SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		5 / 11 GLY A  64
GLU A  74
HIS A  69
LEU A  70
PRO A  71
 None
 1.43A 1mjqA-3n0uA:
undetectable
1mjqB-3n0uA:
undetectable		 1mjqA-3n0uA:
21.33
1mjqB-3n0uA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		5 / 10 GLY A  64
GLU A  74
HIS A  69
LEU A  70
PRO A  71
 None
 1.43A 1mjqG-3n0uA:
undetectable
1mjqH-3n0uA:
undetectable		 1mjqG-3n0uA:
21.33
1mjqH-3n0uA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		5 / 12 ALA A  91
GLN A  88
ARG A  80
LEU A  79
ALA A  76
 None
 1.07A 1xdkA-3n0uA:
undetectable		 1xdkA-3n0uA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		5 / 11 GLY A  56
SER A  52
ASN A 137
THR A  48
HIS A 133
 None
 1.16A 2hmaA-3n0uA:
undetectable		 2hmaA-3n0uA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		5 / 12 ASN A 137
HIS A 133
GLN A  60
PHE A  67
THR A  48
 None
 1.27A 3bl1A-3n0uA:
undetectable		 3bl1A-3n0uA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		5 / 12 LEU A 197
LEU A   8
GLU A  24
VAL A 182
LEU A 179
 None
 0.94A 4y0sA-3n0uA:
undetectable		 4y0sA-3n0uA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		4 / 7 LEU A  79
ALA A  59
LEU A  47
LEU A  75
 None
 0.64A 4z90F-3n0uA:
undetectable
4z90G-3n0uA:
undetectable
4z90H-3n0uA:
undetectable
4z90J-3n0uA:
undetectable		 4z90F-3n0uA:
20.24
4z90G-3n0uA:
20.24
4z90H-3n0uA:
20.24
4z90J-3n0uA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		4 / 5 THR A  48
GLU A  41
THR A 138
LEU A 119
 None
 1.14A 5hm8A-3n0uA:
undetectable		 5hm8A-3n0uA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		4 / 5 THR A  48
GLU A  41
THR A 138
LEU A 119
 None
 1.15A 5hm8B-3n0uA:
undetectable		 5hm8B-3n0uA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		4 / 5 THR A  48
GLU A  41
THR A 138
LEU A 119
 None
 1.15A 5hm8C-3n0uA:
undetectable		 5hm8C-3n0uA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		4 / 5 THR A  48
GLU A  41
THR A 138
LEU A 119
 None
 1.15A 5hm8D-3n0uA:
undetectable		 5hm8D-3n0uA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		4 / 5 THR A  48
GLU A  41
THR A 138
LEU A 119
 None
 1.14A 5hm8E-3n0uA:
undetectable		 5hm8E-3n0uA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		4 / 5 THR A  48
GLU A  41
THR A 138
LEU A 119
 None
 1.15A 5hm8F-3n0uA:
undetectable		 5hm8F-3n0uA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		4 / 5 THR A  48
GLU A  41
THR A 138
LEU A 119
 None
 1.15A 5hm8H-3n0uA:
undetectable		 5hm8H-3n0uA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		5 / 12 GLU A  35
LEU A  38
LEU A 107
ILE A 126
LEU A 119
 None
None
None
NA  A 208 (-4.9A)
None
 1.27A 5toaB-3n0uA:
undetectable		 5toaB-3n0uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 3n0u PROBABLE
N-GLYCOSYLASE/DNA
LYASE
(Thermotoga
maritima) 		4 / 5 THR A  48
GLU A  41
THR A 138
LEU A 119
 None
 1.03A 5utuH-3n0uA:
undetectable		 5utuH-3n0uA:
17.87