SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 10 LEU A 141
ARG A 147
PHE A  73
PHE A  72
ILE A  71
 None
 1.25A 1g5yC-3n0tA:
undetectable		 1g5yC-3n0tA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 11 TRP A 420
TYR A 163
GLY A 161
VAL A 192
PRO A 188
 OPY  A1001 (-3.5A)
None
None
None
OPY  A1001 (-4.3A)
 1.33A 1i9jH-3n0tA:
undetectable
1i9jL-3n0tA:
undetectable		 1i9jH-3n0tA:
18.70
1i9jL-3n0tA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 11 GLY A 423
GLY A 196
GLN A 200
GLY A 402
GLY A 401
 None
 1.03A 1mxgA-3n0tA:
undetectable		 1mxgA-3n0tA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 12 ALA A 310
ALA A 262
ILE A 303
PHE A 261
LEU A 249
 None
 1.10A 2nyrA-3n0tA:
undetectable		 2nyrA-3n0tA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 12 THR A 304
ALA A 310
ALA A 262
ILE A 227
PHE A 261
 None
 1.08A 2nyrA-3n0tA:
undetectable		 2nyrA-3n0tA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 6 TYR A 110
TRP A 347
TYR A 163
ILE A 355
 None
OPY  A1001 (-4.1A)
None
None
 1.49A 2pgzD-3n0tA:
undetectable
2pgzE-3n0tA:
undetectable		 2pgzD-3n0tA:
20.25
2pgzE-3n0tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 7 VAL A 205
ALA A 270
PHE A 359
PRO A 335
 None
 1.08A 2q6oA-3n0tA:
undetectable		 2q6oA-3n0tA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 5 LEU A 141
ASP A 148
LEU A 171
HIS A  42
 None
 1.31A 2qxsB-3n0tA:
undetectable		 2qxsB-3n0tA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 7 PRO A 455
VAL A 458
ARG A 462
PRO A 275
 None
 0.96A 2v2gA-3n0tA:
undetectable
2v2gB-3n0tA:
undetectable		 2v2gA-3n0tA:
19.57
2v2gB-3n0tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 7 PRO A 275
PRO A 455
VAL A 458
ARG A 462
 None
 0.93A 2v2gA-3n0tA:
undetectable
2v2gB-3n0tA:
undetectable		 2v2gA-3n0tA:
19.57
2v2gB-3n0tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 7 PRO A 455
VAL A 458
ARG A 462
PRO A 275
 None
 0.96A 2v2gC-3n0tA:
undetectable
2v2gD-3n0tA:
undetectable		 2v2gC-3n0tA:
19.57
2v2gD-3n0tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 7 PRO A 275
PRO A 455
VAL A 458
ARG A 462
 None
 0.93A 2v2gC-3n0tA:
undetectable
2v2gD-3n0tA:
undetectable		 2v2gC-3n0tA:
19.57
2v2gD-3n0tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 8 PRO A 455
VAL A 458
ARG A 462
PRO A 275
 None
 0.96A 2v32A-3n0tA:
undetectable
2v32B-3n0tA:
undetectable		 2v32A-3n0tA:
19.57
2v32B-3n0tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 8 PRO A 275
PRO A 455
VAL A 458
ARG A 462
 None
 0.93A 2v32A-3n0tA:
undetectable
2v32B-3n0tA:
undetectable		 2v32A-3n0tA:
19.57
2v32B-3n0tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 8 PRO A 455
VAL A 458
ARG A 462
PRO A 275
 None
 0.97A 2v32C-3n0tA:
undetectable
2v32D-3n0tA:
undetectable		 2v32C-3n0tA:
19.57
2v32D-3n0tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 8 PRO A 275
PRO A 455
VAL A 458
ARG A 462
 None
 0.97A 2v32C-3n0tA:
undetectable
2v32D-3n0tA:
undetectable		 2v32C-3n0tA:
19.57
2v32D-3n0tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 8 PRO A 275
PRO A 455
VAL A 458
ARG A 462
 None
 0.98A 2v41C-3n0tA:
undetectable
2v41D-3n0tA:
undetectable		 2v41C-3n0tA:
19.57
