SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3n1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 3n1u HYDROLASE, HAD
SUPERFAMILY,
SUBFAMILY III A
(Legionella
pneumophila) 		5 / 12 LEU A 165
ALA A 169
ALA A 146
ILE A 116
ILE A  19
 None
 1.05A 1fk6A-3n1uA:
undetectable		 1fk6A-3n1uA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 3n1u HYDROLASE, HAD
SUPERFAMILY,
SUBFAMILY III A
(Legionella
pneumophila) 		5 / 11 LEU A 162
VAL A  29
CYH A  24
GLY A 117
LEU A 131
 None
 1.33A 1jkhA-3n1uA:
undetectable
1jkhB-3n1uA:
undetectable		 1jkhA-3n1uA:
17.32
1jkhB-3n1uA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 3n1u HYDROLASE, HAD
SUPERFAMILY,
SUBFAMILY III A
(Legionella
pneumophila) 		4 / 8 LEU A 162
ALA A  16
ILE A  19
GLY A 132
 None
 0.85A 1sv9A-3n1uA:
undetectable		 1sv9A-3n1uA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 3n1u HYDROLASE, HAD
SUPERFAMILY,
SUBFAMILY III A
(Legionella
pneumophila) 		5 / 11 LEU A  83
GLY A  84
ILE A  67
VAL A  26
LEU A  30
 None
 0.80A 2kawA-3n1uA:
undetectable		 2kawA-3n1uA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 3n1u HYDROLASE, HAD
SUPERFAMILY,
SUBFAMILY III A
(Legionella
pneumophila) 		5 / 11 LEU A  83
GLY A  84
ILE A  85
ILE A  67
LEU A  30
 None
 0.97A 2kawA-3n1uA:
undetectable		 2kawA-3n1uA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 3n1u HYDROLASE, HAD
SUPERFAMILY,
SUBFAMILY III A
(Legionella
pneumophila) 		5 / 11 ALA A 138
VAL A 139
GLY A  33
VAL A  29
GLY A 117
 None
 1.19A 4xnxA-3n1uA:
undetectable		 4xnxA-3n1uA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3n1u HYDROLASE, HAD
SUPERFAMILY,
SUBFAMILY III A
(Legionella
pneumophila) 		4 / 7 THR A 105
LEU A 106
LEU A 102
THR A  86
 None
 0.91A 4z90A-3n1uA:
undetectable
4z90B-3n1uA:
undetectable
4z90C-3n1uA:
undetectable
4z90D-3n1uA:
undetectable
4z90E-3n1uA:
undetectable		 4z90A-3n1uA:
18.46
4z90B-3n1uA:
18.46
4z90C-3n1uA:
18.46
4z90D-3n1uA:
18.46
4z90E-3n1uA:
18.46