvA-3n05A:
undetectable
3ndvB-3n05A:
undetectable		 3ndvA-3n05A:
22.71
3ndvB-3n05A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 11 GLY A 425
ASN A 381
ASN A 352
SER A 326
LEU A 328
 None
 1.37A 3ndvA-3n05A:
undetectable
3ndvB-3n05A:
undetectable		 3ndvA-3n05A:
22.71
3ndvB-3n05A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 11 GLY A 425
ASN A 381
ASN A 352
SER A 326
LEU A 328
 None
 1.38A 3ndvC-3n05A:
undetectable
3ndvD-3n05A:
undetectable		 3ndvC-3n05A:
22.71
3ndvD-3n05A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 11 GLY A 425
ASN A 381
ASN A 352
SER A 326
LEU A 328
 None
 1.39A 3ndvC-3n05A:
undetectable
3ndvD-3n05A:
undetectable		 3ndvC-3n05A:
22.71
3ndvD-3n05A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 9 GLY A 432
ILE A 329
GLY A 334
ILE A 335
ILE A 343
 None
 0.87A 3s53A-3n05A:
undetectable		 3s53A-3n05A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 10 ALA A   6
LEU A 181
LEU A  38
LEU A  86
ILE A 156
 None
 1.10A 3wdmB-3n05A:
undetectable		 3wdmB-3n05A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 9 ALA A   6
LEU A 181
LEU A  38
LEU A  86
ILE A 156
 None
 1.08A 3wdmC-3n05A:
undetectable		 3wdmC-3n05A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		3 / 3 ARG A 203
ASP A 230
GLN A 246
 None
 0.93A 4azsA-3n05A:
3.9		 4azsA-3n05A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 11 ILE A 232
LEU A 181
ASP A 235
GLY A 238
VAL A 241
 None
 1.26A 4fogC-3n05A:
undetectable		 4fogC-3n05A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		4 / 8 ASN A 186
ALA A 187
PRO A 189
TRP A 165
 None
 0.80A 4jjkA-3n05A:
4.5		 4jjkA-3n05A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 11 GLY A 220
ALA A 187
GLY A 229
ILE A 156
LEU A 151
 None
 1.07A 4kt0A-3n05A:
undetectable
4kt0J-3n05A:
undetectable		 4kt0A-3n05A:
20.93
4kt0J-3n05A:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		4 / 8 THR A 213
LEU A 199
VAL A 202
ASP A 235
 None
 0.91A 4l4aA-3n05A:
undetectable		 4l4aA-3n05A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 12 ALA A 174
GLY A 180
LEU A   1
LEU A 258
ALA A 177
 None
 1.10A 4lg1A-3n05A:
undetectable		 4lg1A-3n05A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 12 ALA A 174
GLY A 180
LEU A   1
LEU A 258
ALA A 177
 None
 1.14A 4lg1B-3n05A:
undetectable		 4lg1B-3n05A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		4 / 4 ILE A 562
VAL A 312
VAL A 307
ARG A 192
 None
 1.38A 4m6tA-3n05A:
undetectable		 4m6tA-3n05A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		4 / 6 PRO A  84
ILE A 156
VAL A 185
ARG A 278
 None
 1.10A 4xe5A-3n05A:
undetectable		 4xe5A-3n05A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 12 GLY A 432
ILE A 329
GLY A 334
ILE A 335
ILE A 343
 None
 0.85A 5e5jB-3n05A:
undetectable		 5e5jB-3n05A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 12 GLY A 432
ILE A 329
GLY A 334
ILE A 335
ILE A 343
 None
 0.82A 5e5kB-3n05A:
undetectable		 5e5kB-3n05A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		4 / 6 LEU A 183
LEU A 258
LEU A   3
LEU A 254
 None
 0.97A 5gs4A-3n05A:
undetectable		 5gs4A-3n05A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		4 / 8 HIS A 152
LEU A   1
GLY A 153
SER A 282
 None
 0.97A 5m8rC-3n05A:
undetectable		 5m8rC-3n05A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 9 PRO A  84
LEU A 151
VAL A 113
LEU A  86
ASP A 277
 None
 1.29A 5tixA-3n05A:
1.8		 5tixA-3n05A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 10 PRO A  84
LEU A 151
VAL A 113
LEU A  86
ASP A 277
 None
 1.30A 5tixB-3n05A:
undetectable		 5tixB-3n05A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 12 ALA A 371
GLY A 333
SER A 367
PHE A 382
ARG A 413
 None
 1.13A 5w7pA-3n05A:
3.2		 5w7pA-3n05A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		5 / 11 ARG A 376
GLY A 333
ASP A 370
ALA A 338
ILE A 483
 None
 1.22A 5yk2A-3n05A:
undetectable		 5yk2A-3n05A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		3 / 3 MET A 146
ASP A 271
ARG A 205
 None
 1.00A 5z6jA-3n05A:
undetectable		 5z6jA-3n05A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		3 / 3 MET A 146
ASP A 271
ARG A 205
 None
 1.15A 5z6kA-3n05A:
undetectable		 5z6kA-3n05A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		4 / 6 PHE A 382
ARG A 376
ARG A 377
LEU A 380
 None
 0.96A 6b89B-3n05A:
undetectable		 6b89B-3n05A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		4 / 5 THR A  28
LEU A 183
VAL A 149
LEU A   3
 None
 0.93A 6bqgA-3n05A:
undetectable		 6bqgA-3n05A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Streptomyces
avermitilis) 		4 / 6 PRO A 245
ILE A 219
GLY A 250
GLU A 249
 None
 1.03A 6gqiA-3n05A:
2.7		 6gqiA-3n05A:
21.76