SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n0c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3n0c THYMIDYLATE SYNTHASE
THYX
(Thermotoga
maritima) 		4 / 6 VAL A  14
VAL A 162
ILE A 193
ARG A 157
 None
 1.12A 1iepA-3n0cA:
undetectable		 1iepA-3n0cA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3n0c THYMIDYLATE SYNTHASE
THYX
(Thermotoga
maritima) 		4 / 8 ASP A  20
PHE A  57
ARG A  42
ALA A  23
 None
 1.13A 1rqpA-3n0cA:
undetectable		 1rqpA-3n0cA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3n0c THYMIDYLATE SYNTHASE
THYX
(Thermotoga
maritima) 		5 / 12 LEU A 171
PHE A 170
LEU A 167
VAL A  16
VAL A  11
 None
 0.91A 2po5A-3n0cA:
undetectable		 2po5A-3n0cA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3n0c THYMIDYLATE SYNTHASE
THYX
(Thermotoga
maritima) 		5 / 11 LEU A 171
PHE A 170
LEU A 167
VAL A  16
VAL A  11
 None
 0.91A 2po5B-3n0cA:
undetectable		 2po5B-3n0cA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 3n0c THYMIDYLATE SYNTHASE
THYX
(Thermotoga
maritima) 		3 / 3 TYR A  99
TYR A 186
ILE A   5
 None
 0.70A 3eteA-3n0cA:
undetectable
3eteB-3n0cA:
undetectable		 3eteA-3n0cA:
20.24
3eteB-3n0cA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 3n0c THYMIDYLATE SYNTHASE
THYX
(Thermotoga
maritima) 		4 / 8 ALA A 175
LEU A 215
ASP A 213
TYR A 210
 None
 0.95A 3qj7A-3n0cA:
undetectable
3qj7D-3n0cA:
undetectable		 3qj7A-3n0cA:
22.83
3qj7D-3n0cA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3n0c THYMIDYLATE SYNTHASE
THYX
(Thermotoga
maritima) 		4 / 4 ASP A  20
LEU A  21
ARG A  28
THR A 201
 None
 1.49A 4kjjA-3n0cA:
undetectable		 4kjjA-3n0cA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 3n0c THYMIDYLATE SYNTHASE
THYX
(Thermotoga
maritima) 		3 / 3 VAL A  11
TYR A 186
ALA A 189
 None
 0.53A 4ybnA-3n0cA:
undetectable		 4ybnA-3n0cA:
21.57