2v41D-3n0tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 7 PRO A 455
VAL A 458
ARG A 462
PRO A 275
 None
 1.00A 2v41E-3n0tA:
undetectable
2v41F-3n0tA:
undetectable		 2v41E-3n0tA:
19.57
2v41F-3n0tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 7 PRO A 275
PRO A 455
VAL A 458
ARG A 462
 None
 1.03A 2v41E-3n0tA:
undetectable
2v41F-3n0tA:
undetectable		 2v41E-3n0tA:
19.57
2v41F-3n0tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 8 PRO A 455
VAL A 458
ARG A 462
PRO A 275
 None
 1.00A 2v41G-3n0tA:
undetectable
2v41H-3n0tA:
undetectable		 2v41G-3n0tA:
19.57
2v41H-3n0tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 8 PRO A 275
PRO A 455
VAL A 458
ARG A 462
 None
 0.89A 2v41G-3n0tA:
undetectable
2v41H-3n0tA:
undetectable		 2v41G-3n0tA:
19.57
2v41H-3n0tA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 11 LEU A 135
ALA A 169
ALA A 187
TYR A 163
PHE A 399
 None
 1.27A 3bszF-3n0tA:
undetectable		 3bszF-3n0tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 11 LEU A 135
ALA A 169
PHE A 412
ALA A 184
TYR A 163
 None
 1.42A 3bszF-3n0tA:
undetectable		 3bszF-3n0tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 4 PHE A 266
TYR A 314
ARG A 448
LEU A 417
 None
 1.47A 3sueA-3n0tA:
undetectable		 3sueA-3n0tA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 12 GLY A 415
ASP A 446
GLY A 424
PHE A 412
ALA A 184
 None
 1.28A 3sueD-3n0tA:
undetectable		 3sueD-3n0tA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 7 GLY A  99
ALA A 100
TRP A  64
ALA A 154
 None
 0.59A 3ur0B-3n0tA:
undetectable		 3ur0B-3n0tA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 9 GLY A 441
GLY A 440
SER A 186
GLY A 415
TYR A 274
 None
 1.27A 3ztvA-3n0tA:
undetectable		 3ztvA-3n0tA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 12 ALA A 185
PHE A 412
MET A 173
LEU A 404
VAL A 189
 None
 1.13A 4eckB-3n0tA:
undetectable		 4eckB-3n0tA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 12 GLY A  69
GLY A  99
ILE A  71
ALA A 151
ARG A 146
 None
 1.13A 4kicA-3n0tA:
undetectable		 4kicA-3n0tA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 12 GLY A  69
GLY A  99
ILE A  71
ALA A 151
ARG A 146
 None
 1.12A 4kicB-3n0tA:
undetectable		 4kicB-3n0tA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 12 PRO A  70
GLY A 181
PHE A  72
ARG A  98
LEU A  94
 None
 1.36A 4kotA-3n0tA:
undetectable		 4kotA-3n0tA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 12 GLY A  76
GLY A 164
LEU A 171
VAL A  81
ALA A 134
 None
 0.92A 5kpcA-3n0tA:
undetectable		 5kpcA-3n0tA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 12 GLY A  76
GLY A 164
ASP A  80
VAL A  81
ALA A 134
 None
 1.05A 5kpcB-3n0tA:
undetectable		 5kpcB-3n0tA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 10 VAL A 239
ILE A 227
GLY A 234
ALA A 235
PHE A 231
 None
 1.17A 5mxbA-3n0tA:
undetectable		 5mxbA-3n0tA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		4 / 5 ALA A 134
HIS A 107
GLN A 350
TYR A 163
 None
 1.41A 5uizA-3n0tA:
undetectable		 5uizA-3n0tA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens) 		5 / 11 VAL A 189
ALA A 191
LEU A 404
ALA A 193
LEU A 395
 None
 1.45A 6dk1B-3n0tA:
undetectable		 6dk1B-3n0tA:
19.57