SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN
(Bos
taurus) 		4 / 8 VAL A  88
TYR A 103
MET A  73
VAL A 158
 None
 0.99A 1fduB-3n0aA:
undetectable		 1fduB-3n0aA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN
(Bos
taurus) 		4 / 8 THR A 184
PRO A 185
GLY A 186
ARG A 190
 None
 0.86A 1oc3A-3n0aA:
undetectable		 1oc3A-3n0aA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN
(Bos
taurus) 		5 / 12 ILE A 199
ILE A  71
THR A  64
VAL A 105
HIS A 160
 None
 0.91A 2qo5A-3n0aA:
undetectable		 2qo5A-3n0aA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN
(Bos
taurus) 		4 / 4 ILE A 283
ARG A 275
ILE A 281
THR A 263
 None
CL  A 402 (-3.0A)
None
None
 1.21A 3ia4C-3n0aA:
undetectable		 3ia4C-3n0aA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN
(Bos
taurus) 		5 / 10 ILE A 170
ALA A 132
ILE A 327
THR A 331
ILE A 261
 None
 0.92A 3prsA-3n0aA:
undetectable		 3prsA-3n0aA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN
(Bos
taurus) 		3 / 3 LYS A 195
LEU A 191
ALA A 194
 None
 0.72A 4iizA-3n0aA:
2.7		 4iizA-3n0aA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN
(Bos
taurus) 		3 / 3 ARG A  98
HIS A  99
SER A  97
 None
 1.01A 4mjwA-3n0aA:
undetectable
4mjwB-3n0aA:
undetectable		 4mjwA-3n0aA:
20.43
4mjwB-3n0aA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN
(Bos
taurus) 		3 / 3 SER A  97
ARG A  98
HIS A  99
 None
 1.01A 4mjwA-3n0aA:
undetectable
4mjwB-3n0aA:
undetectable		 4mjwA-3n0aA:
20.43
4mjwB-3n0aA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN
(Bos
taurus) 		3 / 3 MET A 212
ASP A 292
PHE A 322
 None
 0.78A 4xeyA-3n0aA:
undetectable		 4xeyA-3n0aA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN
(Bos
taurus) 		3 / 3 MET A 212
ASP A 292
PHE A 322
 None
 0.74A 4xeyB-3n0aA:
undetectable		 4xeyB-3n0aA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN
(Bos
taurus) 		5 / 12 LEU A 228
ILE A 327
GLY A 325
VAL A 254
VAL A 295
 None
 1.05A 6emuB-3n0aA:
2.1		 6emuB-3n0aA:
18.98